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At least 37 records · Page 2Linked to original sources
PubMed2002

Expression of integrins and MMPs during alkaline-burn-induced corneal angiogenesis.

PURPOSE: To determine in a corneal alkaline burn model of angiogenesis whether the expression of integrins and MMPs is consistent with a VEGF-induced angiogenic response. METHODS: Neovascularization in female Sprague-Dawley rats was induced by alkaline cauterization of the central cornea. RT-PCR for integrins alpha(1), alpha(2), beta(3), and beta(5); the endothelial marker CD31; and metalloproteinases MMP-2 and MT1-MMP was performed on naive corneas and on cauterized corneas 72 and 288 hours after cautery. Analyses of protein and MMP expression were conducted on naive corneas and on cauterized corneas 24, 72, 120, and 168 hours after cautery by immunofluorescence microscopy and gelatin zymography. RESULTS: RT-PCR indicated a correlation between the induced angiogenic response and the expression of alpha(1) and beta(3) integrin subunits and MT1-MMP. Immunohistochemical analysis indicated that alpha(1), alpha(2), alpha(5), and beta(5) integrins and MMP-2 and MT1-MMP were expressed on the newly developing vasculature. The beta(3) integrin was preferentially expressed on platelets. CONCLUSIONS: Integrin expression during neovascularization of rat corneas in response to alkaline injury correlates with an angiogenic response that uses the VEGF/alpha(v)beta(5) pathway. MMP-2 and MT1-MMP, but not MMP-9, are expressed in a pattern consistent with their involvement in the angiogenic response.

Alkalies↗
PubMed1981

Autoradiographic study of corneal neovascularization induced by chemical cautery.

The corneas of adult rats were cauterized chemically, and the responses of the pericorneal blood vessels and the cellular constituents of the cornea were followed by light microscopic autoradiography after labeling with 3H-thymidine. As in previous experiments, this injury elicited a neovascularization as capillaries sprouted and extended centripetally from the corneoscleral limbus to the cautery site. Chemical cautery induced a response in the epithelium, endothelium, and fibroblasts of the cornea as well as in the vascular cells. Elevated labeling indices for the corneal epithelium and endothelium began at 18 and 21 hours after injury, respectively. In all of these corneal cell types, the labeling index returned to control values by 75 hours. The onset and decline of DNA synthesis in corneal fibroblasts paralleled that of the corneal epithelium and endothelium. Labeling indices of vascular cells (endothelial cells and pericytes) increased 21 hours after injury, reached a maximal level at 45 hours, and returned to control values by 1 month after cautery. The first mitoses in vascular endothelial cells and pericytes were noted 36 hours after injury, and the initial capillary sprouts appeared at 39 hours. This study demonstrates that the thymidine incorporation by cells in the pericorneal blood vessels occurs early within the postcauterization period, at least 15 hours before the first mitotic figures are detected in these same vascular cells. The significance of the temporally related elevations in labeling indices of the vascular cells and the cellular constituents of the corneal cells is uncertain, but there are many potential interrelationships between the controls of cell division and migration for cells of the vessels, epithelium, endothelium, and corneal stroma.

Animals↗
PubMed1987

Phenol cauterization of nail matrix remnants.

Incomplete destruction of the nail matrix may result in partial recurrence of the nail. This occurs most frequently at the lateral ends of the proximal nail fold. A procedure that provides permanent, satisfactory results consists of careful dissection of the recurrent nail fragments followed by local phenol cauterization.

Cautery↗
PubMed1988

The effect of scleral cautery on corneal astigmatism in cadaver eyes.

We studied the effect of scleral cautery on corneal astigmatism in 20 cadaver eyes using the Zeiss wetfield bipolar cautery either at or 2 mm posterior to the corneoscleral limbus. The chord of cauterized area was set at either 5.5 or 11 mm. Cautery induced net corneal steepening along the meridian of the cauterized area, and induced the greatest astigmatism when applied at the limbus. At each location the 11-mm cautery application induced less astigmatism. The majority of the astigmatic change occurred within the first 5 to 10 seconds of application. We found that scleral cautery at or 2 mm posterior to the limbus can induce extensive corneal astigmatism.

Astigmatism↗
PubMed1999

Utility of MIB-1 in evaluating cauterized cervical cone biopsy margins.

Interpretation of cervical cone biopsy margins removed by loop electrosurgical excision procedure is often problematic as a result of cautery artifacts. In this study, MIB-1 expression in cauterized tissues was almost identical to that in the adjacent noncauterized epithelium (correlation coefficients 0.97-0.98). Cauterized dysplastic/condylomatous epithelium showed significantly greater expression of MIB-1 than cauterized normal epithelium (p < or = 0.004) at all levels of the epithelium. Cut-off points for distinguishing dysplastic/condylomatous epithelium from normal epithelium were >15%, 30%, 5%, and 1% of cells in the basal, basal one-third, middle one-third, and surface one-third of epithelium, respectively.

Antigens, Nuclear↗