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PubMed1994

[Atrial fibrillation and the autonomic nervous system].

The autonomic nervous system plays an important role in the genesis of various cardiac rhythm disorders. Experimental studies have indicated that in atrial fibrillation particularly vagal activity may have a decisive influence on the electrophysiologic properties of atrial myocardium. In patients with paroxysmal atrial fibrillation, a carefully taken history and electrocardiographic findings obtained during Holter monitoring can help to distinguish vagally mediated from adrenergically mediated atrial fibrillation. The former is considered to represent a form of lone atrial fibrillation affecting particularly males aged 40 to 50 years. The arrhythmic episodes manifest themselves most often during the night lasting from minutes to hours. There is a lack of tendency towards the development of permanent atrial fibrillation. Digitalis glycosides or beta-receptor antagonists are not helpful in the therapy of this form of atrial fibrillation whereas class I antiarrhythmic drugs have been shown to be more effective. Adrenergically mediated atrial fibrillation is in general less frequently observed than the vagally-induced form. In patients with episodes of atrial fibrillation provoked by emotional or physical stress, the diagnosis of adrenergically mediated atrial fibrillation should be suspected. The episodes of atrial fibrillation occur mostly during daytime. beta-receptor antagonists play a major role in the treatment of this form of atrial fibrillation.

Adult↗
PubMedDate not supplied

Successful treatment of obstructive sleep apnea syndrome improves autonomic nervous system dysfunction.

Autonomic nervous system (ANS) dysfunction may be implicated in the subsequent development of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS). To confirm the relation between OSAS and ANS dysfunction, we prospectively investigated ANS function in 7 patients with moderate or severe OSAS; 7 healthy age-matched volunteers were for control. We also studied ANS function before and after treatment in the patients with OSAS to evaluate the effect of OSAS treatment on ANS dysfunction. The body mass index of patients with OSAS was 32.2 (27.4-45) (median [range]) kg/m2. The patients were treated by nasal continuous positive airway pressure (n = 5) or uvulopalatopharyngoplasty (n = 2). The apnea/hypopnea index decreased markedly from 42.1 (30.6-77.2) events/hr of sleep before treatment to 2.3 (1.4-3.8) after treatment. To evaluate ANS function, the coefficient of variation of the RR interval (CV-RR) and corrected QT (QTc) interval on the electrocardiogram at rest and the heart rate (HR) responses to blood pressure (BP) changes during the Valsalva maneuver were studied. Baseline HR of OSAS patients was significantly higher than that of the control subjects (p < .05). The Valsalva ratio (VR), baroreflex sensitivity (BRS), and CV-RR values in patients with OSAS were significantly lower than those of the control subjects (all, p < .005). However, there were no significant differences in systolic and diastolic BP or QTc intervals. After treatment, VR, BRS, and CV-RR values increased significantly compared with those before treatment in patients with OSAS (all, p < .05). There were no significant differences in systolic and diastolic BP, HR, or QTc intervals measured before and after treatment. These results suggest that impaired ANS function is present in patients with OSAS and can be improved by successful treatment of OSAS.

Adult↗
PubMed1977

Effects of varying inspiratory flow waveform and time in intermittent positive pressure ventilation. III: Blockade of the autonomic nervous system.

The autonomic nervous system was blocked in dogs which were exposed to independent alterations in inspiratory flow waveform and time whilst being ventilated artificially at a constant volume and frequency. There were statistically significant differences in cardiac output between the control and blocked states, but these differences were not of marked physiological significance. Alteration in inspiratory waveform or time in the blocked animals did not alter cardiac output significantly.

Animals↗
PubMed2006

Genetic variation in the renin-angiotensin system and autonomic nervous system function in young healthy Japanese subjects.

CONTEXT: The renin-angiotensin system (RAS) interacts with the autonomic nervous system (ANS) in the regulation of blood pressure and cardiovascular function. Several genetic polymorphisms in the RAS have been identified and have been implicated as a cause of hypertension and cardiovascular disease. OBJECTIVE: The aim of the present study was to evaluate the relation between genetic polymorphisms of the RAS (M235T of AGT gene, insertion/deletion of ACE gene, A1166C of AT1R gene, and A1675G of AT2R gene) and ANS function. SUBJECTS: One hundred forty-nine young healthy Japanese males were genotyped for each RAS polymorphism. MAIN OUTCOME MEASURES: ANS function was evaluated by power spectral analysis of heart rate variability (HRV) during supine rest and in a standing position. RESULTS: In a supine position, subjects homozygous for the AGT 235T allele had a higher HRV sympathetic index than 235M allele carriers, whereas the orthostatic change in this index was relatively blunted in AGT 235TT carriers. In the analysis of gene-gene interaction, these effects of the AGT 235T homozygotes on HRV sympathetic index were more apparent in the presence of the ACE D allele. Meanwhile, the AT1R 1166C allele was significantly associated with higher HRV low-frequency power and sympathetic index in a standing position. These data suggest that the AGT M235T polymorphism is associated with sympathetic predominance at rest, and AT1R 1166C allele carriers have potentially increased sympathetic response. CONCLUSIONS: Cardiac autonomic function can be modulated by genetic variation in the RAS even in young and healthy states.

Adolescent↗
PubMedDate not supplied

[Physiology of the autonomic nervous system].

INTRODUCTION: The autonomic nervous system (ANS) is made up of a complex set of neurons and pathways that control the functioning of the different body systems within the organism. Its overall function is that of maintaining a state of homeostasis in the organism and of performing the adaptation responses when faced with changes in the external and internal environment. METHODS: The ANS is composed of visceral afferent pathways, integration centres at the brain stem, hypothalamus and cerebral cortex levels, as well as sympathetic and parasympathetic efferent pathways. The efferent pathways innerve the cardiac muscle, the smooth muscle and the exocrine and endocrine glands, while the afferent pathways are arranged in two patterns: oligosynaptic circuits, which mediate reflex adaptation responses of the visceral systems, and complex circuits, with projections to nuclei in the brain stem and the brain, where the information is collected and responses are produced that affect numerous systems. The afferent signals activate or inhibit the efferent components of the ANS by means of reflex pathways, independently of the will. These reflex circuits are also modulated by means of signals from central structures, and constitute a central autonomic neuronal network that integrates somatic, autonomic and affective responses. CONCLUSION: Dysfunctions of the ANS are possibly due to increases or decreases in autonomic control activity, which can appear because of lesions to the brain, spinal cord or peripheral nerves.

Autonomic Denervation↗
PubMedDate not supplied

Directional preponderance of nystagmus and excitement of autonomic nervous system.

Since autonomic nervous dysfunction is the most common predetermining factor of vertigo, the functional relationship between these two systems was studied using the rabbits. Cervical sympathectomy or electric stimulation of the superior cervical ganglion were given to the animal on one hand, and modulation of the blood pressure and electric stimulation of the hypothalamus were done, on the other. These manoeuvres rarely induced asymmetry of the vestibulo-ocular reflex (VOR). However, when other pairs of conditions were combined, such as cervical ganglion stimulation and BP modulation, or sympathectomy and hypothalamic stimulation, directional preponderance of VOR became prominent. This experimental model seems to explain the mechanism of vertigo observed.

Animals↗
PubMed1997

AAEM minimonograph #48: autonomic nervous system testing.

The autonomic nervous system maintains internal homeostasis by regulating cardiovascular, thermoregulatory, gastrointestinal, genitourinary, exocrine, and pupillary function. Testing and quantifying autonomic nervous system function is an important but difficult area of clinical neurophysiology. Tests of parasympathetic cardiovagal regulation include heart rate analysis during standing (the 30:15 ratio), heart rate variation with deep breathing, and the Valsalva ratio. Tests of sympathetic adrenergic vascular regulation include blood pressure analysis while standing, the Valsalva maneuver, sustained handgrip, mental stress, and cold water immersion. Tests of sympathetic cholinergic sudomotor function include the sympathetic skin response, quantitative sudomotor axon reflex test, sweat box testing, and quantification of sweat imprints. Pupil function is tested pharmacologically and with pupiilographic techniques. Tests of gastrointestinal and genitourinary function do not satisfactorily isolate autonomic regulation from their other functions. The available tests have various sensitivities and ease of administration. They are typically administered in a battery of multiple tests, which improves sensitivity and reliability, and allows probing of various autonomic functions.

Autonomic Nervous System↗
PubMed1990

[A study of erythromelalgia in relation to the autonomic nervous system. Report of 321 cases of functional disorders of the autonomic nervous system].

A great majority of erythromelalgia were seen among 321 cases of disorders of the autonomic nervous system. When the function of the autonomic nervous system was disturbed, the acromelic blood vessels under the regulation by the autonomic nervous system manifested themselves in the manner of acroerythema, hot sensation, local swelling and distension, and severe acroesthesia.

Adolescent↗
PubMedDate not supplied

[Effects of inorganic lead exposure on the autonomic nervous system and on the variability of heart rate among workers at a battery plant].

Inorganic Lead can cause a toxic effect on Central Nervous System, Peripheral Nervous System and Autonomic Nervous System (ANS). A damage of the ANS can determine an heart rate variability (HRV) reduction. In this study 43 battery workers exposed to inorganic lead with mean PbB = 31.63 microg/dl (DS 14.77 microg/dl) and 35 not exposed subjects underwent to an evaluation of heart rate variability by specific tests. Heart rate variability in the exposed group was, for some tests (lying to standing, lying to standing-standing to lying) reduced compared with not exposed subjects and for other tests (Valsalva manouvre, lying to standing-standing to lying) correlated with PbB and Zinc Protoporphyrin (ZPP), but not with BMI, age and smoking habits. This study, like others conducted on similar populations, suggest an effect of occupational inorganic lead exposure on Autonomic Nervous System and heart rate variability

Adult↗
PubMed2002

[Selected methods for evaluating the autonomic nervous system].

Dysfunction of autonomic nervous system, accompanying different diseases of central and peripheral nervous system, is manifested by cardiovascular, gastrointestinal, genitourinary, thermoregulatory, respiratory and pupillary disorders. In the paper the methods of autonomic nervous system evaluation are reviewed, in particular the most popular cardiovascular and thermoregulatory tests.

Autonomic Nervous System Diseases↗
PubMedDate not supplied

[A correlation between food allergy, the autonomic nervous system and the central nervous system: a study of 8 patients in childhood].

The aim of our study was demonstrate the correlation between immunoallergic system, autonomous nervous system (SNA) and central nervous system (SNC). Eight children allergic to food and with asthma, damage of handwriting, deambulation and behaviour were deprived of food allergens. The RAW (indicator of SNA activation) diminished and the respiratory flow increased. The neurologic symptomatology improved. The reintroduction of food allergens induced reappearance of asthmatic and neurologic symptomatology.

Adolescent↗