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Results for “CEREBRAL ARTERIOSCLEROSIS”

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At least 37 records · Page 2Linked to original sources
PubMed1982

Effect of cardiac glycosides on the release of adenylate kinase into cerebrospinal fluid of patients with cerebral arteriosclerosis.

48 patients with cerebral arteriosclerosis were found to have a manifest release of adenylate kinase (AK) into cerebrospinal fluid (CSF). This release was most probably due to an increased leak in the brain cells subsequent to a lowered adenylate charge potential followed by a diminished electrochemical potential in these cells suffering from disturbed oxygen supply. A further increase of AK release into CSF was noted for the 22 patients receiving cardiac glycosides compared to the 26 patients not treated with these drugs. The mean AK value of the former group was 0.119 +/- 0.028 U/l compared to that of the latter group, being 0.089 +/- 0.025 U/l, and this difference was significant (p less than 0.001). The effect of cardiac glycosides is most probably explained by an additional lowering of the membrane electrochemical potential in brain cells of these patients due to the direct action of cardiac glycosides on the Na+- and K+-dependent ATPase system in these cells, resulting in an increased leak in the plasma membrane.

Adenylate Kinase↗
PubMed2005

[Observation of the cognition and the velocities of blood in the brain in cerebral arteriosclerosis and infarct patients].

OBJECTIVE: To observe the change of the cognition and the supply of blood in brain in healthy people and patients with arteriosclerosis (AS) and cerebral infarct. METHOD: 1) control group: healthy people, 30 cases. 2) AS group: 22 cases with cerebral arteriosclerosis. Cerebrovascular infarct patients were divided into two groups. 3) 2W group: 21 cases, the patients' course of disease was shorter than two weeks. 4) 6M group: 20 cases, the patients' course of disease was from six months to four years. All cases were checked with cognitive P300 and transcranial doppler ultrasound (TCD) and mini-mental status examination (MMSE). RESULT: The result revealed that the P300 incubation period in 2W group, 6M group and the AS group was remarkable extend than the control group (P<0.01), meanwhile the period of the 6M group was longer than the AS group (P<0.05); the amplitude of the wave of the 2W group and 6M group were shorter than the control group (P<0.05; 0.05). The velocities of bilateral MCA and right ACA were remarkable improved in AS group (P<0.05; 0.01), and the velocities of left MCA both in 2W and 6M group, the right ACA and BA in 6M group were remarkably decreased than the control group (P<0.05; 0.01). The grades of MMSE in all patients were lower than the control group and the grades in 6M group was lower than the AS group. CONCLUSION: There are some changes in the P300 and abnormality of brain blood supply in the cerebral infarct patients and AS patients. The longer the course, the more serious of the cognition with the patients.

Adult↗
PubMedDate not supplied

[Cerebral arteriosclerosis: neurologic and psychiatric consequences].

Cerebral arteriosclerosis is a frequent, often not sufficiently diagnosed disease in the second half of the life span. Possible causes, diagnosis, and therapy are explicitly shown of its somatic and psycho-pathological symptoms, often acute, and chronically persistent. Particular emphasis is put on acute-care and the therapeutic relevance of socio-and psychotherapy. Finally, consequences for forensic medical opinions are shown.

Aged↗