Protection of human subjects: Institutional Review Board; report and recommendations of National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.
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The importance of ethological analysis of primates behaviour during the medicobiologic research has been shown. The concrete examples of methods of differentiation and registration of behavioral patterns in the models of psychoemotional stress in primates are given. The systemic approach to the study of behaviour allows to determine the behavioral data of the individual state--the composition of functional spheres, the number of elements, the frequency of their appearance, the system of domination-subjection characteristics of the sequences of behavioral acts and to find out their dynamics in different stages of experiment. The comparison of these data with physiologicobiochemical data is necessary to obtain the integral picture of individual reaction to the experimental factors.
Regulations recently enacted by the Public Health Service and the National Science Foundation to address misconduct in scientific research were designed primarily to curtail deliberate forms of misconduct, such as fabrication or falsification of findings; however, researchers may also be held accountable for inadvertent deficiencies in data management. This article examines some of the problems in data quality control, documentation, and data retention that can occur when computers are used in scientific research. It focuses on deficiencies that could make it difficult to verify the integrity of research data or to reproduce statistical analyses. Strategies for prevention of data management problems are recommended.
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