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PubMed1991

Effect of damage to the teat end on the experimental induction of mastitis in dry cows with Corynebacterium pyogenes.

The teat ends of 12 dry cows were contaminated with Corynebacterium pyogenes. To determine whether a pre-existing (an)aerobic bacterial infection of the udder was a predisposing factor for a C pyogenes mastitis they included infected and uninfected quarters. Anaerobic bacteria could not be found and mastitis was not induced. When the teats were contaminated with C pyogenes after the teat ends had been injured 30 of the quarters became infected, and anaerobic bacteria were demonstrated in many quarters.

Animals↗
PubMed1977

Precipitating antibody against protease of Corynebacterium pyogenes in pigs.

Antibody in sera from pigs carrying an abscess associated with Corynebacterium pyogenes and healthy pigs was examined by the agar gel diffusion test. In the test, the concentrated culture fluid containing the protease of C. pyogenes was used as antigen. As a result, precipitating antibody was demonstrated in sera from 25 of 30 abscessed pigs and a few of the healthy pigs. When the relationship between precipitating antibody and protease was examined by the immunoelectrophoresis and gel filtration of the concentrated culture fluid, the antibody was shown in the same position as the protease. From the result, it was clear that the precipitating antibody was against the protease of C. pyogenes. All the proteases produced by 27 strains of C. pyogenes of porcine and bovine origin were serologically identical with one another. They were, however, serologically different from those of Staphylococcus aureus, Bacillus cereus, and B. subtilis. In the inhibition test, the proteolytic activity of C. pyogenes was inhibited by the serum of the abscessed pig. It was also inhibited by healthy pig serum. From the results, it seems that the determination of precipitating antibody may be useful for the diagnosis of C. pyogenes infection.

Abscess↗
PubMed1980

Chemically defined growth medium for Corynebacterium pyogenes.

A chemically defined medium and a relatively simple semidefined medium (SDM) which allow good growth of Corynebacterium pyogenes, a nutritionally fastidious animal pathogen, were described. The SDM contained glucose, trypticase, yeast extract, hemin, minerals, cysteine x HCl, and NaHCO3. To obtain a chemically defined medium, yeast extract in SDM was replaced with a defined mixture of nucleic acid bases, vitamins, amino acids, and trace minerals, and trypticase was replaced by myo-inositol (1 microgram/ml of medium).

Animals↗
PubMed1979

Diagnosis of Corynebacterium pyogenes infection in pigs by immunodiffusion test with protease antigen.

A protease antigen was prepared from the culture supernatant of Corynebacterium pyogenes by concentrating with a flash evaporator and ultrafiltration. It was adjusted to the concentration of 32 units by the single radial immunodiffusion with a tentative standard serum. In the immunodiffusion test, the antigen of 4 units reacted enough with sera having an antibody titer ranging from 1 to 128. As a result, it was decided that the antigen of 4 units should be used in the immunodiffusion test for the detection of protease antibody. By the immunodiffusion test, protease antibody was demonstrated in about 35% of 443 sera from pigs collected at random. The antibody titer showed the distribution of 2 peaks. The summits of the two peaks were seen at 4 and 32 of antibody titer, respectively. The valley between the two peaks was seen at 16 of titer. From the result, a diagnostic criterion of the immunodiffusion test was decided provisionally as follows: above 16 of antibody titer is positive, 1 to 8 suspect, and less than 1 negative. On the other hand, protease antibody was demonstrated in sera from 13 of 14 pigs carrying abscesses from which C. pyogenes had been isolated. Its titer was 8 (in 2 pigs), 16 (in 1), 32 (in 3), 64 (in 6), and 128 (in 1). From these results, it was proposed that the immunodiffusion test with protease antigen be used for the diagnosis of C. pyogenes infection in pigs.

Animals↗
PubMed1980

Certain characteristics of Corynebacterium pyogenes infection.

Isolation, characterisation and antibiotic sensitivity of 18 strains of Corynebacterium pyogenes from different animals have been reported. All the C pyogenes isolates uniformly differed from the typical strains of this species by the utilisation of trehalose and their failure to acidify maltose. The majority of the strains failed to grow in the presence of 0.1 per cent potassium tellurite. Tuberculosis-like lung lesion in a seven-day-old calf yielded one of the strains of C pyogenes. Histopathological changes in the calf lung have also been described.

Animals↗
PubMed1977

Failure to induce in rabbits effective immunity to a mixed infection of Fusobacterium necrophorum and Corynebacterium pyogenes with a combined bacterin.

Failure to induce in rabbits effective immunity to a mixed infection of Fusobacterium necrophorum and Corynebacterium pyogenes with a combined bacterin. Onderstepoort Journal of Veterinary Research, 44 (4), 253--2;6 (1977). Rabbits were immunized with alum-precipitated, oil adjuvant and an untreated bacterin composed of F. necrophorum and C. pyogenes. Immunized rabbits were challenged intradermally with a mixture of F. necrophorum and C. pyrogenes. Immunized rabbits were challenged intradermally with a mixture of F. necorphorum and C. pyrogenes. Initially a low level of initial transient resistance could be demonstrated but a solid immunity could not be established.

Animals↗
PubMedDate not supplied

Corynebacterium pyogenes. Its pathogenic mechanism in epidemic leg ulcers in Thailand.

There is a yearly outbreak of endemic leg ulcers in Thailand. Corynebacterium pyogenes, a pathogen to animals, is frequently isolated from the fresh lesions in addition to common pyogenic bacteria such as beta-hemolytic streptococci, mostly group A, and Staphylococcus aureus and Staphylococcus epidermidis. Although circulating titers of IgG and IgM anti-C. pyogenes antibodies were found to be very low in studied cases, intradermal skin test with C. pyogenes vaccine containing nonviable 10(5) microorganisms induced an erythematous reaction with maximum intensity at 6 hours; direct immunofluorescence showed granular deposition of C3 along the dermoepidermal junction at this time. Unexpectedly, the sites of such a skin test that subsequently underwent biopsy presented tender erythematosus induration 1 week later and developed granulomatous ulcerative lesions after 10 days in 11 of 15 patients. Radioimmunoassay for C5a and C5a of arginine demonstrated that C. pyogenes activated complement even in the absence of specific antibodies. These findings suggest that importance of skin injury followed by infection with C. pyogenes in the development of endemic leg ulcers, supporting our hypothesis that the infection of accidentally traumatized skin by C. pyogenes, which is carried by Oriental-eye flies, induces the granulomatous lesions of endemic leg ulcers.

Adolescent↗
PubMed1985

[Pharmacokinetics of amoxicillin trihydrate in sheep infected experimentally with Corynebacterium pyogenes and Escherichia coli].

A comparative experiment was carried out with sheep that were infected i/v and via the joints with Corynebacterium pyogenes and Escherichia coli, and with normal sheep left as controls. The pharmacokinetic parameters were determined of amoxicillin-trihydrate following its i/m application to all animals in a 20 percent oil suspension. It was found that there was delayed excretion of the antibiotic, and as a rule it was maintained in higher concentrations in the diseased animals. the differences were likely to be due to changes in the metabolic processes and to injury of the kidneys.

Amoxicillin↗
PubMed1974

Corynebacterium pyogenes and bovine abortion.

In the examination of bovine fetal material it was found that there was a significant increase in the proportion of mixed infections identified as the time between abortion and the collection of the samples increased. Examination of paired serum samples from abortions from which only Corynebacterium pyogenes was isolated revealed evidence of active infection in two-thirds, suggesting that C. pyogenes may have been acting as a primary abortifacient in these cases.

Abortion, Veterinary↗
PubMed1979

[Immunofluorescence tests for the detection of antibodies against Corynebacterium pyogenes and streptococci in blood serum and vaginal mucus of cattle].

Bacteriological tests were applied to cattle with endometritis and vaginitis. Included were cervical mucus samples and immunofluorescence tests to detect in that mucus as well as in blood serum antibody to Corynebacterium pyogenes and Streptococcus haemolyticus. The results pointed at intensive contact of the animals with the above pathogens and to their frequent occurrence in cervical mucus of cattle afflicted with endometritis and vaginitis. They also supported the assumption of localised antibody formation in the sexual organs or female cattle.

Animals↗
PubMed1978

Corynebacterium pyogenes septic arthritis with plasma cell synovial infiltrate and monoclonal gammopathy.

A chronic septic process developed in the right knee of an elderly man with advanced degenerative arthritis of both knees. Open exploration, culture, and biopsy of the joint found that the pathogen was Corynebacterium pyogenes and that the synovium was involved with a remarkable perivascular infiltrate of plasma cells. Serum protein electrophoresis demonstrated a prominent M component. Following antimicrobial therapy, the M protein level has gradually declined, and no evolution of multiple myeloma has become apparent. The findings are consistent with a benign monoclonal gammopathy and localized plasmacytic reaction in the knee associated with infection by an unusual diphtheroid organism.

Aged↗
PubMed1986

[Action of fenitrothion (Agria 1050) on the development of a surgical infection with Corynebacterium pyogenes in sheep].

Investigations were carried out on twelve Starozagorska breed sheep divided into two groups of 6 animals each. All sheep were treated with phenitrothion (Agria-50) at the rate of 300 mg per kg body mass, singly, by means of a stomach tube. At the first hour of treatment the sheep of the second group were injected with 3 cm3 broth culture of Corynebacterium pyogenes. The general condition, the manifestation of signs of toxicity, and some paraclinical indices were followed up. The animals of the first group exhibited symptoms of toxicity and changes in the paraclinical indices, which was characteristic of the weak form of the infection course. Those of the second group developed the disease at a rapid course, with affection of the general state, atony of the forestomach, substantial changes in the hemopoiesis, the enzyme activity, the glycogenesis process, and the blood picture (erythropenia, drop of the hemoglobin content, higher erythrocyte sedimentation rate, leukocytosis with neutrophilia, strong drop of plasmal and serum cholinesterase, hyperglycaemia). Results pointed to the fact that Agria-1050 intoxication aggravated the course of the supurative surgical infection.

Animals↗
PubMed1988

The effects of ovarian hormones and ACTH on uterine defense to Corynebacterium pyogenes in cows.

Ovariectomized cows were treated with either estrogen, progesterone or adrenogorticotropic hormone (ACTH). Each cow's uterus was inoculated with 1x10(6)Corynebacterium pyogenes organisms. The cows were evaluated by rectal examination for signs of uterine infection. Peripheral leukocytic phagocytosis was determined by chemiluminescence at the beginning (Day 4) and end (Day 21) of the experiment. Uterine cultures were obtained at the end. None of the estrogen-treated cows developed signs of uterine infection, but all the other cows did develop uterine disease. All the infected cows showed clinical improvement at the experimental end (Day 21). There were no differences between groups for leukocytic phagocytosis on Day 4, but on Day 21, values for progesterone-treated and control cows were similar but greater than those for estrogen or ACTH-treated cows, which were similar. Leukocytic phagocytosis values for all cows were lower on Day 21 than on Day 4. Most of the estrogen- and ACTH-treated cows had negative intrauterine cultures on Day 21 while most of controls and progesterone-treated cows had positive cultures.

Journal Article↗