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At least 37 records · Page 2Linked to original sources
PubMed1961

Tissue amine levels and sympathetic blockade after guanethidine and bretylium.

A single dose of guanethidine produces a substantial, long-lasting depletion of tissue catecholamines in the rat, whereas a similar dose of bretylium has no effect. Both drugs produce block of the eserine-induced sympathetic pressor effect. Block by guanethidine is induced more rapidly than is amine depletion. When amine depletion is maximal, a noradrenaline infusion is capable of restoring the response to eserine, but no restoration of the response to eserine occurs after noradrenaline infusion into bretylium-treated rats. Catecholamine levels in isolated tissues are not reduced when complete block of sympathetic nerve stimulation has been produced by guanethidine. It is suggested that guanethidine possesses a primary bretylium-like, and a secondary reserpine-like, blocking action. Guanethidine produces a transient lowering of intestinal 5-hydroxytryptamine, and this coincides with increased intestinal motility.

Amidines↗
PubMed1962

Effect of adrenaline infusions on the catechol amine content of cat and rat tissues.

Infusions of adrenaline failed to produce a significant increase in the adrenaline and noradrenaline content of cat uterus and kidney and of rat uterus and spleen, using normal and reserpine-treated animals. The adrenaline content of extracts of the organs was assayed on the isolated rat uterus, which was stimulated electrically; the noradrenaline content was assayed on the blood pressure of the pithed rat. The tissues studied contained relatively small quantities of adrenaline and this was not decreased by reserpine. Our results show a difference between the stores of adrenaline and noradrenaline in these tissues; the noradrenaline stores are larger, they are depleted by reserpine, and they are increased by an infusion of noradrenaline.

Animals↗