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Normal values in clinical electrooculography. V. Variability within and between eyes.

Three EOG's (DC amplified 30-degree saccades, slightly modified Arden schedule) were recorded at weekly intervals from each of 16 normal human eyes (eight subjects). The light induced potential rise of the dark-adapted eye, the Arden ratio and the Gliem ratio entered into the analysis of intra- and inter-eye variation. The 95% confidence intervals for the mean parameter values of each eye were: +/- 59 muV (mean = 415 muV) for the light induced potential rise, +/- 22 (mean = 260) for the Arden ratio and +/- 10 (mean = 92) for the Gliem ratio. The intra-eye variability was compared to earlier studies of the day-to-day variation of the ERG by means of a dimensionless index; no substantial differences were found. Highly significant differences in the EOG parameter levels existed between the subjects, whereas the variation between right eye and left eye means in the individual subjects was ise respects. The primarily qualitative nature of the EOG in the present version is emphasized by the present results.

Adult↗

Normal values in clinical electrooculography. IV. Analysis of two dimensionless EOG parameters and their relation to other variables.

Two EOG parameters - The Arden ratio (A) and an expression devised by Gliem (G) - from a sample of normal human subjects are studied. Their relations to the EOG potential and time parameters and to sex, age, pupillary diameter, degree of iris pigmentation, refractive error and axial length, ocular protrusion and interpupillary distance were assessed. Right eye and left eye distributions were congruent, although individual differences were sometimes appreciable, especially in the case of G. The two ratios were positively correlated and both showed a negative correlation to the interval between the dark trough and the light peak. Correlations to the EOG potential parameters, especially the light induced potential rise of the dark adapted eye, were also established. In the case of A, a higher level was disclosed in the male half of the sample. A negative age correlation, predominant in the female part of the sample, characterized both ratios. The two ratios were positively correlated to the pupil diameter, negatively correlated to the degree of refractive errror, and positively correlated to the degree of ocular protrusion. The consequences for the clinical EOG test are discussed, and it is concluded that the present EOG procedure is a qualitative rather than a quantitative test.

Adolescent↗

Comparative study of posturography and electrooculography in at-risk subjects for Huntington's disease.

A simultaneous blind study of posture and eye movements was undertaken in 9 subjects at risk for Huntington's disease. After quantitative evaluation of the postural and electrooculographic abnormalities, the subjects were subdivided into subgroups, and the results were compared to test the relationship between the two methods. There was a significant correlation between the two evaluations. 5 of the 9 patients had evaluation scores which reflected abnormalities similar to those observed in patients suffering from Huntington's disease. These preliminary results suggest that posture and eye movement recordings could be tested for their predictive value in Huntington's disease.

Adolescent↗

Automated electrooculography--a microprocessor application example.

An Intel 8080 microprocessor is used to control the running, and also analyse the results of a clinical test, the electrooculogram. The processor provides a moving stimulus using a strip of thirty-two light emitting diodes. From electrodes attached medial and lateral to the eyes, the sinusoidal signals generated by the stimulated lateral eye movements are monitored, digitised by the processor and the peak values stored for subsequent analysis. Results are plotted both numerically and graphically each minute of the test on a standard teletype. Throughout the test, systems faults are recognised and appropriate error messages produced. The test is automatically terminated and results calculated when sufficient data has been collected. The development of this system and the advantages of a microprocessor in this application are discussed.

Computers↗