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Results for “Awareness”

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PubMed1992

Public awareness of home accident risks--some implications for health promotion.

Through daily contact with injured people there was a feeling that most people are sufficiently aware of the dangers in specific risk factor activities, but were not fully aware that they could do a lot to prevent harm coming upon themselves. This paper describes the results of a self-administered questionnaire about the accidents people suffered at home, their level of awareness of the risk they were undertaking, whether they had had a similar accident before, what they think the recovery period from their injury is likely to be and knowledge of, and accidents involving, 17 generally known risk activities. The results confirm that most people are indeed aware of dangers yet a large number still have accidents in spite of that. The results also indicate that campaigns advising people how to avoid these dangers could be successful.

Accident Prevention↗

PubMed1975

The awareness of risk and personal relevance in alcoholics.

From the perspective of health professionals, the estimated nine million alcoholics in America are engaged in repetitive health-avoidance behavior. The purpose of this study was to asses whether alcoholics were themselves aware of the risk-taking implications of their drinking, particularly in view of the denial clinically attributed to alcoholics. Horn's Smoker's Self-Testing Kit, modified to measure respondents' attitudes toward excessive drinking and its consequences, was administered to 61 alcoholic inpatients. This instrument evaluates awareness of the health hazards of excessive drinking, awareness of the seriousness of alcoholism as a health problem, awareness of its personal relevance, and the value of stopping, concern with mastery of the drinking problem, and belief in capability for stopping. The results indicated that during sobriety these alcoholics definitely acknowledged the health hazards of excessive drinking, the seriousness of the problem, its personal relevance, and the value of stopping. However, subjects generally anticipated great difficulty in making any significant change in their self-destructive drinking patterns.

Alcohol Drinking↗

PubMed1977

Effects of instructional set and self-awareness on task performance of retarded female adults.

The effects of success, failure, and neutral instructional sets on the task performance of retarded female adults were studied under varying conditions of self-awareness. A significant Set X Self-Awareness interaction was found where subjects in the neutral-set condition under high-awareness assembled more pens than subjects under the medium- or low-awareness conditions. The results were discussed in light of the expectancy of failure hypothesis.

Achievement↗

PubMed2026

A leakage-aware genomic prediction pipeline for meropenem resistance in Klebsiella pneumoniae using transformer-based resistome representation learning.

MOTIVATION: Antimicrobial resistance (AMR) in Klebsiella pneumoniae, particularly to carbapenems such as meropenem, is a major global health problem. Machine learning is increasingly used to predict resistance from genomic markers; however, many models fail to capture high-level gene-gene interactions and may exhibit inflated performance due to lineage-biased prediction. Existing genomic prediction models largely rely on flat feature representations that fail to capture epistatic gene interactions, and commonly suffer from inflated performance estimates due to phylogenetic data leakage. To address these limitations simultaneously, a leakage-aware hybrid TabTransformer-CatBoost pipeline was developed, combining self-attention-based resistome representation learning with gradient boosting classification under clade-aware data partitioning. A self-attention encoder converts sparse gene presence-absence profiles into contextualized latent embeddings, which are subsequently classified using gradient boosting to capture lineage-aware AMR patterns. RESULTS: The proposed architecture outperformed classical baselines including Logistic Regression, Random Forest, XGBoost, and optimized CatBoost models. Internal accuracy reached 92.59% for the Chained Hybrid configuration (area under the receiver operating characteristic curve, AUROC = 0.8670, F1 = 0.8537). Performance gains primarily originated from the embedding stage, as confirmed by ablation analysis. External validation across independent multinational cohorts (n = 305) demonstrated generalizability (AUROC = 0.8105; F1 = 0.7552). Permutation testing produced near-zero Matthews Correlation Coefficient (MCC) = 0.0091, indicating predictions reflect genuine biological signal rather than noise. These results establish attention-based genomic embedding with gradient boosting as a scalable, interpretable, and leakage-aware framework for clinical AMR prediction. AVAILABILITY AND IMPLEMENTATION: The source code for the TabTransformer-CatBoost framework, including preprocessing pipelines and pre-trained embeddings, is available at https://github.com/SibelKervanci/kp-meropenem-tabtransformer.

Journal Article↗

PubMed1976

Awareness during electromyographic biofeedback: of signal or process?

During relaxation training, awareness of trial-to-trial changes in frontalis-muscle tension levels was assessed with and without auditory electromyographic (EMG) biofeedback. Immediately after each 128-sec training trial, the subject was required to guess whether muscle tension indexed by EMG activity increased ("Up") or decreased ("Down") relative to the immediately preceding trial. The probability of correct guessing, P(c), improved as the absolute difference in EMG increased between trials only when biofeedback was presented. For subjects not receiving biofeedback, P(c) remained low even when the absolute difference between trials was large. Subjects in each condition employed a strategy to guess "Down" more often consistent with the expectation that they were being trained to relax. The "Down" set strategy was shown to be separable from the informational basis of P(c) provided by biofeedback. This procedure can be employed to evaluate central assumptions of biofeedback relating to posttraining awareness of changes in muscle tension and the relationship between awareness and control of muscle tension.

Acoustic Stimulation↗

PubMed1979

Awareness, muscle relaxants and balanced anaesthesia.

The incidence of awareness during insufficient anaesthesia is reported to be one per cent. It is usually due to the use of muscle relaxants, a balanced technique and the lightest possible depth of anaesthesia. Increased incidences were noted in open-heart surgery, during intubation-endoscopy procedures and in caesarean delivery patients. Experiences of awareness are disturbing to patients, who are usually benefited by a sympathetic and forthright explanation of the event. Fourteen representative cases of the problem are reported. Since no adequate sign or test exists for detection of awareness during very light anaesthesia or with associated paralysis, more meticulous attention is required in using relaxants or the balanced technique. Greater anaesthetic supplementation and reduction in the use of relaxants are recommended to halt the recurrence of this most serious anaesthetic problem.

Adult↗

PubMed1979

Autonomic classical conditioning as a function of awareness of stimulus contingencies.

Two groups of 32 college students were presented compound CSs (lights and tones presented simultaneously) during a classical conditioning paradigm. By means of a masking task and verbal instructions, a partially informed group was made aware of only the visual CS's contingency with the UCS, while a fully informed group was made aware of both the visual and auditory contingencies. Autonomic indices of conditioning (electrodermal responses, heart rate, and digital pulse volume) were later measured to the individual component CSs and to various compound CSs. It was found that: (1) the partially informed group exhibited conditioning exclusively to the visual CS+ and to compounds which included the visual CS+, while (2) the fully informed group exhibited conditioning to both visual and auditory CS+s. The results confirm the importance of awareness in human autonomic discrimination classical conditioning. It is suggested that human autonomic conditioning may be usefully conceptualized as an information processing task with the autonomic indices of conditioning reflecting central cognitive processes.

Acoustic Stimulation↗

PubMed1992

Young children's awareness, knowledge, and beliefs about AIDS: observations from a pretest.

Starting from the assumption that AIDS education can be most effective when initiated prior to the age when AIDS risk behaviors emerge, a number of researchers and public health officials have advocated AIDS education for preadolescents. Yet there have been few published reports assessing children's awareness, knowledge, and attitudes about AIDS and persons with AIDS. In this paper, basic data are presented for each of these dimensions broken down by race, gender, and grade. The data suggest that, although many students are aware of AIDS by the first grade, it is not until the fifth grade that nearly all students are aware of the existence of the disease. Over all, nearly 44% of the students who know about the disease believe that they or someone they know will get it. Students in the fifth grade have a higher level of AIDS knowledge than those in the first grade, but even the former are relatively uniformed and have a number of misconceptions about the disease and persons with it. Children's attitudes reflect confusion and some anxiety over AIDS and the treatment of persons with it. Some significant race and gender differentials are noted.

Acquired Immunodeficiency Syndrome↗

PubMed1978

Increased clinic awareness and attitudes of independence through client advisory board membership.

In order to determine the effect of client advisory board membership on clients' awareness of a clinic, and on client attitudes of independence, the responses of 13 board members were compared with those of 13 matched controls on two self-report measures (Clinic Recognition Test, Client Independence Questionnaire) before and after 3-month periods. Analysis of the results indicated that, whereas the responses of controls did not significantly change on the Client Independence Questionnaire, the responses of board members indicated a significant increase in attitudes of independence. And, even though both board members and control clients significantly increased their awareness of clinic and staff over 3 months, the awareness of the broad members was significantly greater than that of the control clients.

Adult↗

PubMed2026

SeqQC-former: A sequence-quality fusion framework for QC-aware review prioritization of candidate somatic SNVs in cancer genomics.

The accurate prioritization of candidate somatic single-nucleotide variants (SNVs) remains a challenge due to the substantial variability in sequencing quality across genomic loci. SeqQC-Former is a sequence-quality fusion framework that integrates the local nucleotide context with read-level quality-control (QC) covariates derived from matched tumor-normal sequencing data. This integration generates QC-aware prioritization scores for the downstream review of candidate variants. Unlike conventional variant callers, SeqQC-Former is designed not to infer biological truth but to support post-calling review and prioritization under heterogeneous sequencing conditions. The framework was trained and evaluated on a SEQC2-derived dataset comprising 89,447 candidate loci, including 1378 positive and 88,069 negative loci. In chromosome-held-out validation, which aims to reduce potential genomic-position leakage, SeqQC-Former demonstrated strong discrimination (AUROC = 0.9479; AUPRC = 0.9448), indicating good generalization to previously unseen chromosomes. Given that the SEQC2-derived labels contain QC-associated information; these results should be interpreted as an evaluation of QC-aware prioritization capability rather than an independent validation of biological variant correctness. Ablation analyses revealed that structured QC covariates provided the dominant predictive signal under the current SEQC2-derived labeling regime. SeqQC-Former achieved a significantly higher AUROC than classical machine-learning baselines, as determined by DeLong's test (p < 0.01). Application to 53,164 glioblastoma variants demonstrated that external predictions were sensitive to QC scaling and threshold selection, underscoring that model outputs should be interpreted as QC-dependent prioritization scores rather than calibrated probabilities or definitive biological classifications. Overall, SeqQC-Former offers a reproducible post-calling QC-aware prioritization framework for large-scale somatic SNV review and underscores the importance of explicitly modeling sequencing-quality information when interpreting structured cancer genomics datasets.

Humans↗

PubMed1976

Bladder cancer in rubber workers. Do screening and doctors' awareness distort the statistics?

The use of recognised carcinogens in the rubber industry before 1950 led to the introduction of screening progammes offering urinary cytology to workers who had been exposed. Publicity given to the introduction of these programmes and to individual claims for compensation have increased medical practitioners' awareness of a relationship between work and the industry and the subsequent development of bladder cancer. In this study 27 rubber workers and 88 controls registered in 1966 and 1967 with bladder cancer have been followed. A comparison of their death-rates and of the relative frequency of bladder cancer recorded on the death certificates should indicate whether cytological screening or doctors' awareness might explain a recent rise in the bladder-cancer death-rate in this industry. Since the proportions of rubber workers and controls who died before 1976 were similar (74% and 73% respectively) and bladder cancer was mentioned with similar frequence on their death certificates (80% and 83% respectively) neither screening nor doctor's awareness would appear to have an important influence.

Adenocarcinoma↗

PubMed2026

A modular class-aware workflow for small RNA sequencing analysis using mouse sperm as a case study.

BACKGROUND: Small RNA sequencing analysis is challenging because RNA classes differ in biogenesis, sequence redundancy, genomic organization, and annotation reliability. Integrated workflows accommodating these constraints remain limited, particularly for fragment-level and cluster-level analysis. METHODS: We present a reproducible, containerized, class-aware workflow for small RNA sequencing analysis, using mouse sperm as a case study. The workflow combines standardized preprocessing with complementary annotation and quantification strategies for microRNAs (miRNAs), transfer RNA-derived small RNAs (tsRNAs), ribosomal RNA-derived small RNAs (rsRNAs), and PIWI-interacting RNA (piRNA)-enriched genomic clusters. Using sperm small RNA data from offspring of lipopolysaccharide (LPS)-exposed male mice, we compared integrated-reference mapping, multi-class annotation, fragment-level tsRNA profiling, and genome-based piRNA cluster analysis, with custom modules for locus-aware harmonization and condition-specific cluster analysis. RESULTS: Integrated-reference mapping aligned 88.17% of reads and retained 690 features after filtering. It identified 11 differentially expressed miRNAs between LPS and controls, while other classes showed limited signal. Fragment-level profiling improved tsRNA resolution. piRNA cluster analysis identified 958 control and 940 LPS clusters, with 18 control-specific and no LPS-specific clusters. CONCLUSION: This workflow supports transparent, reproducible, class-aware interpretation of small RNA sequencing data while emphasizing cautious interpretation of piRNA-enriched signals from total small RNA sequencing.

Small non-coding RNA analysis↗

PubMed1978

Prevalence and awareness of malocclusion in Swedish men.

Previous orthodontic treatment, the awareness of malocclusion, the demand for orthodontic treatment and the prevalence of malocclusion were studied in 389 Swedish men, aged 21-54 years (mean age 32 years). Nine percent had been treated with an orthodontic appliance and 15% reported that permanent teeth had been extracted on orthodontic indications. Malposition of teeth was found in 75%, with rotation as the most common type of malposition. Crowding was recorded in 43% and spacing in 18%. Fifty-seven percent had some occlusal anomaly. The need for orthodontic treatment was rated on a four-point scale. It was found that 76% were in need of treatment. The need for treatment was only slight in half of the men but moderate to urgent in 25% of the sample. About a quarter of the men were aware of malposition of front teeth, equally often for maxillary and mandibular teeth, but only about 1% were aware of malposition of posterior teeth. Only a few percent thought they were in need of orthodontic treatment. The presence of malocclusion was correlated to age, place of birth and educational level. This might perhaps be a consequence of tooth loss.

Adult↗

PubMed2026

Aligning awareness, systems and policy to increase equitable access to genomically driven cancer care.

Genomic testing has the potential to transform cancer care across the patient pathway. However, its benefits remain unevenly realised across populations and health systems. Precision oncology is characterised by a strong promissory discourse, with expectations of improved outcomes and cost-effectiveness, yet real-world implementation remains variable and context dependent. This review examines how patient and public awareness interacts with, and is constrained by, structural, organisational and political-economic factors that shape equitable access to genomically driven cancer care across five themes: (1) the power of patient and public advocacy; (2) learning from the patient perspective; (3) culturally responsive communication; (4) structural and personal barriers and facilitators and (5) political economy of health. Examples are mapped across global regions to highlight how health system, structural and societal factors continue to limit the universal realisation of genomic medicine's benefits. We present four recommendations to strengthen the translation of awareness into equitable access and clinical impact: (1) expand and adequately power genomic studies in underserved populations; (2) improve risk communication and decision-making across the cancer pathway; (3) equitable validation and interpretation of emerging genomic technologies and (4) generate real-world evidence on access, uptake and outcomes of genome-matched therapies. Embedding awareness, trust, access and equity in future initiatives is imperative to realise the promise of precision medicine for all patients.

Biomarkers↗

PubMed2026

MetaServe: a lightweight, metadata-aware governance and delivery layer for pre-publication research omics data.

BACKGROUND: Institutional research teams and core facilities routinely manage pre-publication omics datasets that span heterogeneous file types, nested project structures, and multiple downstream uses. Public repositories mainly support post-publication dissemination, while workflow systems and enterprise data platforms do not directly provide a lightweight governance and delivery layer for internal research assets. RESULTS: We present MetaServe, an open-source governance and delivery layer for pre-publication research assets in institutional multi-omics settings. MetaServe registers and delivers heterogeneous assets, including sequencing files, processed matrices, imaging data, analysis-ready objects, tabular files, and documents, without requiring repository-grade standardization. Its metadata-aware design combines file-type recognition, partial automatic extraction for selected formats, manually supplied project and biological annotations, and indexed faceted retrieval. MetaServe supports authenticated web download, viewer-oriented handoff for compatible services such as cellxgene, and path-manifest export for downstream workflows under shared-storage assumptions. The current implementation combines role-based controls, explicit file-level sharing, path-constrained delivery, and operational traceability to support controlled institutional access. MetaServe has been deployed at the Chinese Institutes for Medical Research (CIMR) as part of an institutional multi-omics data-management system. CONCLUSIONS: MetaServe provides a practical layer between institutional storage and downstream analytical platforms for pre-publication research data. Its contribution is the integration of lightweight metadata-aware registration, permission-aware retrieval, and controlled delivery for heterogeneous institutional omics assets. Rather than replacing workflow engines, public repositories, or enterprise-scale research data platforms, MetaServe offers a deployable governance layer for core facilities and collaborative teams that need structured discovery and traceable delivery before public deposition or manuscript release.

Metadata↗

PubMed1992

Reproductive knowledge, and contraceptive awareness and practice among secondary school pupils in Bagamoyo and Dar-es-Salaam, Tanzania.

Reproductive knowledge, and contraceptive awareness and practice were assessed among secondary school pupils in Bagamoyo and Dar-es-Salaam, Tanzania. Four classes from four government secondary schools were randomly selected within strata of year of schooling, and students were interviewed using a structured questionnaire. All 490 pupils in selected classes participated in the study. Of 481 respondents with complete data, 315 (65.5 pc) were males and 166 (34.5 pc) were females; 256 (53.2 pc) were from Dar-es-Salaam while 225 (46.8 pc) were from Bagamoyo. Two hundred and ninety three (60.9 pc) respondents reported they were sexually active. However, only 77 (17.0 pc) pupils knew the "safe period" within the menstrual cycle and 329 (68.4 pc) pupils were able to spontaneously mention at least one method of contraception. Less contraceptive awareness was noted among respondents below 18 years of age particularly among females in both study areas. Only 45 (15.4 pc) pupils had ever used a contraceptive method. Despite a reasonable level of awareness and a positive attitude towards contraception, only a small proportion of sexually active pupils had ever used contraceptives. More research is required to identify the barriers to contraceptive use in the presence of knowledge.

Adolescent↗

PubMed1992

Public awareness and acceptance of dental implants.

To investigate public awareness and acceptance of dental implants, 120 adult US citizens were asked to answer a questionnaire. Of the 109 persons who completed the questionnaire, 77% had heard about dental implants, mostly through media and lay persons. Only 17% named a dentist or physician as the source of information. Persons with many missing teeth were not more aware of implants than those with fewer missing teeth. Of 19 removable denture prosthesis wearers, 15 knew about implants but only one third learned of them from their dentist or physician. Of 84 persons with information about implants, 51 would consider implant treatment, 17 would not, and 16 were undecided. Esthetics was the most frequent motivating factor favoring implants, while high cost was the most frequent argument against them. Younger interviewees were significantly more often in favor of implants than older persons. It was concluded that public awareness and acceptance of dental implants are high. Dentists and physicians, however, play only a minor role as sources of information.

Adult↗

PubMed1975

The stimulation of insight and self-awareness through body-movement exercise.

The results suggest that even a brief body-movement experience can enhance understanding and self-awareness among normal students in a classroom setting. It may be that exercises could be used in other areas of learning or exploration. These completely noverbal activities may have the same beneficial effects as role-playing, with respect to increasing insight and self-awareness.

Adolescent↗