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At least 37 records · Page 2Linked to original sources
PubMed1979

Cold stress influence on lung lecithin in the newborn rabbit.

Term, food-water deprived newborn rabbits exposed to a cold environment for 48 h demonstrated a significant decrease in total lung lipid (p less than 0.01), total triglyceride (p less than 0.001), total phospholipid (p less than 0.05), and total phosphatidylcholine (p less than 0.025). Disaturated phosphatidylcholine remained unchanged. Fatty acid methyl esters of total and disaturated phosphatidylcholine were not influenced by cold stress. Likewise, there was no alteration in pulmonary function as determined by deflation pressure-volume relationships.

Animals↗
PubMed1978

Swimming capacity of mice after prolonged treatment with psychostimulants. I. Effects of caffeine on swimming performance and cold stress.

A comparative study of the effects of a single dose of caffeine (50 microgram/g s.c.) and of 6-weeks treatment with 150 microgram/g p.o. caffeine/day on swimming capacity and resistance to cold exposure was performed in mice. In contrast to acute treatment, chronic treatment with caffeine greatly reduced the swimming capacity and diminished the ability of the animals to withstand cold stress. It could be shown by indirect means that the detrimental effect of the prolonged treatment with caffeine was not due to an accumulation of toxic levels of caffeine. Motor coordination was unaffected. There was no deficiency of metabolic substrates, since glycogen, and fat stores, and blood glucose, and fatty acid levels were not lower than in control animals. It is proposed that caffeine may interfere with the animals' ability to mobilize and spend metabolic substrates for energy requirements of skeletal muscle.

Animals↗
PubMed1978

Effect of a local cold stress on peripheral temperatures of Inuit, Oriental, and Caucasian subjects.

Male subjects comprised of six Inuit from Igloolik, N.W.T., and five Orientals and six Caucasians from Toronto, Ont., volunteered for tests to determine the effect of localized cold stress on peripheral temperatures. In each subject, skin temperatures of the right index finger, the arm, and the cheek, as well as blood pressure and heart rate, were measured before, during, and after foot immersion in water of 10 degrees C temperature for 10 min. There was an immediate decrease in finger temperature on foot immersion in all three subject groups; however, the Inuit finger temperatures recovered very quickly to control values, the Caucasian finger temperatures began to increase after decreasing for 7.5 min, and the Oriental finger temperatures decreased continuously during the foot immersion and remained cool even 10 min after the removal of the cold stimulus. The cold stimulus did not affect the cheek or arm temperatures of any of the groups. In all subjects, systolic and diastolic blood pressures and heart rates increased on foot immersion, gradually returning towards normal values. No intergroup differences were seen in these parameters.

Adult↗
PubMed1979

Effects of contingent versus yoked temperature feedback on voluntary temperature control and cold stress tolerance.

Twenty-four male internals (locus of control) and 24 externals were instructed to increase finger temperature under one of three conditions: (1) contingent feedback (CF), (2) yoked sham feedback (YF), or (3) no feedback (NF). Five 13-min training sessions were given. Feedback was then removed and subjects tested for voluntary temperature control. Finally, the cold pressor test, a laboratory analogue of natural cold stress, was administered under no-feedback conditions. Results demonstrated voluntary control of peripheral temperature following contingent feedback training, but not after yoked feedback temperature training. Contrary to expectation, the acquisition of voluntary control did not attenuate the stress response to thermal pain. Differences between internals and externals throughout the study were generally insignificant.

Biofeedback, Psychology↗
PubMed1977

The influence of a genetic change in egg production, body weight, fertility or response to cold stress on semen yield in the turkey.

Egg production and semen yield, sperm concentration and total sperm per ejaculate were positively associated in a line (E) selected for increased egg production. Semen yield was decreased in a line (F) selected for increased 16-week body weight in comparison to a randombred control population (RBC). The effect may be attributable to decreased egg production in this line, as another line (I), developed from the same RBC, which exhibited genetic increases in body weight but no reduction in egg production, did not differ significantly in semen yield from the RBC. Genetic increases in body weight reduced sperm concentration and total sperm per ejaculate. Genetic changes in average clutch length, total days lost from broodiness, fertility, and response to cold stress did not have a major influence on semen production in the turkey.

Animals↗
PubMed1978

Effects of cold stress on rats fed different levels of docosenoic acids.

Male Sprague-Dawley rats, 4 weeks old, were subjected to an ambient temperature of 4 C for periods up to 24 days and fed a synthetic diet containing one of the following oils: peanut oil (PO), rapeseed oil (RO), low erucic acid rapeseed oil (LO), and partially hydrogenated marine oil (HO), each at 20% w/w. A parallel experiment using the same oils was performed at room temperature (23 C). During cold stress, animals on the RO diet showed higher mortality than all other groups; all 20 animals in this group died within 5 days. At room temperature, however, all animals survived. The lipid accumulation in the heart reached its peak in all groups after 3 days and then gradually declined. The accumulation was most pronounced in the RO animals and coincided with the high mortality at 4 C. The fatty acid composition of the cardiac triglycerides reflected that of the diet, while the composition of the cardiac lecithin was only marginally modified.

Animals↗
PubMed2026

Genome-wide identification and evolutionary analysis of the ERF-VII gene family in the tea plant (Camellia sinensis) and functional characterization of CsRAP2.2 in response to cold stress.

The ERF-VII gene family, a critical branch of the AP2/ERF superfamily, is central to plant stress adaptation. However, its evolutionary history and function in tea plant (Camellia sinensis) remain unclear. Here, we performed integrated evolutionary, genomic, and functional analyses of ERF-VII genes across 14 plant lineages and 20 tea plant cultivars. The phylogenetic analysis revealed that ERF-VII proteins originated after vascular plant divergence, coinciding with the emergence of the N-terminal MCGGA/I motif linked to the oxygen-dependent N-degron pathway. Gymnosperms retained few conserved members, whereas angiosperms exhibited lineage-specific expansion-extensive in monocots via whole-genome duplication, moderate in eudicots with functional diversification. Pan-genome analysis across 20 tea plant cultivars further revealed varietal differences in ERF-VII gene distribution. Transcriptome profiling via the Tea Plant Information Archive identified CsRAP2.2 as a cold-inducible ERF-VII member with sustained expression under low-temperature stress. Functional assays demonstrated that silencing CsRAP2.2 reduced cold tolerance, while overexpression in tea leaves and heterologous expression in Arabidopsis thaliana enhanced cold tolerance by maintaining photosystem II efficiency, reducing membrane lipid peroxidation, and improving antioxidant capacity. Weighted gene co-expression network analysis positioned CsRAP2.2 as a regulatory hub integrating cold, hormone, and oxygen-sensing pathways. These results clarify the evolutionary trajectory of ERF-VII genes and establish CsRAP2.2 as a core cold-tolerance regulator in tea plant. These findings may inform future breeding of cold-resilient tea cultivars.

Camellia sinensis↗
PubMed2026

Genome-wide identification and cold-stress-responsive expression analysis of the NOX gene family in Cucumis melo.

NADPH oxidases (NOXs) are crucial enzymes for reactive oxygen species (ROS) generation in plants and play vital roles in growth, development, and stress responses. To elucidate the sequence characteristics of the NOX gene family and its low-temperature response patterns in melon (Cucumis melo L.), this study conducted genome-wide identification and expression profiling of NOX family members using bioinformatics analysis, RNA-seq transcriptome sequencing, and real-time quantitative PCR (RT-qPCR). The results revealed that eight NOX members were identified in the melon genome, distributed across six chromosomes. All members harbored conserved domains including Ferric_reductase, FAD_binding_8, NAD_binding_6, and NADPH_Ox, and the encoded proteins were generally basic and hydrophilic. Phylogenetic analysis classified the NOX proteins into five subgroups. Synteny analysis indicated the presence of only one pair of intraspecific duplicated genes in melon, which was under purifying selection. The promoter regions contained multiple hormone- and stress-responsive cis-acting elements, with CmNOX2 and CmNOX4 harboring low-temperature responsive elements. Following treatment at 4℃ for 24 h and 48 h, leaf relative electrolyte leakage (REL) increased from 28.33% to 42.67% and 52.67%, respectively; transcriptome analysis identified 5,633 and 6,882 differentially expressed genes (DEGs), respectively. Cold-responsive genes exhibited significant differential expression, with SLAC1 and CPK19 showing sustained upregulation. RT-qPCR results demonstrated that the expression of CmNOX2, CmNOX5, CmNOX6, and CmNOX7 was significantly downregulated after low-temperature treatment, whereas CmNOX4 expression was significantly upregulated at 48 h. Integrating promoter elements and expression characteristics, CmNOX4 may represent an important candidate gene involved in melon low-temperature response. This study systematically characterized the structure, evolution, and expression patterns of the melon NOX gene family, identified candidate genes responsive to low temperature, and provides a reference for further investigation into the mechanisms underlying melon cold adaptation.

Cucumis melo↗
PubMed1977

Diminished vascular reactivity to a cold stress in azotemic patients.

The integrity of the neurovascular reflex arc to a cold stimulus was evaluated by the determination of the response of the limb blood flow in fifteen azotemic patients. Seven of these patients became hypotensive during the course of renal failure despite comparable hemodialysis therapy. They showed a constant low blood pressure (mean blood pressure below 90 mmHg). The reactivity index (defined as the relative change at the 15th second of stimulus) was 15.9 +/- 14.4% for these hypotensive patients, and 35.7 +/- 12.0% for the remaining eight normotensive ones, while that of healthy subjects was 48.7 +/- 8.7%. The greatly diminished reactivity of the hypotensive patients could not be explained by humoral or hormonal factors. The dysfunction of somatic nerves of the vascular geometry could not be responsible for the difference. A dysfunction of adrenergic control of blood pressure was, therefore, strongly suggested.

Adult↗