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At least 37 records · Page 2Linked to original sources
PubMed1978

Analysis of luteinizing hormone and follicle-stimulating hormone release kinetics during a dynamic secretory event, the postpartum preovulatory surge in the rat, based on quantitative changes in stored and circulating luteinizing hormone and follicle-stimulating hormone and metabolic clearance data for these hormones.

The original objective of this study was to use available distribution volume (V) and deca constant (k) estimates for rat LH and FSH to determine the amounts of these hormones synthesized and released during a dynamic secretory event, the postpartum preovulatory surge. The problem was approached by 1) determining the approximate rates and durations of pituitary LH and FSH depletion during the surge, and 2) comparing observed plasma LH and FSH patterns with patterns calculated on the assumptions a) that the rates and durations of LH and FSH release would have to equal or exceed the rates and durations of LH and FSH depletion, and b) that the V and k estimates reported by Bogdanove and Gay (Endocrinology 84: 1118, 1969) would be applicable in this situation. The observed surges proved to be 3- to 10-fold smaller than the calculated patterns, suggesting either that depletion exceded release or that inappropriate values of V and/or k had been used in the calculations. Subsequent reexaminations of LH clearance kinetics (Campbell et al., accompanying reports) provided larger estimates for both VLH and kLH. Recalculation of the data, using these new parameters, eliminated the apparent discrepancy between depletion and release. On the basis of these direct comparisons of stored and circulating LH, it seems that a "half-life" shorter than 30 min and a distribution volume greater than 3 ml/100 g must be used to model the effects of variations in LH release on circulating LH in the rat.

Animals↗
PubMedDate not supplied

Daily variations in urinary excretion of luteinizing hormone and follicle stimulating hormone in idiopathic isosexual precocity.

The 24-hour urinary excretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) was determined for 30 days in an 8.3-year-old girl with isosexual precocity and for 25 days in a normal 11.9-year-old girl. The pattern of daily variation in urinary LH and FSH excretion observed in the girl with sexual precocity was similar to that of the normal menstrual cycle. The LH and FSH midcycle peaks were 132.5 IU/24 hours and 26.3 IU/24 hours, respectively. Excluding the midcycle peak, the daily excretion of LH was 28.4 +/- 9.3 (SD) IU/24 hours, and the excretion of FSH was 8.9 +/- 1.9 (SD) IU/24 hours, values comparable to those of normal adult females. In contrast, the daily excretion of LH in the normal 11.9-year-old girl was 6.9 +/- 1.1 (SD) IU/24 hours and FSH excretion was 3.9 +/- 0.9 (SD) IU/24 hours. No LH or FSH surge was observed. The data are consistent with early maturation of the hypothalamic-pituitary-gonadal axis in idiopathic isosexual precocity.

Child↗
PubMed1976

Luteinizing hormone and follicle stimulating hormone and the response to luteinizing hormone releasing hormone in relation to sex and age.

Serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) before and after intravenous injection of luteinizing hormone releasing hormone (LHRH) were studied in 71 male and female subjects of various ages. Mean basal FSH and LH levels were not significantly different in the male groups, except that FSH was significantly higher in the very old subjects. Postmenopausal female subjects had much higher concentrations of both hormones than had premenopausal women. LH was higher in female subjects shortly after the menopause than in very old female subjects. The serum concentrations of both FSH and LH 30 min. after intravenous injection of 200 mug LHRH were not different from the 60 min. values. There was no significant difference in the response of LH in the male groups. The peak FSH concentration was higher in the very old male subjects. Postmenopausal women had a much higher peak concentration of both FSH and LH than had younger subjects. The increment of LH, but not of FSH, was larger in female subjects shortly after the menopause than in very old female subjects. In both sexes there was a significant correlation between the basal FSH/LH ratio and age. In younger male subjects there was a close positive correlation between basal LH and serum testosterone, in older male subjects this correlation was negative and significant.

Adult↗
PubMed1979

A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.

The effects of 2-Br-alpha-ergocryptine (2.5 mg/osM), clonidine (50 microgram, intramuscularly) and naloxone (0.4 mg, intramuscularly) as well as the interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PL) and thyroid-stimulating hormone (TSH) serum levels in normal man have been studied. 2-Br-alpha-ergocryptine and clonidine clearly reduce and naloxone tends to reduce PL serum levels. TSH levels are lowered by naloxone as well by clonidine plus naloxone. The results obtained point also to a possible different pattern of LH and FSH secretion after naloxone, that is after opiate receptor blockade. The clonidine effects on PL secretion are discussed in the frame of a possible adrenergic control of the release of this hormone.

Adult↗
PubMed1976

Serum luteinizing hormone, follicle-stimulating hormone, and testosterone responses to gonadotropin-releasing factor in males with varicoceles.

Five infertile males, ages 25 to 35, with oligospermia and varicocele had following gonadotropin-releasing hormone (LRF) infusion a rise of serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels which was not different from that of normal fertile males. The response of these hormones to LRF infusion was unaltered by spermatic vein ligation, but a significant elevation of the sperm count occurred. Thus, improvement in sperm count following spermatic vein ligation is not mediated via changes in peripheral gonadotropin or testosterone concentrations.

Adult↗
PubMed1975

Serum luteinizing hormone, follicle-stimulating hormone, prolactin and progesterone concentrations and follicular development in the pseudopregnant rat after unilateral ovariectomy.

Serum LH, FSH, prolactin and progesterone concentrations and follicular size were measured in rats during pseudopregnancy after unilateral ovariectomy (ULO) on day 1. This operation did not affect the duration of pseudopregnancy. Following pseudopregnancy compensatory ovulation occurred. After ULO progesterone concentrations remained low as compared with control values but the progesterone secretion per ovary was increased slightly. After ULO, LH concentrations were significantly increased on days 3 and 4 of pseudopregnancy. FSH concentrations were increased 5 h after the operation and again on day 4-7 of pseudopregnancy when compared with sham-operated control animals. During pseudopregnancy prolactin secretion increased each night. Increased prolactin levels were observed 18 and 36 h after ULO. The number of medium-sized follicles had increased 24 h after ULO. From the present study it is concluded that progesterone secretion by the corpora lutea can be increased to a limited degree by the increased release of gonadotrophins. Furthermore, it is concluded that a rapid increase in FSH concentrations after ULO is responsible for the initiation of the compensatory follicular growth.

Animals↗
PubMed1977

Serum levels of d-norgestrel, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone in women during and following ingestion of combination oral contraceptives containing dl-norgestrel.

Three formulations of dl-norgestrel were administered daily to groups of three women for five consecutive days. The serum levels of d-norgestrel were related to the dosage of dl-norgestrel ingested. Peak concentrations in the circulation of synthetic gestagen were attained a half hour to three hours after oral administration, followed by a rapid and sharp decline in levels until the next dose. Three women received 500 micrograms of dl-norgestrel and 50 micrograms of ethinyl estradiol for 21 days followed by six to seven days of no medication for two consecutive cycles. The gonadotropins remained suppressed for four to six days when therapy was discontinued. The daily concentrations of estradiol varied from less than 5 to 81 pg. per milliliter, and there was no difference in estrogen values during the nontreatment and treatment days. Due to the long half life of norgestrel, the one-week pill-free interval is not long enough for the complete recovery of the reproductive axis from the inhibition of oral contraceptives.

Adult↗
PubMed1979

Plasma melatonin, luteinizing hormone, follicle-stimulating hormone, prolactin, and corticoids in two patients with pinealoma.

Plasma melatonin, LH, FSH, PRL, and corticoids were measured in two patients with pineal tumors. Plasma melatonin was not detectable (less than 7 pg/ml) in either patient while gonadotropin and cortisol levels were within the normal range. One patient exhibited low PRL levels and the other patient, a prepubertal boy, had elevated levels. The clinical value of the measurement of melatonin as a potential marker for all pineal tumors must be questioned.

Adolescent↗