[Modern laboratory technic--beginning of automated laboratory diagnosis].
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Automation↗
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Results for “Automation, Laboratory”
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Total laboratory automation can help eliminate the laboratory as a factor in emergency department length of stay.
We obtained data on laboratory turnaround time (TAT) and emergency department (ED) length of stay (LOS). We correlated potassium test TAT outlier percentage (TAT-OP) with ED LOS and found that for each outlier percentage (potassium result > 40 minutes), a projected impact on ED LOS was approximately 2.8 additional minutes (ED LOS = 2.79 TAT-OP + 78.77). To address this issue, we began implementation of a totally automated chemistry system to decrease TAT-OPs. Our TAT means did not change substantially with automation (potassium, 28 to 27 minutes); however, TAT-OPs decreased substantially (potassium, 18% to 5%). Preautomation average ED LOS correlated best with the TAT-OP (r(2) = 0.98; P = .01), but this relationship weakened substantially after automation (r(2) = 0.29; P > .05), suggesting the laboratory was no longer a factor in ED LOS. The postautomation ED LOS correlated best with ED patient volume (r(2) = 0.88; P = .06). Although laboratories have focused on TAT means for performance assessment, our study suggests TAT-OPs are more clinically relevant benchmarks. Furthermore, our findings suggest that total laboratory automation can effectively improve overall laboratory service reliability and help eliminate the laboratory as a factor in ED LOS.
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Recent trends in clinical laboratory automation.
A convergence of concepts has allowed clinical laboratory automation to proceed in a greater number of laboratories: developing automation control interfaces, direct track sampling, and adopting a universal interface. The laboratory automation system (LAS) must interface to the laboratory information system (LIS), which provides the information necessary for routing and scheduling and for future rules-based processing, an important component of the LAS. The automation system also must operate in a real-time or near real-time environment and use the single tube per carrier paradigm. LAS capabilities should span the clinical laboratory and run parallel to the LIS with respect to information flow. The laboratory automation software will control the automated technology and the transportation system that binds clinical laboratory instruments together. It must be able to both drive the hardware components and interface with patient information sources, and it should further the goals of the health-care delivery system by supporting outcomes optimization and utilization management of laboratory resources. The development of workcells based on disciplines such as chemistry or hematology is having and will continue to have a significant effect on the acceptance of clinical laboratory automation technologies.
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LABORATORY AUTOMATION HAS FREED THE TECHNOLOGIST.
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Total laboratory automation in Japan. Past, present, and the future.
The history of systematized automation in clinical laboratories in Japan started in 1981. At that time, about 12 laboratory technicians worked in a typical private University hospital laboratory (average size 1000 beds), whereas in national university hospitals (typical size 600 beds), the number of technicians was as low as 18-25. In 1981, the Kochi Medical School was founded as a new national school, and laboratory staffing was limited by the Ministry of Education to only 19 technicians for the first 3 years. Therefore, we started to develop a fully automated laboratory system by ourselves rather than accepting an intolerable shortage of technicians. The system was based on conveyor and robotic technology, and we called this approach systematization. Ten years later, systematized automation was introduced into the Japanese market. As a result, 72% of the national university hospitals in Japan installed commercial systems for systematization. There is a trend now in hospitals with sufficient numbers of technicians, to introduce fully automated systems in their laboratories as well, and even small hospitals with less than 100 beds are planning to introduce such systems. However, current technology is too expensive and not sufficiently standardized to meet the needs of these market segments in Japan. We recommend that companies agree on common shapes and sizes of racks and include more flexible robotic technology in their sample handling systems, to allow for plug and play systems and to make systematization affordable for every laboratory in the world.
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Intelligent software for laboratory automation.
The automation of laboratory techniques has greatly increased the number of experiments that can be carried out in the chemical and biological sciences. Until recently, this automation has focused primarily on improving hardware. Here we argue that future advances will concentrate on intelligent software to integrate physical experimentation and results analysis with hypothesis formulation and experiment planning. To illustrate our thesis, we describe the 'Robot Scientist' - the first physically implemented example of such a closed loop system. In the Robot Scientist, experimentation is performed by a laboratory robot, hypotheses concerning the results are generated by machine learning and experiments are allocated and selected by a combination of techniques derived from artificial intelligence research. The performance of the Robot Scientist has been evaluated by a rediscovery task based on yeast functional genomics. The Robot Scientist is proof that the integration of programmable laboratory hardware and intelligent software can be used to develop increasingly automated laboratories.
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[Laboratory automation for analysis of solid pharmaceuticals. Precision of automated analysis by a laboratory robot system].
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Chromatography, High Pressure Liquid↗
[Advances in the clinical laboratory automation system of Akita University Hospital].
Abstract Clinical laboratory automation, which was widely discussed in the 1960's, was developed in late he 1970's. The computerized automatic analyzing system for clinical laboratories spread nationwide in the 1980's. Akita University Hospital was established in 1971. We have been making efforts to establish the automated clinical laboratory system. The hematological and clinical chemistry divisions were automated in 1981. In 1988, in order to establish a fully automated clinical laboratory, we introduced sample-conveying systems in each division including hematological, clinical chemistry, urinalysis, serological and immunological divisions. In 1998, we connected the sample-conveying systems which had been separately established in each division to create a fully automated clinical laboratory with an integrated sample-conveying system.
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Laboratory automation and optimization: the role of architecture.
The increasing automation of laboratory equipment has had far-reaching impacts on the organizational structure and spatial requirements of clinical laboratories. This report explores the changing role of the laboratory in the healthcare environment and shows the architectural impact of these changes, both inside and outside of the laboratory space.
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[Laboratory automation and information technology in clinical microbiology--computerized support system and clinical competence of laboratory physician].
Laboratory automation and new information technology have considerable potential to improve care through protocols that reduce errors and guide diagnosis and therapy. Computer-based decision-support systems are now in place in many hospitals in the USA. For example, optimal decisions about the use of antibiotics in critically ill patients require access to a large amount of complex information, therefore a computerized decision-support program linked to computer-based patient records can assist physicians in the use of antiinfective agents and improve the quality of care. The support systems can educate physicians, guide their clinical reasoning, and measure the quality of the care that they provide. The installation of the computer components of the system is relatively easy, but the human components of the system may be much more difficult to transfer from hospital to hospital. The successful operation of the system should require a high level of clinical competence in every staff member of the hospital. The project should encompass a broad range of complex clinical conditions and decision algorithms. It must not be focused solely on the sophistication of laboratory methods. We, laboratory physicians/clinical pathologists must modify our behavior effectively and accept the value and limitations of laboratory automation and information technology. We must work more closely with physicians and other health care professionals as the best clients of our clinical laboratories and establish a good collaborative partnership with them.
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Three-year experience in using total laboratory automation system.
We implemented a total laboratory automation (TLA) system, currently used in Chungnam National University Hospital (CNUH), designed around the A&T Corporation to perform the general and specific laboratory testing throughout the system in a timely and cost-effective manner. The system consists of two major lines: chemistry and hematology. The analyzers attached to the hematology line include one SE 9000 hematology analyzer (Sysmex Corporation, Kobe, Japan), one SP-100 slide maker (Sysmex), and one R9000 reticulocyte counter (Sysmex). The chemistry line consists of preanalytic system and linked analyzers. The analyzers attached to chemistry line are one Hitachi 747 chemistry analyzer (Hitachi, Ltd., Tokyo, Japan), one A&T 502X analyzer (A&T Corporation, Tokyo, Japan) and one Architect i2000 immunochemistry analyzer (Abbott Diagnostics Division, Santa Clara, USA). The preanaytic system including start stocker, centrifuge, de-cap unit and aliquoting unit were connected with analyzers. The turn around time (TAT) of all tests was shortened in comparison to manual systems. Consequently it makes feasible one-day care clinic and makes reduced inherent errors in sample identification, dispensing, and reporting. In addition, real-time re-run can make test quality more reliable. As many as 12 departments can be reduced to 7 departments. The subsidiary advantages of smaller size were incorporated into reduced working steps facilitating workflow. Overall, better qualified and quicker results can be provided to the clinicians, and proper cost-effectiveness and better quality services can be anticipated as a result of much easier system management and higher reliability. In conclusion, the TLA has been successful within our laboratory.
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Laboratory automation: smart strategies and practical applications.
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Periodic health examinations using an automated multitest laboratory.
Automated multitest laboratories with automated, electronic, and computer equipment are used as an integral part of a routine periodic health examination for 4,000 patients a month. The automated multitest laboratory provides electrocardiography, anthropometry, chest and breast x-rays, visual acuity tests, tonometry, retinal photography, audiometry, vital capacity determinations, a health questionnaire on prepunched cards, and laboratory tests including eight blood chemistries done simultaneously with direct punched-card output. Before the patient leaves the multitest laboratory, additional indicated procedures are arranged in accordance with programmed computer "advice" rules. When all test reports are received, the computer prints out a summary report for the physician. The advent of automation and computers may introduce a new era of preventive medicine.
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Recent trends in laboratory automation in the pharmaceutical industry.
The impact of robotics and automation on the pharmaceutical industry over the last two decades has been significant. In the last ten years, the emphasis of laboratory automation has shifted from the support of manufactured products and quality control of laboratory applications, to research and development. This shift has been the direct result of an increased emphasis on the identification, development and eventual marketing of innovative new products. In this article, we will briefly identify and discuss some of the current trends in laboratory automation in the pharmaceutical industry as they apply to research and development, including screening, sample management, combinatorial chemistry, ADME/Tox and pharmacokinetics.
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Adapting the Biomek 2000 Laboratory Automation Workstation for printing DNA microarrays.
The Biomek 2000 Laboratory Automation Workstation is used for liquid handling and other repetitive operations in many laboratories. Since it has very good spatial positioning capabilities, we have modified this workstation to deliver samples at high densities onto microscope slides to produce DNA microarrays. The workstation tool, originally designed for bacterial colony replication, was adapted to carry special printing pins and was further modified to improve its positional accuracy. Software written in the Tool Command Language was concurrently developed to control the movements of the workstation arm during the process of printing. With these modifications, the workstation can reliably deliver individual samples at a spacing of 0.5 mm, corresponding to a total of more than 3000 samples on a single slide. Arrays prepared in this way were successfully tested in hybridization experiments.
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Recommendations of task force on laboratory automation.
The recommendations of the Task Force on Laboratory Automation are mainly general, applicable to all types of major equipment and covering in brief the points most likely to be overlooked in the purchase and installation of blood-grouping machines and allied units. The needs for collaboration between users and for the proper use of international standards are stressed. Specific recommendations on the two main systems cover financial implications and the use of the systems in screening for antibodies to red cell antigens.
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The implementation of a Multistat centrifugal analyzer in an automated laboratory.
The implementation of a centrifugal analyzer in an automated laboratory is discussed. Hardware and software requirements for the linkage between a MCA-III (Instrumentation Laboratories) and a desktop computer HP 9845B (Hewlett Packard) are described. A simple and reliable automated system working in a conversational mode was realized.
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