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PubMed1991

Wheezing in a commercial diver due to disinfectant.

A case is described of a saturation diver with no previous history of asthma who repeatedly developed work-related symptoms of asthma at pressure, which appear to be causally related to the use of dichlorophen as a disinfectant agent. Although challenge tests were negative, suggesting that dichlorophen may have been acting as an irritant rather than as a sensitizer, the symptoms were abolished by the use of an alternative disinfectant agent. The potential importance of this effect in a diver is discussed, and the case highlights the importance of the use of nontoxic agents in the diving environment.

Adult↗
PubMed1984

Entamoeba histolytica: inhibition in vitro by bithionol of respiratory activity and growth.

Endogenous and 2-propanol-supported respiration of intact trophozoites of of Entamoeba histolytica (stain HM-1:IMSS) were inhibited by bithionol, an effective chemotherapeutic agent for some trematode and cestode infections in humans. Dichlorophene and hexachlorophene also inhibited 2-propanol-supported respiration of the parasite. In contrast, ethanol formation by E. histolytica extract in the presence of N2 was scarcely inhibited by bithionol. The compound also inhibited in vitro growth of axenic (HM-1 strain) and polyxenic (strain HJ-1:KEIO) amoebae in culture. It took less than 24 hr to kill and disrupt virtually all amoebae of either strain with 0.28 mM bithionol. Omission of bovine serum from BI-S-33 medium resulted in considerably less disruption of HM-1 strain amoebae by the compound. However, organisms that looked undisrupted were strained with trypan blue. Moreover, the number of amoebae incubated for 10 min in the serum-free BI-S-33 medium containing 0.14 mM bithionol did not increase, even after incubation for 24 hr following replacement of the experimental culture fluid with fresh complete BI-S-33 medium free of the compound. These findings suggest that, although serum appears to diminish the antiamoebic action, some halogenated bisphenols (in particular bithionol) may be useful for treatment of amoebiasis.

1-Propanol↗