The fallopian tube of the sheep. II. The influence of progesterone and oestrogen on the secretory activities of the fallopian tube.
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Interstitial fallopian tube obstruction (IFTO) occurs in 15% of hysterosalpingograms (HSG) performed for infertility. Conventional HSG or laparoscopy may not differentiate cornual spasm or other temporary cause from true obstruction. We used transcervical cannulation of the proximal oviduct with a 3-F Teflon catheter and flexible guidewire 0.018 inch (0.043 cm) in diameter under hysteroscopic or fluoroscopic guidance to evaluate IFTO in 28 patients. Fluoroscopic catheterization techniques with selective salpingography demonstrated patency in 84% of obstructed tubes. Hysteroscopic cannulation with direct visualization by laparoscopy or laparotomy was successful in 92%. In one patient, perforation of the isthmus occurred without sequelae. Transcervical coaxial cannulation of the proximal oviduct is an effective method for evaluating cornual obstruction.
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Carcinoma of the fallopian tube is the least frequent tumor of the female genital tract. During a 27 year period, 34 patients with adenocarcinoma of the fallopian tube were treated at the University of Michigan Medical Center. Eight of 34 of the patients were found to have early second primary tumors during the work-up. The over-all two year and five year survival rates were 52 and 20 per cent, respectively. Results of our review of this group of patients would indicate that postoperative irradiation of the pelvis with more than 50 Grey in five weeks increased the five year survival rate of patients with disease confined to the fallopian tube.
Rabbit fallopian tubes were used as models to demonstrate the delayed effects of the argon laser wavelength on tissue. Power density, energy density, and velocity were all variables in the experiment. Three groups of ten rabbits were sacrificed two at a time, on days 0, 5, 10, 15, and 20. The results clearly showed delayed tissue changes associated with fibrosis. Mathematical and theoretical comparisons of the argon laser to the carbon dioxide laser help express the advantages and disadvantages of the use of the argon laser in fallopian tube surgery. The return of organ function with respect to time has possible significance to studies of human fallopian tube surgeries.
Ultrasound-guided fallopian tube catheterization was performed in seven women a total of 14 times. The women had normal-appearing fallopian tubes at hysterosalpingography and received sperm via the catheter as a way to overcome their inability to conceive. Techniques similar to those used for fluoroscopically guided fallopian tube catheterization were used. Forty-three percent of fallopian tubes were successfully catheterized.
In the fallopian tube there are three main epithelial cell types, i.e., ciliated and nonciliated (or secretory) cells and intercalary, or peg, cells. An additional cell type has been considered either a wandering or a progenitor cell. Our morphologic and histochemical study shows a close similarity between a fourth cell type in the fallopian epithelium and the endometrial granulocytes (K cells). It is suggested that the two cells might be of an identical nature and that granulocytes could be ubiquitous in the entire Müllerian tract.
Successful fallopian tube catheterization for diagnosis or treatment of infertility combines hysterosalpingographic and angiographic techniques. An improvement in the catheterization strategy was developed so that angled, tortuous, or more distally obstructed fallopian tubes could be catheterized. In 22 patients, 38 fallopian tubes were catheterized by using this strategy. In nine tubes (24%), forceful ostial injection alone of contrast material was able to open and/or depict the fallopian tube. In 13 tubes (34%), a discrete obstruction was recanalized by using the standard fallopian tube catheterization set. In 12 tubes (32%), successful recanalization required the use of a softer, tapered guide wire and catheter. In four tubes (10%), recanalization was unsuccessful.
In human fallopian tubes, secretory cells made up about 70% and ciliated cells most of the remainder of the epithelium. At the light microscopic level, lectin-peroxidase conjugates and other methods demonstrated on secretory cells a surface glycocalyx containing glycoconjugates with fucose residues, terminal sialic acid-beta-galactose disaccharides, and sulfate esters. Secretory cells also expressed ABO blood group antigens, on their surface, staining for terminal alpha-N-acetylgalactosamine and alpha-galactose in blood group A and B subjects, respectively. The glycocalyx coating the cilia of all ciliated cells contained an acidic glycoconjugate with terminal sialic acid-beta-galactose disaccharides. Ciliated cells ranged from strongly positive to negative in staining for blood group ABO antigens, fucose, and terminal beta-galactose. The glycocalyx on the surface of cilia differed from that on the secretory cell surface in lacking sulfate esters and possessing terminal sialic acid-beta-galactose disaccharides cytochemically unlike those on secretory cells. Cytoplasmic granules, presumably secretory in nature, stained for blood group antigen in secretory cells of some specimens. Two lectin conjugates with affinity for the core region of N-glycosidically linked oligosaccharides revealed bodies interpreted as lysosomes in ciliated and secretory cells of most specimens. The latter lectins also stained mast cells intensely, presumably because of affinity for N-acetylglucosamine. The luminal surface of endothelial cells stained heavily for fucose and for a terminal sialic acid-beta-galactose disaccharide like that on the surface of cilia. The staining for carbohydrate did not vary qualitatively, and the ratio of secretory to ciliated cells did not differ with the phase of the menstrual cycle. The salpingeal epithelium in two patients with inactive endometrium did not differ from the others. The epithelium in a specimen from a patient with uterine fibroids showed foci of mucous metaplasia, containing a nonsulfated sialylated glycoconjugate. At the electron microscopic level, fucosylated glycoconjugate was visualized with a specific lectin conjugate on the surface of the secretory cells but not on the surface of ciliated and endothelial cells. Infrequent cytoplasmic granules containing mucosubstance apparently provided the cell mechanism in secretory cells for collecting and transporting material from biosynthetic sites to the glycocalyx.(ABSTRACT TRUNCATED AT 400 WORDS)
Carcinoma of the fallopian tube is the least common of the gynecologic malignancies. Because of its rarity and the absence of typical symptoms, preoperative diagnosis is seldom made. Patient as well as physician delay in diagnosis is often considerable. There are no reliable laboratory aids available to enhance the discovery of this tumor. However, routine periodic pelvic examinations with laparoscopic examination of any significant adnexal enlargement in postmenopausal women should decrease the discovery time. Certainly, unexplained vaginal discharge or bleeding particularly when associated with a pelvic mass, should increase one's suspicion. Conventional surgical treatment can be curative if the tumor has not exceeded the confines of the tube and has not involved the serosa. Regardless, the prognosis for patients with primary carcinoma of the fallopian tube is grim.
Twelve cases of fallopian tube dilatation were diagnosed in 10 patient by using endovaginal sonography. The diagnosis was confirmed by surgery in seven patients and by hysterosalpingography in three. A tubular shape was present in every case. Other sonographic features included a well-defined echogenic wall, a folded configuration, and linear echoes protruding into the tube lumen. Dilated tubes were distinguished from bowel loops by a lack of peristaltic activity and from pelvic veins by a lack of moving low-level echoes on real-time sonography. We conclude that the findings of dilated fallopian tubes on endovaginal sonography are sufficiently characteristic to allow the diagnosis to be made with this technique.
An unsuccessful human fallopian tube transplant is reported. A microsurgical technique is described which initially secured a viable transplant. However, the allograft subsequently died, probably as a result of rejection. Immunosuppression of the patient caused no complications or difficulties, the donor sharing one HL-A haplotype with the patient. The operative procedure, the risks of immunosuppression, and the ethical aspects of the case are discussed in order to present the problems associated with fallopian tube transplantation.
Lymphoid tissue of the human fallopian tube consists of follicles, lymphoepithelium, and lymphatic and blood capillaries and is located consistently in the interstitial part of the human fallopian tube. Using an immunoelectronmicroscopic technique, we have elucidated the ultrastructure of the lymphoid tissue of the human fallopian tube and the fine distribution and ultrastructure of the lymphatics associated with the rabbit fallopian tube. Lymphatic capillaries arise in the lamina propria mucosa and the periphery of follicles, where they are sparsely distributed, run through the muscular layer, and form a dense network in the subserosa. Characteristic features of the ultrastructure are aggregations of smooth muscle cells, alternating areas of densely and sparsely distributed collagen fibers, and unmyelinated nerve fibers beneath the lymphatic endothelium. Immunoelectronmicroscopic analysis has demonstrated an obvious difference in the distribution of T- and B-lymphocytes in the lymphoid tissue of the human fallopian tube. Many T-lymphocytes are present in the follicles and epithelium, but B-lymphocytes are either absent or rarely found. T-lymphocytes sometimes infiltrate into the basal lamina of the epithelium lying in close contact with the follicles. We conclude that the lymphoid tissue is constantly located in the interstitial part of the human fallopian tube and that intraepithelial lymphocytes, mainly T-lymphocytes, migrate via the basal lamina of the epithelium from follicles. Lymphatic capillaries in the fallopian tube may be the main migratory route of intraepithelial lymphocytes. The intraepithelial lymphocytes and epithelial cells of the fallopian tube have attracted considerable interest as a result of immunological studies of the recognition of spermatozoal antigens and the fertilized ovum.(ABSTRACT TRUNCATED AT 250 WORDS)
Accessory fallopian tubes may be found during an evaluation for infertility. The true incidence is unknown but may be as high as 6%. A patient had an ectopic pregnancy in an accessory fallopian tube; its rupture led to emergency surgery. During the next six months, five infertility patients were noted to have accessory fallopian tubes among 100 surgical infertility patients and 398 surgical gynecology patients. The accessory tubes were removed using a microsurgical technique. Three of the five patients had had prior laparoscopy, and their operative reports stated that the pelvis was normal. We suggest a careful evaluation of the pelvis in each patient. If accessory tubes are noted during surgery, one should correct the anatomy to avoid potentially life-threatening situations.
The inflammatory effects of fallopian tube catheterization and selective injection of seven contrast agents (ethiodized oil, diatrizoate meglumine 52%, diatrizoate meglumine 66%, iothalamate meglumine 60%, iopamidol, ioxitol, and ioxaglate) were evaluated in 88 rabbits. The contrast agent used was randomly selected and selectively injected after unilateral catheterization; the contralateral side was used for control. Pathologic inspection of right and left uteri with attached fallopian tubes and ovaries was done without knowledge of side of catheterization or duration of time since catheterization. The degree and location of inflammation were noted. Inflammation disappeared by 4 days in five of seven contrast agents. Iothalamate meglumine 60% and iopamidol required 2 weeks for disappearance of inflammation. Essentially no inflammation was associated at any time with ioxaglate. These findings suggest that all of these contrast agents would be clinically acceptable for direct injection into the human fallopian tube.
Primary carcinoma of the fallopian tube is a rare condition and not easy to diagnose. On a smear taken from the vagina of a 73-year-old woman, cells consistent with adenocarcinoma were detected even though the patient was asymptomatic. The specimen from endometrial curettage was normal on microscopic examination. The patient was readmitted, 2 months after dilatation and curettage, with a right pleural effusion. Examination of the pleural fluid revealed adenocarcinomatous cells. Laparotomy disclosed a primary carcinoma (stage IV) of the left fallopian tube. Thiotepa (45 mg) was instilled into the chest cavity and medroxyprogesterone (100 mg tid) and melphalan (6 mg/d for 4 days over 6 weeks) were given. Although the life expectancy for stage IV primary carcinoma of the fallopian tube is less than 2 years this patient has no clinical evidence of disease 2 1/2 years after operation.