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PubMed1961

The inheritance of the glucose component of the phage nucleic acids.

The wild type strains of T2 and T6 bacteriophages differ in their host range specificity, efficiency of plating on E. coli K12, and in glucose content. A study of the inheritance of these three differentiating characteristics has revealed that they are transmitted both upon serial passage of the viruses and when the two phages are crossed. It has been found, furthermore, that an extensive recombination takes place upon crossing. Four types of hybrid phages have been isolated from the progeny of crosses, which had a glucose content of one of the parental phages, and either the host range specificity or efficiency of plating or both of the other. The characteristics of each hybrid were found to be hereditarily stable. It has been concluded that the transmission of the characteristics under consideration is determined genetically and that the genes which control them are not closely linked. Since the glucose content of a phage is determined by the degree of glucosylation of its nucleic acid, the T2 and T6 phages apparently contain genes which control certain chemical properties of their nucleic acid.

Bacteriophages↗
PubMed1962

Bacteriophage genes and bacterial functions.

This brief survey of bacteriophage infection has provided support for an obvious but important generalization: that the study of virus infection at the cellular level is a branch of cellular genetics. The interactions between viral and cellular functions show that infection with a virus is not just a disrupting intrusion; it is an addition to the cellular endowment of genetic specificity. The outcome of this addition depends on the nature of the instructions carried by the viral genome, on the ability of the cellular machinery to carry out these instructions, and on the availability of control mechanisms to regulate the functions of the added element.

Bacterial Physiological Phenomena↗