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Biosoluble surgical material from 2,3-dialdehyde cellulose.

Dialdehyde cellulose (DAC) was prepared by periodate oxidation of various cellulosic materials in the form of sutures and bandages. The suitability of using DAC for making bioabsorbable sutures and antimicrobial wound dressing bandages was studied. The investigations indicated that DAC combines the requisite mechanical strength with an inherent antimicrobial nature. It was found that the oxidation of cellulose to yield DAC also rendered it bioabsorbable. The DAC was coated with different concentrations of urea formaldehyde in order to improve the mechanical properties for making sutures.

Aldehydes↗

Comparison of removable rigid dressings and elastic bandages in preprosthetic management of patients with below-knee amputations.

The purpose of this study was to determine if the removable rigid dressing is more effective in preprosthetic management than the conventional support dressing with elastic bandages. Residual limb circumference, independent application of the dressing, tendency of the dressing to remain secure, development of pressure areas, and presence of pain were evaluated in two groups of below-knee amputees. Subjects were randomly assigned to use either removable rigid dressings or conventional elastic bandages. Residual limb circumference was measured three times a week, and the other variables were measured weekly. The results indicated that the removable rigid dressing is more effective in preprosthetic management than the elastic bandage.

Aged↗

An audit of peripheral catheter care in a teaching hospital.

Post-insertion care of peripheral venous catheters (PVCs) in 100 patients on general medical and surgical wards of a teaching hospital was audited. A variety of methods were used to attach the PVC to the patients' skin including 'Vecafix' dressings, bandages and adhesive tape. Sixty-eight PVC were incorrectly attached, and of these 49 (71%) were associated with two or more symptoms or signs of inflammation at the insertion site. Of those PVC that were correctly attached only five out of 32 (16%) were associated with inflammation. There was a significant association between incorrect dressing application and inflammation (P < 0 center dot 01). Similarly, there was a direct relationship between inflammation and PVCs that had been in situ for greater than 48 h (P < 0 center dot 01). The results suggest that a significant reduction in the incidence of inflammation associated with PVC use may be achieved by correct application of dressings and replacing the catheters after 48 h in situ.

Bandages↗

Perceived health in a randomised trial of treatment for chronic venous ulceration.

STUDY OBJECTIVE: To observe changes in perceived health in patients during a clinical trial of treatments for venous leg ulceration. DESIGN: Randomised prospective factorial trial in patients with venous ulceration. Each patient randomised to a bandage, dressing and a drug. Perceived health assessed at entry and after 24 weeks. SETTING: Outpatient departments and patient's home. PATIENTS: Two hundred patients presenting to two vascular services in Falkirk and Edinburgh with chronic (duration > 2 months) non-healing venous ulceration. STATISTICAL ANALYSIS AND MAIN RESULTS: Analysis using the Nottingham Health Profile revealed that after 24 weeks there were significant improvements in all subscores (p < 0.01) with the exception of social isolation (p = 0.081). Patients with healed ulceration had improved in energy, pain, emotion, sleep and mobility compared with those whose ulceration failed to heal (p < 0.05). Patients randomised to four layer bandaging had significantly better energy (diff = 7.9, 95% CI 0.2, 15.6, p = 0.04) and mobility (diff = 4.5, 95% CI 0.0, 9.0, p = 0.046). This difference could be explained largely by the improved healing of patients randomised to this bandage system (67/97 vs. 50/103, OR = 2.37, 95% CI 1.31, 4.27). CONCLUSIONS: Improvements in perceived health were significantly greater in patients whose ulcers had completely healed. Methods of treatment which offer improved healing for patients with venous leg ulceration are likely to improve patients' perceived health status.

Adult↗

Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration.

BACKGROUND: Chronic wounds, including pressure sores, leg ulcers, diabetic foot ulcers and other kinds of wounds, healing by secondary intention are common in both acute and community settings. The prevention and treatment of chronic wounds includes many strategies, including the use of various wound dressings, bandages, antimicrobial agents, footwear, physical therapies and educational strategies. This review is one of a series of reviews, and focuses on the prevention and treatment of diabetic foot ulcers and the role of antimicrobial agents in chronic wounds in general. OBJECTIVES: To assess the clinical- and cost-effectiveness of (1) prevention and treatment strategies for diabetic foot ulcers and (2) systemic and topical antimicrobial agents in the prevention and healing of chronic wounds. METHODS - DATA SOURCES: Nineteen electronic databases were searched, including MEDLINE, CINAHL, Embase and the Cochrane Library. Relevant journals, conference proceedings and bibliographies of retrieved papers were hand-searched. An expert panel was consulted. METHODS - STUDY SELECTION: Randomised and non-randomised trials with a concurrent control group, which evaluated any intervention for the prevention or treatment of diabetic foot ulcers, or systemic or topical antimicrobials for chronic wounds (diabetic foot ulcers, pressure ulcers, leg ulcers of various aetiologies, pilonidal sinuses, non-healing surgical wounds, and cavity wounds) and used objective measures of outcome such as: (1) development or resolution of callus; (2) incidence of ulceration (for diabetic foot ulcer prevention studies); (3) incidence of pressure sores (pressure sore prevention studies); (4) any objective measure of wound healing (frequency of complete healing, change in wound size, time to healing, rate of healing); (5) ulcer recurrence rates; (6) side-effects; (7) amputation rates (diabetic foot ulcer treatment studies); (8) healing rates and recurrence of disease, among others, for pilonidal sinuses. Studies reporting solely microbiological outcomes were excluded. Decisions on the inclusion of primary studies were made independently by two reviewers. Disagreements were resolved through discussion. Data were extracted by one reviewer into structured summary tables. Data extraction was checked independently by a second reviewer and discrepancies resolved by discussion. All included studies were assessed against a comprehensive checklist for methodological quality. INCLUDED STUDIES - DIABETIC FOOT ULCERS: Thirty-nine trials which evaluated various prevention and treatment modalities for diabetic foot ulcers: footwear (2), hosiery (1), education (5), screening and foot protection programme (1); podiatry (1) for the prevention of diabetic foot ulcers; and footwear (1), skin replacement (2), hyperbaric oxygen (2), ketanserin (3), prostaglandins (3), growth factors (5), dressings and topical applications (9), debridement (2) and antibiotics (2) for the treatment of diabetic foot ulcers. INCLUDED STUDIES - ANTIMICROBIALS: Thirty studies were included, 25 with a randomised design. There were nine evaluations of systemic antimicrobials and 21 of topical agents. QUALITY OF STUDIES: The methodological and reporting quality was generally poor. Commonly encountered problems of reporting included lack of clarity about randomisation and outcome measurement procedures, and lack of baseline descriptive data. Common methodological weaknesses included: lack of blinded outcome assessment and lack of adjustment for baseline differences in important variables such as wound size; large loss to follow-up; and no intention-to-treat analysis. RESULTS - PREVENTION OF DIABETIC FOOT ULCERS: There is some evidence (1 large trial) that a screening and foot protection programme reduces the rate of major amputations. The evidence for special footwear (2 small trials) and educational programmes (5 trials) is equivocal. A single trial of podiatric care reported a significantly greater reduction in callus in patients receiving podiatric care. RESULTS - TREATMENT OF DIABETIC FOOT ULCERS: Total contact casting healed significantly more ulcers than did standard treatment in one study. There is evidence from 5 trials of topical growth factors to suggest that these, particularly platelet-derived growth factor, may increase the healing rate of diabetic foot ulcers. Although these studies were of relatively good quality, the sample sizes were far too small to make any definitive conclusions, and growth factors should be compared with current standard treatments in large, multicentre studies. Topical ketanserin increased ulcer healing rate in 2 studies, while systemic hyperbaric oxygen therapy reduced the rate of major amputations in 1 study. Preliminary research into the effects of iloprost and prostaglandin E1 (PGE1) on diabetic foot ulcer healing suggests possible benefits. However, good quality, large-scale confirmatory research is needed. (ABSTRACT TRUNCATED)

Administration, Topical↗

Laser cartilage reshaping in an in vivo rabbit model using a 1.54 microm Er:Glass laser.

BACKGROUND AND OBJECTIVES: The potential applications for facial laser cartilage reshaping (LCR) have generated increasing clinical interest. This study aimed to evaluate in vivo LCR of the rabbit ear using a 1.54 micro m Er:Glass laser in combination with contact cooling. STUDY DESIGN/MATERIALS AND METHODS: LCR was performed in vivo on 12 rabbit ears using a 1.54 micro m Er:Glass laser (Aramis, Quantel Medical, Clermont Ferrand, France) connected to a 4 mm chilled (+5 degrees C) handpiece placed in contact to the skin. Ear curvature was predetermined using a perforated cylindrical guide also used to standardize laser beam delivery. The treatment consisted of 15 spots (3 millisecond, 7 pulses, 12 J/cm(2), 2 Hz, 84/cm(2) cumulative fluence) applied on 10 contiguous parallel rows along the ear. After irradiation, the aluminum jig was replaced by a holder (10 mm diameter plastic tube) maintaining the curvature. This holder was secured with sutures and covered by an adhesive gauze bandage dressing to keep new form during 7 days. In order to assess thermal damage, biopsies were taken on irradiated areas and 1 week, 3 weeks and 6 weeks and studied using haematoxylin-erythrosin-safran (HES) and orcein staining and PCNA to detect cells in cycle. RESULTS: Using the laser with the parameters given above, no immediate visible effects were observed on the skin (no swelling, no bleaching). There were also no late visible side effects like crusting, or blistering. The laser treatment produced changes in the shape of every ear after the dressing was removed. A slight tendency to recover its initial shape was observed for each ear. However, the curvature was stabilized after 10 days and the average shape retention was 64+/-4% at 6 weeks, with a curvature radius of 7.25+/-0.75 mm, instead of 5 mm initially. Histological examination of the laser irradiated side at 1 week showed an intact epidermis. A reduced inflammation process was seen in the dermis. A modification of half of the layer of cartilage was observed at the opposite side where the laser irradiation was applied and proliferative cells were detected inside. At 3 weeks, an important chondroblastic proliferation was observed around the area of contracted cartilage. At 6 weeks, significant thickening of the cartilage layer was observed (from 300 to 490 micro m) and new chondrocytes were clearly seen. CONCLUSIONS: Rabbit ear cartilage can be reshaped with an Er:Glass laser. This technique could offer exciting possibilities that may help patients whose cartilage-lined joints have been affected by disease or trauma. This technique could be certainly utilized to correct alar cartilage deformities and septum deviation of cleft lips.

Animals↗

Realtime telemedicine for teaching a first-aid course.

We evaluated a realtime, distance-learning first-aid course at three schools. From September 1997 to January 1998, 180 students took the course (60 at each of three sites, one of which was the broadcast site). Self-administered questionnaires were distributed to students at the end of the course. The overall response rate was 86%. Sixty-three per cent of students at the remote sites and 83% of students at the broadcast site rated the programme as good or excellent. Students at the broadcast site had a significantly higher degree of satisfaction with the video (79% vs 30%) and audio (83% vs 44%) quality than those at the remote sites. Students at the broadcast site also had a significantly higher degree of satisfaction with slides (75% vs 43%) and transparencies (60% vs 44%) as teaching tools than those at remote sites. The three most important factors affecting the course at the remote sites were teaching aids (video, slides, transparencies), the teacher's body language and self-expression, and equipment stability. Satisfaction at the broadcast site was significantly lower when the course involved demonstrations or practice procedures such as cardiopulmonary resuscitation, dressing, bandaging or splinting. Teaching aids and equipment therefore appear to be important factors at remote sites for a first-aid telemedicine course. Limitations in teachers' movements during demonstration and practice were important at the broadcast site. The evaluation and selection of appropriate teaching models, teaching tools and methods are important when implementing these types of educational programme.

Adolescent↗

Using different designs in wound healing research.

Wounds are common, expensive to treat and prevent patients from returning to their normal activities. Wound healing as a clinical specialty has only developed over the past 20 years, and this is an area of practice where there is a very strong impetus towards ensuring that, as far as possible, all health care is evidence based. Scientific wound healing research has a long history, but clinical research in this field is much more recent. Clinical wound healing research has particular challenges related to the nature of the patients and the interventions being studied. Wounds are a symptom, rather than a disease, and patients often present with multiple or complex pathology. Wound healing interventions typically include dressings, bandages and mattresses, all of which are highly visible to researchers and patients alike. This makes the design and execution of experimental studies challenging. For example, the 'blinding' of researchers, patients and staff to highly visible interventions is very difficult. In this article, Sue Bale discusses the use of four different designs that have been employed: case studies, non-comparative studies, quasi-experimental studies, and randomised controlled trials. The value and contribution of each is explored.

Evidence-Based Medicine↗

[Nursing practice in home care: social-demographic profile and professional practice].

OBJECTIVES: To characterise the Andalusian nurses providing home care (HC), to describe the activities developed, to define the components of nursing practice and to identify differences between the care of terminal cancer, of AIDS patients, of elderly people with dementia and of patients who had undergone more serious out-patient surgery. DESIGN: Cross-sectional descriptive study using a postal questionnaire. SETTING: Primary care centres in Andalusia. PARTICIPANTS: 348 PC nurses working in home care. Multi-stage sampling, proportional by provinces. MAIN MEASUREMENTS: Social-demographic and work characteristics, nursing activity in the home, type and frequency of activities performed in the care of each kind of patient and use of protocols. RESULTS: 61.14% reply rate. 65.5% were women, with mean age of 39.7 and averaging 10 years of PC experience. Mean number of patients attended was 10.5 per week, and mean time was 20.7 minutes. 90.1% had attended cancer patients, 16.7% AIDS patients, 83.3% elderly people with dementia, and 87.2% patients discharged early. In all cases the most commonly developed item was the technical one, followed by preventive/health promotion and psycho-social. Except in the case of evaluation of physiological needs, in all the other activities the frequency of the item was in function of the pathology of the patient (P<.05). Nursing practice in the home of terminal cancer patients and of elderly people with dementia only differs in the handling of emotional problems in both patient and carer, and in the preventive item (P<.05). 60% of the sample said they used no protocol in home care. CONCLUSIONS: The most common activities in care of home care patients are giving treatment, dressings, bandages, and monitoring of the vital constants, followed by assessment of physiological needs. Nursing practice does not seem to be fully conditioned by the pathology, but rather in function of groups of patients with similar needs and problems. Most Andalusian home-care nurses use no protocol in caring for these four classes of patient.

Acquired Immunodeficiency Syndrome↗

The use of an implantable central venous (Hickman) catheter for long-term venous access in dogs undergoing bone marrow transplantation.

Methods were developed for the insertion and maintenance of long-term central venous catheters in dogs in order to provide reliable venous access during bone marrow transplantation. Single-lumen, 9.6 Fr Hickman catheters with a VitaCuff were used. The catheter was inserted into the jugular vein via a surgical cut-down, and tunnelled subcutaneously to exit over the thoracic spine. Fluoroscopic guidance was necessary to ensure proper positioning of the catheter tip in the right atrium. The catheter was secured at the venous entrance site with a grommet and at the cutaneous exit site with a finger-cuff suture. The exit site was bandaged; dressings were changed daily. Five dogs were studied. Catheter insertion and maintenance techniques were developed using two dogs. For the other three dogs, which developed 7 wk of profound myelosuppression induced by total body irradiation, the catheters were used for blood sampling and infusions of antibiotics, fluids, and blood products. For these three dogs there were 261 total catheter-days. Complete catheter obstruction did not occur. Partial obstruction (inability to withdraw blood) occurred for 13 days with one catheter. The tip of this catheter was in the cranial vena cava. One irradiated dog had a staphylococcal exit site infection for several days after catheter insertion, which resolved with antibiotic therapy. Infections of the subcutaneous tunnel, and catheter associated bacteremia, were not identified. Infectious and hemorrhagic complications of myelosuppression were less severe than in six other dogs where intermittent venipuncture was used for vascular access during radiation induced myelosuppression. In conclusion, long-term central venous catheterization is feasible in dogs during profound myelosuppression and markedly facilitates patient management.

Animals↗

[Heel pressure ulcers. Comparative study between heel protective bandage and hydrocellular dressing with special form for the heel].

INTRODUCTION: The heels, together with the sacra area, are one of the most frequent spots where pressure sores appear here in Spain. Any preventive measure against pressure sores on heels needs be oriented towards two main objectives: effective relief of pressure and its compatibility with localized care and skin inspection in order to detect lesions early on at least once a day. PATIENTS, MATERIALS AND METHODS: The authors planned a comparative, multi-centered, open, labeled and controlled study in which patients were assigned to two groups receiving these treatments: one received traditional preventive pressure sore treatment and a protective bandage on their heels while the other used a special Allevyn Heel hydrocellular dressing to protect their heels. The patients took part in this study over an eight week period. The response variable used to determine the effectiveness of the preventive measure in this study was the appearance of pressure sores. RESULTS: At the beginning, 130 patients were included in this study, 65 in each one of the treatment groups. In the bandage group, 50 patients finished this study while 61 in the dressing group finished this study. The appearance of pressure sores in the protective bandage group occurred in 44% of the patients, 22 out of 50, while in the dressing group, the occurrence rate was 3.3%, 2 out of 61 patients with a value of "ji" squared p < 0.001. The risk factor to develop a pressure sore brought us a value of relative risk of 13.42 (IC 95%: 3.31-54.3) in the group wearing the protective bandage compared to the group wearing the dressing. COMMENTS: The results of this study allow us to accept as valid the alternate hypothesis that there exist significant statistical differences between both treatment methods in favor of the Allevyn Heel dressing instead of the protective heel bandage. The use of this dressing, even though it is more expensive a priori than the protective bandage, in terms of unit cost for the product, has proven to be more effective in preventing pressure sores, and cheaper than the protective bandage if we bear in mind these combination of variables: time of usage, application and removal.

Bandages↗

Octyl-2-cyanoacrylate liquid bandage as a wound dressing in facial excisional surgery: results of an uncontrolled pilot study.

BACKGROUND: Although cyanoacrylate tissue adhesives are frequently used in the closure of cutaneous lacerations and excisions, only a few reports comment on their usefulness as a dressing over sutured wounds. A new formulation of octyl-2-cyanoacrylate (Liquid Bandage; BAND-AID, Johnson & Johnson) is used as an occlusive protective film over minor cuts and scrapes. OBJECTIVE: An uncontrolled pilot study to assess the safety, efficacy, and cost of Liquid Bandage as an occlusive dressing over sutured facial excisions. METHODS: Patients undergoing excision of facial neoplasms were recruited. After conventional layered repair, Liquid Bandage was applied. On suture removal, the wounds were photographed and evaluated by three dermatologists, who assigned an overall outcome rating. The average cost of Liquid Bandage and routine wound care materials was calculated based on prices from three different pharmacies. RESULTS: Of the 18 wounds available at follow-up, 17 were assigned an overall outcome rating of good or excellent by at least one of the evaluators. Eleven wounds received an excellent rating from at least two of the evaluators. One case of distal flap necrosis occurred. Liquid Bandage proved to be less expensive than routine postsurgical wound care materials. CONCLUSIONS: Liquid Bandage dressing is safe and effective over sutured facial excisions.

Adolescent↗

Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing.

BACKGROUND: Venous leg ulcers are a common cause of morbidity, but few predictive parameters exist that can be used to follow their progress. OBJECTIVE: We investigated the use of healing rate as a useful parameter in the treatment of venous ulceration. METHODS: Twenty-seven venous ulcers being treated with a standard regimen were evaluated. We calculated the initial (4-week) and overall healing rates using the Gilman method (delta A/p). RESULTS: The average initial healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.069, 0.087, and -0.005 cm/wk, respectively. Similarly, the average overall healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.062, 0.089, and -0.043 cm/wk, respectively. CONCLUSION: The initial healing rate (delta A/p(0-4)) may be an appropriate end point for clinical investigations comparing therapies for the treatment of chronic venous leg ulcers.

Bandages↗