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Electro-encephalographic disturbances due to chronic toxin abuse in young people, with special reference to glue-sniffing.

A study was carried out in order to document any abnormalities in the electro-encephalogram (EEG) that might appear in young adolescents who have deliberately inhaled the range of volatile substances loosely referred to as 'glue'. The EEGs of a group of 'street children' being assisted in a Johannesburg shelter were examined. The records were analysed for any clinical abnormalities and also subjected to spectral analysis in order to examine the overall characteristics of frequency, power and spatial distribution. The EEGs clearly revealed that, although at the time of the examination the subjects were ostensibly abstinent, both clinical and normative evidence of continuing brain disturbance was present. It was concluded that glue sniffing is likely to have long term electrocerebral sequelae.

Adolescent↗

Glue-sniffing neuropathy.

Although industrial exposure to n-hexane is known to cause neuropathy, it is less well recognized that inhalation of n-hexane present in the vapors of some commercial contact cements is also neurotoxic to peripheral nerves. A young man with a long history of addictive glue-sniffing developed severe distal symmetrical polyneuropathy several months after switching to a cement containing n-hexane and gradually improved several months after switching to another cement containing no n-hexane. Fascicular biopsy of radial cutaneous nerve showed striking segmental distention of axons by neurofilamentous masses with secondary thinning of myelin sheath, paranodal myelin retraction, and widening velocities were correspondingly slow. We conclude that n-hexane used as a solvent in some contact cements may be neurotoxic when inhaled to excess and, further, that the neuropathy has characteristic electrophysiological and pathological features.

Acetates↗

Fetal syndromes and the charter: the Winnipeg glue-sniffing case.

The relationship between scientific knowledge and legal discourse is raised once again by a recent decision of the Supreme Court of Canada, a case involving a young Aboriginal woman who was pregnant and ordered by the court to remain in a drug treatment program at a health center until the baby was born. Her glue-sniffing habit was deemed dangerous to the normal development of the fetus. The Court held that her solvent-dependency did not justify the original court action, but both the Court and the various interveners disregarded the current state of our knowledge on the fetal syndromes. There is thus a continuing disconnect between the scientific understanding of fetal risk and the development of Constitutional law around women's reproductive rights. This paper reviews the case and follows it through the appellate process; we examine the research literature on fetal syndromes tracking the changes over time. Finally we comment on the interventions by the Winnipeg Child and Family Services, the Women's Health Rights Coalition, by The Canadian Civil Liberties Association, and both The Canadian Abortion Rights Action League and the Women's Legal Education and Action Fund.

Adult↗

Glue-sniffing as a cause of a positive radio-isotope brain scan.

Convulsions are a known complication of the acute intoxicant effects of solvent abuse. A radio-isotope brain scan done 9 months following status epilepticus secondary to toluene inhalation, in a previously normal school-boy, demonstrated several wedge-shaped areas of increased uptake, in both cerebral hemispheres, consistent with infarcts. It is worth remembering that a positive brain scan in a young person, with recent onset of epilepsy, may be due to glue-sniffing.

Adolescent↗

ACUTE AND CHRONIC EFFECTS OF GLUE SNIFFING.

Fifteen boys who were habitual sniffers of the kind of glue used for assembling model airplanes were investigated in regard to the acute and chronic toxicity of the substances in the glue. The acute effects of airplane glue were measured by serial psychometric testing in eight subjects and a transitory visual motor disturbance was found. In one case there was elevated spinal fluid pressure due to intoxication with the inhaled substance. No chronic renal, hematologic or hepatic changes were observed.

Adhesives↗

GLUE-SNIFFING. II.

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Adhesives↗

Glue sniffing causes heart block in mice.

In mice, the inhalation of airplane glue or toluene fumes slows the sinoatrial rate, prolongs the P-R interval, and sensitizes the heart to asphyxia-induced atrioventricular block. In humans who sniff glue or solvents, similar mechanisms may be a cause of sudden death.

Animals↗

Glue sniffing: a comparison study of sniffers and non-sniffers.

A study of 22 glue sniffers and 22 non-sniffers was carried out with individuals from the same reference group. The subjects were all street children living in supervised shelters. No statistically significant differences were found between the sniffers and non-sniffers on cognitive measures or biographical features (e.g. time spent at school, years on the street). When rated by shelter staff on a modified version of the Christiansen Rating Scale (1967) the sniffers were perceived to be significantly more disturbed in their relationships with others, however, methodological issues do not permit conclusive evidence of behavioural differences to be drawn. The authors conclude that the findings lend support for the view that the effects of volatile substance abuse on cognitive and personality functioning cannot be clearly demonstrated.

Adolescent↗

GLUE SNIFFING.

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Humans↗