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Results for “Cellulose, Oxidized”

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PubMed2001

Noncovalent immobilization of bovine serum albumin on oxidized cellulose.

Immobilization of bovine serum albumin (BSA) on oxidized cellulose (OC) containing carboxylic groups, a biocompatible and bioresorbable polymer, was investigated in water and different buffer solutions (pH 2-7) at 5 degrees C. The maximum amounts of BSA loaded on OC in pH 2, 3, 4, 6, and 7 buffer media were 9.82, 10.52, 8.86, 9.16, 6.05, and 2.69% (w/w), respectively. In water, the corresponding value was 9.82%. The release study was performed on powder, pellet and suspension (in castor and sesame oils) dosage forms of OC-BSA immobilization products prepared in water and pH 2 buffer, in pH 7.4 phosphate buffer at 37 degrees C. The results revealed the release of BSA to be the fastest from oil suspensions, intermediate from powders, and slowest from pellets. In conclusion, the results presented suggest that OC has the potential to be used as an immobilizing matrix for BSA and other proteins in water and pH 2-4 buffer solutions.

Cellulose, Oxidized↗
PubMed1986

Oxidized cellulose for preventing adnexal adhesions.

Oxidized cellulose gauze (Surgicel) was evaluated for its ability to prevent postsurgical pelvic adhesions. Ten New Zealand white female rabbits were subjected to laparotomy and standardized bilateral trauma to the fimbria and ovaries. On one side in each rabbit the ovary and uterine tube were wrapped in Surgicel. The untreated side in each rabbit served as the control. Four weeks later the rabbits' pelvises were reexplored, and the adhesions on both sides were scored. The overall adhesion scores on the treated sides (mean +/- SD = 4.24 +/- 1.28) were significantly higher than those on the control sides (mean +/- SD = 1.5 +/- 1.06, P less than .001). Surgicel appeared to enhance, rather than prevent, adhesion formation in the rabbits.

Adnexal Diseases↗
PubMed2003

Hemostyptic effect of oxidized cellulose on blood platelets.

Cellulose is one of the hemostyptic biomaterials, which are able to initiate or accelerate blood coagulation at the site of their application. It belongs to surgical sealants. The mechanism of its action is not clearly understood. We studied the participation of blood platelets in this mechanism. As a marker of platelet activation we used serotonin release reaction. Serotonin release in platelet rich plasma incubated with various concentrations of oxidized cellulose (0.5%-2.0%) started in about 20 min. Washed platelets were not directly activated by oxidized cellulose within one hour. Washed platelets reconstituted in plasma obtained from two patients with coagulation factor XII deficiency were activated by oxidized cellulose with a prolonged lag phase. Our results demonstrate the significant influence of factor XII on blood platelets activation by oxidized cellulose.

Blood Coagulation↗
PubMed2004

[Oxidized cellulose (Surgicel) mimics an abscess after laparoscopic partial nephrectomy].

INTRODUCTION: Oxidized cellulose gauze (Surgicel) left into the surgical bed can mimic a gas-forming abscess in the close postoperative image studies, because of air trapped within the interstices of the gauze, before that being degraded. PATIENT AND METHOD: In the early postoperative CT scan of a laparoscopic partial nephrectomy due to renal cell carcinoma, two small collections of gas were found, at the sites where Surgicel was placed. Being aware of the surgical details, they were not confused with an abscess. COMMENT: Small collections of gas into a Surgicel gauze may be detected until more than a month after surgery, imitating a bacterial abscess, but the clinical context, operative reports and a good communication between the surgeon and the radiologist should avoid this mistake.

Abscess↗
PubMed1993

Appearance of oxidized cellulose (Surgicel) on postoperative CT scans: similarity to postoperative abscess.

OBJECTIVE: Oxidized regenerated cellulose (Surgicel), a sterile knitted fabric that causes thrombus formation because of its physical properties, is frequently used for intraoperative hemostasis. Unlike traditional surgical sponges, it is bioabsorbable and can be left in the surgical bed. On CT scans, the appearance of the retained oxidized cellulose can mimic that of an abscess. The purpose of this study was to describe the appearance of oxidized regenerated cellulose on postoperative CT scans so that an erroneous diagnosis of an abscess can be avoided. MATERIALS AND METHODS: We reviewed the CT examinations of five postoperative patients in whom oxidized regenerated cellulose had been used for surgical hemostasis. Operative reports and surgeons confirmed the use of oxidized cellulose. Four CT scans were abdominal examinations, and one was a head examination. RESULTS: In four cases, CT scans showed focal, linear collections of gas within masses with mixed attenuation in or near the operative site. No air-fluid levels were present. In three patients, cultures of specimens obtained by aspiration were negative for pyogenic organisms. CONCLUSION: Retained oxidized cellulose can mimic an abscess on CT scans. Focal collections of air centrally located within a mass should alert the radiologist that oxidized cellulose may have been placed in the operative site, and an appropriate history should be sought.

Abscess↗
PubMed2004

The use of local agents: bone wax, gelatin, collagen, oxidized cellulose.

The use of local agents to achieve hemostasis is an old and complex subject in surgery. Their use is almost mandatory in spinal surgery. The development of new materials in chemical hemostasis is a continuous process that may potentially lead the surgeon to confusion. Moreover, the more commonly used materials have not changed in about 50 years. Using chemical agents to tamponade a hemorrhage is not free of risks. Complications are around the corner and can be due either to mechanical compression or to phlogistic effects secondary to the material used. This paper reviews about 20 animal and clinical published studies with regard to the chemical properties, mechanisms of action, use and complications of local agents.

Administration, Topical↗