SEARCH · PubMed Health

Results for “Curcuma”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources

PubMed1989

Randomized double blind study of Curcuma domestica Val. for dyspepsia.

Curcuma domestica Val. is a medicinal plant. It has been claimed to be effective for dyspepsia. The studies done so far showed no toxicity due to consuming Curcuma domestica Val. The plant has been found to contain volatile oil and curcuminoids which are believed to be the active ingredients. The objective of the study was to test the efficacy of Curcuma domestica Val. rhizome for treatment of dyspepsia compared with a placebo and flatulence in a multicenter, randomized, double-blind trial carried out in one provincial and 5 community hospitals. One hundred and sixteen adult patients who had acid dyspepsia, flatulent dyspepsia, or atonic dyspepsia were included in the study. Forty-one (41) patients were in the placebo group, 36 and 39 were in the flatulence and Curcuma domestica Val. groups respectively. Each patient received 2 capsules of placebo or study drugs 4 times a day for 7 days. Each patient was then assessed for symptoms response, side effects and satisfaction. Ten patients did not participate in the follow-up. The baseline characteristics of the patients among the three groups were not significantly different. Fifty-three (53) per cent of the patients receiving placebo responded to the treatment whereas 83 per cent of the patients receiving flatulence and 87 per cent of patients receiving Curcuma domestica Val. responded to the treatment. The differences in efficacy between placebo and active drugs were statistically significant and clinically important. Mild and self-limited side effects were observed at similar frequency in the three groups. About 50 per cent of the patients in each group were satisfied with the treatment they received.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed2002

Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits.

OBJECTIVE: This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. METHODS AND RESULTS: Two experimental groups of male New Zealand White rabbits, a control group and a curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower alpha-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. CONCLUSIONS: Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in rabbits fed a high cholesterol diet.

Animals↗

PubMed2001

Molecular analysis of medicinally-used Chinese and Japanese Curcuma based on 18S rRNA gene and trnK gene sequences.

Curcuma drugs have been used discriminatingly for invigorating blood circulation, promoting digestion, and as a cholagogic in China. However, there is confusion about the drug's botanical origins and clinical uses because of morphological similarity of Curcuma plants and drugs. In order to develop an ultimate identification, molecular analysis based on 18S rRNA gene and trnK gene sequences were performed on 6 Curcuma species used medicinally in China and Japan. The 18S rRNA gene sequences were found to be of 1810 bps in length. In comparison with the common sequence of C. longa, C. phaeocaulis, C. wenyujin and C. aromatica, that of C. kwangsiensis had one base substitution, and the same base difference was observed between the Chinese and the Japanese populations of C. zedoaria. The trnK gene sequences were found to span 2698-2705 bps. There were base substitutions, small deletions or insertions at some sites between the trnK coding region and matK region among each species. Based on the base substitutions, C. zedoaria and C. kwangsiensis specimens were divided into two groups, respectively. An identical sequence was detected in C. phaeocaulis and in the Chinese population of C. zedoaria, as well as in the Japanese population of C. zedoaria and in one group of C. kwangsiensis with a purple-colored band in leaves. New taxonomic information to be used for authenticating Curcuma drugs was obtained.

Curcuma↗

PubMed2004

Application of single-nucleotide polymorphism analysis of the trnK gene to the identification of Curcuma plants.

We previously found that Curcuma plants and drugs derived from Curcuma longa, C. phaeocaulis, C. zedoaria, and C. aromatica could be identified by the nucleotide differences at two sites and the existence of a 4-base indel on trnK gene. In this paper, based on species-specific nucleotide sequences, the application of a new method, single-nucleotide polymorphism (SNP) analysis was investigated to identify Curcuma plants more conveniently. First, three types of reverse primer were synthesized in different lengths, 34 mer, 26 mer, and 30 mer, to anneal the template DNAs from each species at sites immediately upstream from substitution positions 177 and 645, and at the site including the 4-base insertion from 728 to 731, respectively. After single-base extension reaction of these primers using fluorescent-labeled ddNTPs and PCR products of the trnK gene region as template, the resulting products were detected using an ABI PRISM 310 Genetic Analyzer. The electrophoretogram showed three or two peaks at different positions depending on the 27 mer, 31 mer, and 35 mer product lengths. Each peak was derived from the incorporated fluorescent-labeled ddNMPs complementary to template nucleotides at positions 645, 724, and 177, respectively. C. phaeocaulis showed three peaks of ddCMP, ddAMP, and ddAMP. The other three species showed two peaks derived from 27 mer and 35 mer products: peaks of ddCMP and ddAMP in C. longa, those of ddCMP and ddTMP in C. zedoaria, and those of ddTMP and ddAMP in C. aromatica. Thus SNP analysis to identify four Curcuma plants was newly developed.

Curcuma↗

PubMed1999

[Determination on chemical constituents of Curcuma L. produced in China].

OBJECTIVE: To provide some valuable information for the research on species systematization and quality standardization of Curcuma drugs. METHODS: Colorimetry, TLC-colorimetry and water vapour distillation were used to determine the contents of curcuminoids, curcumin and essential oils of 34 samples of Curcuma produced in China. RESULTS AND CONCLUSION: The contents of curcuminoids and curcumin are different upto an extent of over 100 times among the varieties of Curcuma, and those of essential oils to an extent of 6 times. But there is little difference in the samples of the same species from different producing areas. There is also an obvious correlativity between the contents of curcuminoids and essential oils in the varieties of curcuma.

Curcuma↗

PubMed1998

[Effects of Curcuma phaeocaulis on learning and memory and lipid peroxide in mice].

Nine months mice were inoculated and the method of water maze test and lipid peroxide determination to study the effects of extract of Curcuma phaeocaulis Valeton on learning and memory ability and retarding of senescence. Results showed that in water maze test the time for the group with Curcuma phaeocaulis Valeton needed from initial position to the end was significantly shortened compared with old control. The error numbers for the group of Curcuma phaeocaulis Valeton were significantly decreased compared with old control after starting experiment for 18 days and 24 days and for 35 days no significance difference was showed between groups. The levels of brain, liver and red blood cells lipid peroxide in the group with Curcuma phaeocaulis Valeton were considerably lower than old control, hemoglobin content was considerably increased than old control.

Aging↗

PubMed2004

[Histological and morphological studies on leaves of Curcuma in China].

OBJECTIVE: To provide some new evidences for the classification and identification of medicinal materials of Curcuma. METHOD: The optical microscope and electronic microsccopic scaning were used to characterize the leaves of Curcuma. RESULT AND CONCLUSION: There were no obvious histological and morphological differences among the leaves of Curcuma. But the differences in the hair distribution, stoma density and size , shape and size of epidermic cells could be considered to be the main features for the microscopic identification of leaves of Curcuma.

China↗

PubMed2006

[Experimental study on rat model of endometriosis treated with tamoxifen and rhizoma curcumae oil].

OBJECTIVE: To evaluate the therapeutic effect of Tamoxifen in conjunction with a cell apoptosis contributor--Rhizoma curcumae oil on the rat endometriosis models. METHODS: The rat endometriosis models were established and were randomly assigned into the control group, Tamoxifen group, Alarelin (GnRHa) group, and the group of Tamoxifen (by gastrogavage) plus Rhizoma curcumae oil (by intraperitoneal injection). After 4 weeks of treatment, the growth of ectopic endometrial implants was observed; then eutopic and ectopic endometria were excised in preparation for HE staining and streptavedin-peroxi-dase immunohisto chemical analysis. RESULTS: After treatment, the volume of the ectopic implants of each treatment group was markedly smaller than that of control and before treatment (P < 0.05); the score of VEGF showed significant difference when each treatment group was compared with control (P < 0.05). The score of VEGF exhibited marked difference between Tamoxifen group and Alarelin (GnRHa) group, between Tamoxifen group and Tamoxifen plus Rhizoma curcumae oil group (P < 0.05). CONCLUSION: Tamoxifen in conjunction with Rhizoma curcumae oil could decrease markedly the volume and VEGF expression of ectopic implants.

Animals↗

PubMed2006

[Comparison of volatile oil chromatographic fingerprints of rhizoma curcumae longae and rhizoma wenyujin concisum].

To explore the same and difference of chemical components between the chromatographic fingerprints of volatile oil of Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum, the chromatographic/spectroscopic data of fingerprints were comparative analyzed using modified window target-testing factor analysis method. The results of comparisons showed that ten chemical components present in Rhizoma Curcumae Longae are absent in Rhizoma Wenyujin Concisum, while nine chemical components are present in Rhizoma Wenyujin Concisum but absent in Rhizoma Curcumae Longae. Also, nine common components are both present in Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum.

Chemistry Techniques, Analytical↗

PubMed1989

[Determination of boric acid in biological materials by curcuma paper].

The field of legal medicine has seen a recent increase of poisoning by boric acid and, in cases of emergency, a simple method of making a qualitative analysis of the boric acid content is a necessity. Thus, we have examined curcuma paper (turmeric paper) to see if it can provide a qualitative analysis of the boric acid content in biological materials, so as to identify cases of poisoning. It was found that curcuma paper can provide a preliminary analysis of the quantitative content of boric acid, and that about 0.1 mg/ml of boric acid can be determined. The steps for this testing method follow. First, either blood or urine is acidified with a 6 N concentration of hydrochloric acid, i.e., in the case of urine, 0.5 ml of urine is added to 0.1 ml hydrochloric acid, and for blood, 0.5 ml of blood is added to 0.2 ml hydrochloric acid. If the sample is not sufficiently acidic, more hydrochloric acid is added. Next, a drop of the sample is placed on the curcuma paper and, after drying at room temperature, a red stain results if boric acid is present. (Rosocyanin is formed by the reaction of boric acid and protonated curcumin). Then, a 1 N concentration of sodium hydroxide is dropped onto the stained place, and if rosocyanin is present, the stain will turn blue. Informatively, to make curcuma paper, filter paper (No. 2) is soaked in a saturated curcumin/ethanol solution and then air dried.(ABSTRACT TRUNCATED AT 250 WORDS)

Boric Acids↗

PubMed1993

Studies on the cobra neurotoxin inhibiting activity in an extract of Curcuma sp. (Zingiberaceae) rhizome.

A study was carried on the mode of action and some properties of a cobra neurotoxin inhibitor found in the extract of Curcuma sp. (Zingiberaceae). When the principal postsynaptic neurotoxin (STX) of the Thai cobra (Naja naja siamensis) was mixed with an aqueous extract of Curcuma sp. rhizome, the STX was inactivated as tested in mice or in vitro using a rat hemidiaphragm preparation. The 'neurotoxin inhibitor' ('NTxI') was found only in the water insoluble fraction of the rhizome extract. Using radioactively labeled neurotoxins, 125I-STX and 3H-STX, it was demonstrated that the neurotoxin did not form a stable complex with the 'NTxI'; the inactivated neurotoxin remained in the supernatant of the reaction mixture. After inactivation by 'NTxI', the STX exhibited an unchanged molecular weight as judged by SDS-polyacrylamide gel electrophoresis and an unchanged isoelectric point in isoelectric focusing. Extraction of the Curcuma sp. rhizome with at least 0.2% Triton X-100 resulted in solubilization of a component capable of forming a soluble and stable complex with 3H-STX. By column chromatography on Sephadex G-200 in the presence of 0.1% Triton X-100, the toxin-binding compound was shown to have a molecular weight of about 150 kDa. This 150 kDa component was obtained by Triton extraction of the water-insoluble fraction, and much less from the water soluble fraction, of Curcuma sp. rhizome. It did not possess any carbohydrate side-chain capable of binding the lectin Concanavalin A. The time course of the 150 kDa-3H-STX complex formation was extremely slow (approx 22 hours).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed2006

Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography.

A high-performance liquid chromatography coupled with diode array detection (HPLC-DAD) and pressurized liquid extraction was developed for simultaneous quantitative determination of 11 characteristic compounds, including curcumenone, curcumenol, neocurdione, curdione, isocurcumenol, furanodienone, curcumol, germacrone, curzerene, furanodiene and beta-elemene, in rhizomes of three species of Curcuma. The analysis was performed on an ODS C18 column. The mobile phase consisted of (A) water and (B) acetonitrile using a gradient elution. The peaks were monitored at both 214 nm and 256 nm. All calibration curves showed good linearity (r2 > 0.9996) within test ranges. This method showed good repeatability for the quantification of these eleven components in three species Curcuma rhizomes with intra- and inter-day variations of less than 1.57% and 1.98%, respectively. The validated method was successfully applied to quantify 11 investigated components in eighteen samples of three species of Curcuma, which is helpful to control their quality.

Acetonitriles↗

PubMed1991

Pharmacology of Curcuma longa.

The data reviewed indicate that extracts of Curcuma longa exhibit anti-inflammatory activity after parenteral application in standard animal models used for testing anti-inflammatory activity. It turned out that curcumin and the volatile oil are at least in part responsible for this action. It appears that when given orally, curcumin is far less active than after i.p. administration. This may be due to poor absorption, as discussed. Data on histamine-induced ulcers are controversial, and studies on the secretory activity (HCl, pepsinogen) are still lacking. In vitro, curcumin exhibited antispasmodic activity. Since there was a protective effect of extracts of Curcuma longa on the liver and a stimulation of bile secretion in animals, Curcuma longa has been advocated for use in liver disorders. Evidence for an effect on liver disease in humans is not yet available. From the facts that after oral application only traces of curcumin were found in the blood and that, on the other hand, most of the curcumin is excreted via the faeces it may be concluded that curcumin is absorbed poorly by the gastrointestinal tract and/or underlies presystemic transformation. Systemic effects therefore seem to be questionable after oral application except that they occur at very low concentrations of curcumin. This does not exclude a local action in the gastrointestinal tract.

Animals↗

PubMed1998

[Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry].

The study of chemical constituents of the volatile oil from Curcuma longa is reported. The volatile oil was extracted by steam distillation. Fifteen components in the oil were separated and identified by gas chromatography-mass spectrometry(GC/MS). The results were elucidated based on the NBS standard mass spectral data. The total ion current chromatogram showed their mass fraction by normalization method. alpha-curcumene, alpha-zingiberene, 1,8-cineole and zerumbone, which had been reported before were found in Curcuma longa volatile oil, but 1-(3-cyclopentylpropyl)-2,4-dimethylbenzene, beta-sesquiphellandrene, germacrene etc identified simultaneously in the oil had never been reported. The major chemical constituent of the volatile oil from Curcuma longa is alpha-curcumene.

Curcuma↗

PubMed1999

[A study on soil suitability for growth of rhizome of Curcuma longa L].

OBJECTIVE: To seek for the type of soil that influences favorably the yield and quality of Curcuma longa. METHOD: Field contrast control experiment, correlation analysis, path analysis and cluster analysis were used. RESULT: The rhizome yield and quality of Curcuma longa. varied greatly with the types of soil texture. There are clear correlations among the soil factors, as well as between the soil factors and the rhizome yield and quality of the plant. A regression equation of the rhizome yield and soil factors has been built up. CONCLUSION: The soil suitable for growing Curcuma longa. can be classified into three types according to the results of correlation analysis and cluster analysis.

Curcuma↗

PubMed1999

[Random amplified polymorphic DNA analysis on Curcuma wenuujin and C. sichuanensis].

OBJECTIVE: To discuss the problem of classifying Curcuma for Medical purposes. METHOD: RAPD was used to detect the DNA polymorphism within and among Curcuma wenyujin, C. sichuanensis and C. aromatica. RESULT: It is hard to differentiate between C. wenyujin and C. sichuanensis from the DNA level. The relationship between C. wenyujin and C. aromatica was also analyzed. CONCLUSION: Based on the morphological and chemical data, it is suggested that these two species should be combined into one and that classification based on peduncle central or peduncle lateral may not be right. This method will help to some degree to solve the problem of certifying the medicinal plant Curcuma.

Curcuma↗

PubMed2000

[Studies on antiplatelet aggregation and anticoagulant action of Curcuma phaeocaulis].

OBJECTIVE: To study the effects of Curcuma phaeocaulis Valeton on platelet aggregation and anticoagulant action. METHODS: Antiplatelet aggregation and anticoagulant action of Curcuma phaeocaulis Valeton of mice is observed in platelet aggregation and coagulant time. RESULTS: The experimental results show that Curcuma phaeocaulis Valeton can inhibit platelet aggregation, prolong time of mice coagulation. CONCLUSION: Antiplatelet aggregation and anticoagulant action of processed products with vinegar is the most powerful.

Animals↗

PubMed2002

[Study on the effect of Rhizoma Curcuma Longa on gastrin receptor].

By the method of receptor combination, effects of the active constituents in Rhizoma Curcuma Longa and Radix Curcumae were studied. The results showed that Rhizoma Curcuma Longa probably include the excitant or antagonist of gastrin receptor. And the inhibitory intensity was shown as followed: parts of ethyl acetate > parts of methanol > parts of ether > parts of volatile oil, root tuber > rhizome.

Animals↗