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PubMed2025

Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes.

Histones play a fundamental role in eukaryotic organisms not only as scaffolding proteins in DNA packaging but also in regulating gene expression. They constitute the protein reel around which DNA wraps forming nucleosomes. This initial packing gives rise to the chromatin fiber which is next folded into three-dimensional arrangements. Additionally, histones have expanded their functions through the emergence of histone variants which have specialized purposes and can deeply affect chromatin organization and dynamics. Moreover, both canonical histones and histone variants comprise the building blocks of the histone code by being targets of different post-translational modifications (PTMs) that occur in a highly regulated manner both in place and time. Most of the above-mentioned about chromatin organization is conserved among eukaryotes. However, trypanosomatid histones have many peculiarities that entail a special description. In this review, we compile the current knowledge of canonical core histones, histone variants, and their PTMs in trypanosomatids. We highlight the similarities and differences between histone variants and their canonical counterparts in trypanosomatids, and we compare them with those from model organisms. Finally, we discuss the crosstalk between different histone marks and their genomic distribution underlying the uniqueness of trypanosomatids.

Histones↗
PubMed1993

Childhood cancer in relation to a modified residential wire code.

Several studies have found associations between wire configuration codes, a proxy for historical residential magnetic field exposure, and childhood cancer. The Wertheimer-Leeper coding method was modified by eliminating the distinction between thick and thin primaries, distinguishing only between open and spun secondaries, and reducing the number of categories from five to three. The association between the modified code and measured magnetic fields was similar to the association with the original wire code. The modified code was used to reanalyze data from a case-control study of childhood cancer in the Denver metropolitan area. In the original study, cases were diagnosed from 1976 to 1983 among children under age 15 and compared to controls selected through random digit dialing. Wire codes for the residence at diagnosis yielded imprecise elevations of two and above for very high current configuration homes or modest 1.5-fold elevations for a dichotomous wire code. In contrast, the modified Wertheimer-Leeper code generated risk estimates that were both precise and markedly elevated for the high wire code (HWC) compared to low wire code (LWC) classifications, with medium wire code (MWC) showing little or no increase in risk. High wire code yielded odds ratios of 1.9 for total cancers (95% CI: 1.1-3.2), 2.9 for leukemias (95% CI: 1.5-5.5), and 2.5 for brain cancer (95% CI: 1.1-5.5) that were not confounded by measured potential risk factors for childhood cancer. These risk estimates are larger than the dichotomized results and more precise than those from the original five-level wire code, though limitations in the original study remain, particularly potential control selection bias.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

Use of wiring configuration and wiring codes for estimating externally generated electric and magnetic fields.

The relative locations and characteristics of the distribution lines feeding 434 residences in the Denver metropolitan area were recorded and classified according to the Wertheimer-Leeper code (WL code) as a part of an epidemiological study of the incidence of childhood cancer. The WL code was found to place the mean values of the fields in rank order. However, the standard deviations were approximately the same size as the means. Theoretical calculations indicate that a significant fraction of the low-power magnetic fields can be generated by the distribution lines, especially in the cases where the distribution lines are within 50 feet of the residence. Thus, the wiring code was shown to be a useful method for making a first-order approximation to predict long-term, low-level magnetic fields in residences.

Building Codes↗
PubMed1993

Protection against radon-222 at home and at work. A report of a task group of the International Commission on Radiological Protection.

The Commission has used an epidemiological basis for the assessment and control of radon exposure in this report. Since all the available epidemiological studies use the quantity inhaled potential alpha energy, this has been used as the primary quantity in this report. The Commission does not recommend the use of the dosimetric human respiratory model (ICRP, 1994) for the assessment and control of radon exposures. The Commission sees practical advantages in the delineation of radon-prone areas where more buildings than usual have elevated radon levels. For dwellings, it is suggested that areas with more than 1% of buildings with radon concentrations exceeding ten times the national average concentration might be designated as radon-prone, but the choice will depend on local conditions. A similar approach might be adopted in non-residential areas. Action against radon should be focused on such radon-prone areas. The imperatives of intervention against adventitious exposure to radon in buildings are clear. Above appropriate action levels, intervention is practicable and usually more cost-effective than other investments in radiological protection. Two types of building need to be considered, dwellings and workplaces. In both cases, radon concentrations are most likely to be elevated by the ingress of soil gas from the subjacent ground. Preventive and remedial measures to avoid this circumstance are recommended. The action levels adopted should fall within the recommended range of values given in Table 7. Proven measures against radon are readily available. For remedial work, the technical procedure that is most likely to maintain the radon level to a value well below the action level should be adopted from the outset. Intervention should take place soon after the discovery of elevated levels, especially if the concentrations are substantially above the action levels adopted by the competent authority. For preventive work, construction codes and building guides should be devised that will consistently achieve low concentrations of radon in the completed buildings. In workplaces, both in buildings and underground, where the radon concentrations remain above the recommended action level after any appropriate remedial measures have been taken, the Commission's system of protection should be applied and radon should be treated in the same way as any other radioactive material at work. The relevant data on conversion coefficients are given in Table 6 and the main quantitative recommendations are summarised in Table 7. Corresponding values in historical units are given in Table 8.

Air Pollution, Indoor↗
PubMed1986

Respiratory disease in a photographer.

Reversible airways obstruction occurred in a photographer after long-term exposure (over many years) to sulfuric and acetic acid fixers. Air-exchange recommendations for darkrooms by the Building Officials Code Administration [1981] differ markedly from those recommended by the American Society of Heating, Refrigerating, and Airconditioning Engineers [1977] and the fixer manufacturer (Eastman Kodak). Use of fume hoods or rates of air-exchange higher than are required by law may be necessary to prevent symptoms and disease in certain workers.

Adult↗
PubMed1990

Shielding requirements on-site loading and acceptance testing on the Leksell gamma knife.

On August 14, 1987, the first stereotactic radiosurgical procedure using the gamma knife was performed in North America. Located in a self-contained radiosurgical suite in the basement of Presbyterian-University Hospital in Pittsburgh, Pennsylvania. This device uses 201 highly focused beams 60Co for the single-treatment closed-skull irradiation of brain lesions localized by stereotactic techniques (radiosurgery). One hundred and fifty-two patients with intracranial arteriovenous malformations or brain tumors were treated in the first year of operation. The Presbyterian University Hospital of Pittsburgh gamma knife is the first such unit in which the 60Co sources were loaded on-site. This effort required us to solve some difficult and unusual problems encountered during site preparation, delivery, and loading of the unit in a busy hospital setting. The solutions developed enabled installation and use of the gamma knife with minimal disruption of hospital activities while maintaining acceptable levels of exposure to radiation. Environmental surveys performed during the loading of the 201 radioactive sources (total, 219 TBq) confirmed that on-site loading is possible and practical. Our experience in the design, construction, and implementation of the first North American gamma knife supports the practicality and safety of on-site loading and may be of value in the planning and development of future gamma knife installations.

Brain Neoplasms↗
PubMed1991

Regulation of in-place asbestos-containing material.

Approximately two-thirds of New York City's 800,000 buildings contain asbestos. Most of this material is damaged or deteriorating. Legislation pending in the New York City Council (Bill number 453) would require virtually all building owners to inspect for asbestos, to develop management and maintenance plans to prevent disturbance of intact material, and to provide notice of the presence of asbestos to building occupants. This paper reviews the legislation and discusses its features that have been questioned. It concludes that regulation of in-place asbestos is necessary and appropriate.

Animals↗
PubMed1984

Shielding hospital rooms for brachytherapy patients: design, regulatory and cost/benefit factors.

The current regulations of the U.S. Nuclear Regulatory Commission (NRC) normally require limitation of radiation exposure in any part of unrestricted occupied areas to 2 mrem in any one hour and to 100 mrem in 7 days. To meet these limits when patients are treated therapeutically with radioactive materials, it is advisable to designate specific rooms in a hospital and often necessary to incorporate substantial costly shielding into one or more walls and the room door. Plans have been formulated for shielding existing hospital rooms housing brachytherapy patients receiving 192Ir and 137Cs therapy in order to meet the above NRC requirements for adjacent corridors and rooms. Typical shielding thicknesses required are 4-6 in. of concrete for certain walls and 1/4 in. of lead in the doors. Shielding costs are approx. $6000 per room for one shielded wall and a shielded door. Applying recent estimates of the cancer risk from low-level gamma radiation, the cost of shielding per cancer fatality averted has been estimated to range from $1.8 million to $10.9 million. Cost/benefit comparisons with many other life-saving activities suggest that these costs and the application of the 2 mrem/hr limit which necessitated them are not justified.

Brachytherapy↗