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PubMedDate not supplied

[Hypersensitivity vasculitis caused by ethyl biscoumacetate].

A case report of a 61-year-old patient with hypersensitive vasculitis caused by ethylbiscumacetate is presented. After the implantation of the artificial aortic valve the patient was treated with medigoxine, furosemide, dipiridamole, disopiramide, potassium chloride and ethylbiscumacetate. Among these drugs furosemide and ethylbiscumacetate are reported to cause hypersensitive vasculitis. On the basis of the past medical history, clinical and histological findings furosemide was ruled out as a causative agent. The diagnosis was confirmed by the skin biopsy and finding of a normal biologic activity of protein C. The discontinuance of all previous drugs and administration of methylprednisolone led to improvement in the skin lesions of the patient. The need for continuous anticoagulant therapy was the reason for fepromarone to be given, achieving good anticoagulant effect, without any side effects. According to the criteria of Karch and Lasagna the degree of connection between drug use and side effects in this case belongs to the category "probable".

Ethyl Biscoumacetate↗
PubMed1987

Protective effects of sodium bicarbonate on murine ochratoxicosis.

The protective effect of sodium bicarbonate (NaHCO3), a urine modifier, to alleviate murine ochratoxicosis was investigated. The study included two trials. Urinary pH was altered before oral administration of ochratoxin A (OA) in Trial 1, and animals were given combined doses of OA and ethyl biscoumacetate (Eb) in Trial 2. Acute toxicity of OA as measured by LD50 values was reduced by 23% and 20% in rats treated with NaHCO3 for Trials 1 and 2 respectively. Bicarbonate-treated rats dosed with 20 mg/kg OA or with a combination dose of OA at 17 mg/kg and Eb at 50 mg/kg, had a lower frequency of histological lesions in kidneys, liver, lung, spleen and heart. Two types of heart lesions found in the present study are described.

Animals↗
PubMed1988

[Prevention of thromboembolic complications during total hip arthroplasty by pre- and postoperative heparinotherapy with adapted doses. Apropos of 356 cases].

From January 1980 to July 1987, a continuous series of 356 total hip replacement underwent preventive treatment of subcutaneous Heparin, prescribed in adapted doses, both before and after surgery, and relayed at the 7th postoperative day by Ethyl Biscoumacetate. This medication was continued for 45 days. Modern methods of detection were used to detect thromboembolic complications: up to the 7th day radioactive labeled Fibrinogen and, at the slightest hint of problem, phlebocavography of the lower limbs. The established procedure made it possible to lower significantly the rate of phlebothromboses to 14 cases (3.9%) of which 3 (0.8%) developed non lethal pulmonary embolisms. The surgical site revealed an hematoma in 5% of the case, of which 1.4% had to be subjected to a surgical relief. Of the 4 deaths observed in this series, two resulted from the anticoagulant preventive method. The biological monitoring disclosed a lasting fall in the Antithrombin III in the three days following the operation and significant drop in the coagulation tests between the 4th and 6th day in the case of the patients who were to develop a thromboembolism.

Adolescent↗
PubMedDate not supplied

Liquid chromatographic determination of coumarin anticoagulants in tablets.

A simple and rapid liquid chromatographic method is described for the qualitative and quantitative determination of 5 coumarin anticoagulants in tablet composites and individual tablets. Analyses are carried out on a C18 reverse phase column using tetrahydrofuran-methanol-water-acetic acid (35 + 10 + 65 + 0.1) as mobile phase and photometric detection at 311 nm. The coefficients of variation for 10 consecutive injections of a mixed standards solution ranged from 0.28% for ethyl biscoumacetate to 0.78% for acenocoumarol. Standard recoveries were as follows: acenocoumarol, 99.3%; dicumarol, 99.6%; phenprocoumon, 101.6%; and warfarin sodium, 99.0%. The method was linear between 2 and 8 micrograms of drug injected. Assay results agreed favorably with those of the USP XX methods for dicumarol, phenprocoumon, and warfarin, and the NF XIV method for acenocoumarol. In addition, close correspondence was found with the results previously reported for the same drugs by a semiautomated spectrophotometric method. The content uniformity testing of individual 50 mg dicumarol tablets and 5 mg warfarin sodium tablets by the proposed method gave average (SD) values of 100.32% (0.64) and 101.00% (0.14), respectively, whereas these values were 101.60% (1.81) and 101.80% (0.18), respectively, by the method of USP XX.

Anticoagulants↗
PubMed1978

[Use of new Bulgarian hydrosol vitamin preparations in veterinary medicine].

Studied were the new Bulgarian hydrosol preparations Hydro-AD3EC, Hydro-AD3EK, and Hydro-EC. Their tolerance was investigated with the use of albino Wistar rats, the resorption and retention (by their liver content) of retinol and d, 1-alfa-tocopherol was investigated in young broiler chickens, the resorption of ascorbic acid was followed up in White English layers, the antihemorrhagic effect of Hydro-AD3EK was studied in rats with experimentally induced hemorrhagic diathesis offering 30 mg ethyl biscoumacetate (pellentan tablets) with the feed. It was found that the oral application of the first three hydrosol preparations to albino rats at the rate of 12.5 cm3/body weight (equal to 10-15 effective doses for birds) did not produce toxic effects. The retinol and d, 1-alfa-tocopherol constituents of AD3EC and AD3EK, given with the drinking water to birds, were well resorbed and were deposited in the liver. Fuller resorption was observed with the use of AD3EC. The ascorbic acid of AD3EC and AD3EK when these were offered per os to adult chickens was resorbed quickly, which was better expressed with AD3EC. AD3EK in oral application to rats produced antihemorrhagic effects. The use of these preparations in a prophylactic scheme with young broilers shortened the fattening period and improved the feed conversion.

Absorption↗