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Results for “IRIDOCYCLITIS”

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At least 37 records · Page 2Linked to original sources

PubMed2000

Acute iridocyclitis in a patient with AIDS diagnosed as toxoplasmosis by PCR.

PURPOSE: To study the etiology of an acute iridocyclitis in a patient with AIDS using polymerase chain reaction (PCR) analysis of aqueous humor. METHODS: Case report describing a patient diagnosed with toxoplasmic retinochoroiditis in his left eye. He stopped his treatment after three weeks and subsequently developed an acute iridocyclitis without chorioretinitis in the fellow eye. Anterior chamber paracentesis was performed and aqueous humor was assayed by PCR. RESULTS: PCR of the aqueous humor showed positivity for Toxoplasma gondii. The iridocyclitis responded to topical dexamethasone and oral treatment with pyrimethamine and sulfadiazine. CONCLUSION: PCR is an effective method to diagnose toxoplasmic iridocyclitis in a patient with AIDS.

AIDS-Related Opportunistic Infections↗

PubMedDate not supplied

[An express-method for predicting fibrinous iridocyclitis in the early postoperative period in artiphakia].

The authors investigated the possibility of using the level of preoperative blood monocytosis as an express method for predicting fibrinous iridocyclitis in planned artiphakia. Extracapsular cataract extraction with intraocular correction (B. N. Alexeev's design) was carried out in 372 patients, 287 of these without non-insulin-dependent diabetes mellitus (NIDDM) (group 1) and 85 with NIDDM (group 2). The patients were divided into 3 subgroups depending on the absolute blood monocyte counts before operation: 1) up to 200 monocytes, 2) 200-400, and 3) more than 400. The incidence of fibrinous iridocyclitis was significantly higher (p < 0.01, 17-18-fold on average) in both subgroups 3 (more than 400 monocytes) in comparison with subgroups 1 (less than 200 monocytes), the treatment strategy being the same in all patients. In NIDDM group the total number of fibrinous iridocyclitis cases was 2 times higher in all 3 subgroups than in group 1. Hence, the level of preoperative blood monocytosis can be used as an express method for predicting fibrinous iridocyclitis in planned artiphakia choosing the treatment strategy during the immediate postoperative period, including that for patients with NIDDM.

Aged↗

PubMed1988

Nonsteroidal anti-inflammatory drug therapy in chronic childhood iridocyclitis.

The adjunctive use of nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of chronic iridocyclitis was evaluated in 14 patients, eight with juvenile rheumatoid arthritis and six with idiopathic iridocyclitis. In all patients, the activity of the iridocyclitis improved with the addition of NSAIDs to their treatment regimens, permitting reduction in the dose of corticosteroid drugs. These data suggest that NSAID therapy may have an adjunctive role in the treatment of chronic iridocyclitis in childhood.

Adolescent↗

PubMed1982

The significance of antinuclear antibodies in juvenile rheumatoid arthritis associated with chronic bilateral iridocyclitis.

Serum samples from 8 children with juvenile rheumatoid arthritis (JRA) and chronic bilateral iridocyclitis were significantly distinguished from 5 children with JRA and no eye symptoms by the presence of large immune complexes (IC) greater than 22S, IgM antinuclear antibodies (ANA), IgG granulocyte-specific (GS-) ANA, C3 fixing ANA, and IgM anti-IgG. One serum with and two sera without IC greater than 22S, all from patients with iridocyclitis, were fractionated by rate zonal ultracentrifugation. Each fraction relevant for the study was separately concentrated and reexamined. In one of the sera without IC greater than 22S this technique exposed the presence of IgA GS-ANA not detectable in the corresponding whole serum. IgG ANA were precipitated in an area with higher molecular weight than the one for IgG indicating the presence of aggregated IgG ANA. Fractionation of the serum with IC greater than 22S demonstrated IgM GS-ANA not present in whole serum. The results support previous suggestions that ANA may be involved in the pathogenesis of chronic iridocyclitis and may explain why ANA (in particular C3 fixing ANA) negative patients with JRA rarely develop chronic iridocyclitis.

Adolescent↗

PubMed1977

Clinical patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis.

In the present study we have reconfirmed an earlier observation of the association of iridocyclitis with limited joint involvement in children with JRA. Children who develop iridocyclitis are predominantly girls whose sera are positive for antinuclear antibodies. Iridocyclitis was found to be asymptomatic at onset. Only periodic slit lamp examinations will detect the majority of cases. Iridocyclitis began a median of 2 years after onset of arthritis. Although most episodes occurred within 7 years after onset of arthritis, the risk of this development may never be absent in these children, even after they enter adulthood. In the present study, 16% of the afflicted children experienced either unilateral or bilateral blindness.

Adolescent↗

PubMed1996

A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group.

OBJECTIVE: To assess the benefit of adding oral acyclovir to a regimen of topical prednisolone phosphate and trifluridine for the treatment of iridocyclitis caused by herpes simplex virus (HSV). METHODS: Patients with HSV iridocyclitis were enrolled in a multicenter controlled clinical trial supported by the National Eye Institute, Bethesda, Md, and randomly assigned to receive a 10-week course of either oral acyclovir, 400 mg, 5 times daily, or oral placebo in conjunction with regimens of topical trifluridine and a topical corticosteroid. Follow-up examinations were performed weekly during the 10-week treatment period, every 2 weeks for an additional 6 weeks, and at 26 weeks after enrollment in the trial. Treatment failure was defined as a persistence or worsening of ocular inflammation, withdrawal of medication because of toxicity, or a request by the patient to withdraw from the trial for any reason. The trial was stopped because of slow recruitment after only 50 of the originally planned 104 patients were enrolled in more than 4 years. RESULTS: A treatment failure occurred in 11 (50%) of the 22 patients in the acyclovir-treated group and in 19 (68%) of the 28 patients in the placebo group. Compared with the placebo group, the adjusted rate ratio for a treatment failure in the acyclovir-treated group during the 10-week treatment period was 0.43 (90% confidence interval, 0.18-1.02; P = .06, 1-tailed) and during the 16-week follow-up period (10-week treatment period plus 6-week observation period) was 0.60 (90% confidence interval, 0.29-1.25; P = .13, 1-tailed in a proportional hazards model). The treatment effect seemed slightly greater when only the patients with a persistence or worsening of ocular HSV disease were considered as treatment failures (ie, excludes terminations because of toxic effects of the drug and patients who requested to withdraw from the trial). By life-table analysis, similar results were obtained; the possible benefit of acyclovir became apparent after the first 3 weeks of follow-up. CONCLUSION: While the number of patients recruited in this trial was too small to achieve statistically conclusive results, the trend in the results suggests a benefit of oral acyclovir in the treatment of HSV iridocyclitis in patients receiving topical corticosteroids and trifluridine prophylaxis.

Acyclovir↗

PubMed1991

The epidemiologic association of Fuchs' heterochromic iridocyclitis and ocular toxoplasmosis.

Between January 1983 and July 1987, I examined 25 patients at the Department of Ophthalmology, West Virginia University, who had the anterior segment characteristics of Fuchs' heterochromic iridocyclitis. Of these patients, 16 had fundus lesions suggestive of ocular toxoplasmosis. Of these 16 patients, 13 had a positive serologic test for toxoplasmosis, two patients were not tested, and one patient had a negative test at 1:16. The remaining nine patients with Fuchs' heterochromic iridocyclitis had no fundus lesions suggestive of toxoplasmosis. A chart review of 792 consecutive patients at the Retinal Unit, West Virginia University, during a six-month period disclosed that 24 of 590 patients (4%) had chorioretinal scars suggestive of toxoplasmosis. I concluded from these data that in at least one subgroup of patients with Fuchs' heterochromic iridocyclitis there is a significant association with the chorioretinal scars of toxoplasmosis (P less than .01), and this is suggestive of a causal relationship.

Adult↗

PubMed2000

Tissue plasminogen activator to treat impending pupillary block glaucoma in patients with acute fibrinous HLA-B27 positive iridocyclitis.

PURPOSE: To report the use of intracameral tissue plasminogen activator to dissolve fibrinous membranes and break posterior synechiae in patients with acute HLA-B27-positive iridocyclitis with impending pupillary block. METHODS: Two patients with severe acute fibrinous iridocyclitis and seclusio pupillae were identified. Because of the concern of impending pupillary block, intracameral tissue plasminogen activator (12.5 microg in 0.1 ml, Activase; Genentech, Inc, South San Francisco, California) was injected with a 25-gauge needle through the corneal limbus. RESULTS: Both patients showed complete dissolution of fibrin with disruption of posterior synechiae. There were no adverse events after injection. Neither patient required further invasive intervention, and both fully recovered with medical management. CONCLUSIONS: Intracameral tissue plasminogen activator is a safe and effective agent for patients with severe acute iridocyclitis and pupillary seclusion. Patients with clinical signs suggestive of impending pupillary block glaucoma may be considered for tissue plasminogen activator injection to avoid the possible need for emergency surgical iridectomy and synechiolysis.

Acute Disease↗

PubMed1993

Intraocular lens implantation versus no intraocular lens implantation in patients with chronic iridocyclitis and pars planitis. A randomized prospective study.

PURPOSE: The authors studied the safety of intraocular lens (IOL) implantation in patients with uveitis. METHODS: The authors prospectively randomized 26 patients with chronic iridocyclitis (22 patients) or pars planitis (4 patients) to undergo IOL implantation or no IOL implantation at the time of cataract surgery. RESULTS: There was no statistical difference in visual acuity results at 1 year between the two groups. There was a trend toward better visual acuity in patients with chronic iridocyclitis without IOLs. Cocoon-like dense fibrous membranes enveloped the IOL in two patients. CONCLUSION: The authors conclude that IOLs are relatively safe in patients with chronic iridocyclitis but that only a much larger study could determine if the trend toward better visual acuity without an IOL was real.

Adult↗

PubMed1993

Cataract development and cataract surgery in patients with juvenile rheumatoid arthritis-associated iridocyclitis.

PURPOSE: The authors used an aggressive stepladder, steroid-sparing, therapeutic algorithm in the care of patients with iridocyclitis associated with juvenile rheumatoid arthritis (JRA) to preserve vision, limit cataract formation, and improve probability of successful visual rehabilitation when cataract surgery became necessary. METHODS: The authors treated 60 patients with JRA-associated iridocyclitis with topical and regional corticosteroids, systemic nonsteroidal anti-inflammatory drugs, systemic steroids, and systemic immunosuppressive chemotherapy to achieve total quiescence of intraocular inflammation. Cataract surgery (phacoemulsification extracapsular cataract extraction) combined with pars plana vitrectomy was performed on those eyes with cataract sufficient to limit visual acuity to 20/200 or less, after maintenance of complete freedom from inflammation for at least 3 months. The incidence of cataract development and the visual outcome of cataract surgery were analyzed in those patients for whom a minimum follow-up of 1 year was available. RESULTS: Eventually, 10 of the 60 patients required systemic immunosuppressive chemotherapy in the stepladder therapeutic approach to achieve complete abolition of all active inflammation. Of 72 phakic eyes without cataract, significant cataract developed in 13 (18%) while under our care. The average postoperative stable visual acuity in this group was 20/40. Sixteen eyes of 12 additional patients had visually significant cataract at the time of our first evaluation of them. The average postoperative stable visual acuity in this group of patients after cataract surgery was 20/40. CONCLUSIONS: Iridocyclitis associated with JRA is an insidiously blinding disease, with 12% of individuals affected by this problem eventually blinded by the inflammatory consequences to the eye. A therapeutic philosophy of complete intolerance for active inflammation and limited tolerance for chronic steroid use may offer the most realistic hope for the next step in progress to prevent blindness in this patient population. The results of this study suggest that such a therapeutic attitude results in diminished cataract prevalence and decreased prevalence of vision-limiting retinal pathology, with resultant improved visual outcome of the cataract surgery which is eventually needed in a small proportion of the patients.

Adolescent↗

PubMed1996

Intraocular lens implantation in eyes with Fuchs' heterochromic iridocyclitis.

PURPOSE: To evaluate the results of cataract surgery with intraocular lens (IOL) implantation in eyes with Fuchs' heterochromic iridocyclitis. SETTING: Saint-Victor Hospital, Amiens, France. METHODS: We reviewed the charts of 93 patients (94 eyes) with heterochromic iridocyclitis who had cataract extraction and IOL implantation by the same surgeon. In six patients, the IOL was placed in the anterior chamber; 9 received Binkhorst four-loop IOLs sutured at the 12 and 6 o'clock positions, and 79 received posterior chamber IOLs, 15 in the sulcus and 64 in the capsular bag. Follow-up was from 6 months to 10 years (mean 41 months). RESULTS: Precipitates on the IOL surface and white keratic precipitates were detected in 65.5% of eyes. Most eyes had minimal anterior segment activity. No severe uveitis was observed. The major problem, observed in 12.3% of the patients, was glaucoma. Best corrected postoperative visual acuity was 20/40 or better in 76.6% of eyes. CONCLUSION: Eyes with heterochromic iridocyclitis responded well to cataract extraction with IOL implantation. The restoration of satisfactory binocular vision justifies IOL implantation in patients with Fuchs' unilateral syndrome.

Adolescent↗

PubMed2000

Secondary glaucoma in patients with juvenile rheumatoid arthritis-associated iridocyclitis.

PURPOSE: The prevalence and management of glaucoma were evaluated in patients with juvenile rheumatoid arthritis (JRA)-associated iridocyclitis. METHODS: The records of 69 patients with JRA-associated iridocyclitis were reviewed. RESULTS: Twenty-nine (42%) of these patients had secondary glaucoma or ocular hypertension. Glaucoma was controlled with topical treatment in only 7 of the 41 affected eyes (17%); systemic carbonic anhydrase inhibitor therapy resulted in control of another 8 eyes. Surgery controlled all but one of the remainder. CONCLUSION: Glaucoma is a common complication of JRA-associated iridocyclitis. It results from prolonged, inadequately treated intraocular inflammation and in some instances, from steroid use. Medical and surgical therapy for the glaucoma associated with JRA-uveitis is challenging and incompletely effective. We suspect that a more aggressive approach to the treatment of JRA-associated uveitis, earlier in the course of the disease may reduce this vision robbing contribution to the process.

Adolescent↗

PubMed1998

Hyphema after peribulbar anesthesia for cataract surgery in Fuchs' heterochromic iridocyclitis.

PURPOSE: To describe an unusual ocular sign in one patient with Fuchs' heterochromic iridocyclitis at cataract surgery. METHODS: We describe a patient with Fuchs' heterochromic iridocyclitis and cataract who developed a 1 mm hyphema observed two minutes after peribulbar anesthesia for cataract surgery. RESULTS: The patient was found to have an equivalent of the Amsler-Verrey sign. It appeared after peribulbar anesthesia and before any instrument touched the globe. It did not interfere with surgery and disappeared completely by day 2. CONCLUSION: The appearance of a hyphema after peribulbar anesthesia in Fuchs' heterochromic iridocyclitis is an unusual sign that may have the same pathophysiology as the Amsler-Verrey sign.

Adult↗

PubMed1995

Fuchs' heterochromic iridocyclitis revisited.

Fuchs' heterochromic iridocyclitis is an unusual form of uveitis of unknown aetiology that continues to be poorly understood and underdiagnosed. We present the clinical features observed in 77 patients (89 eyes) seen in the Uveitis Clinic at Leicester Royal Infirmary over a 2-year period. The most common presenting symptom was visual deterioration (96.1%) rather than pain (18.2%). Only 50.6% were diagnosed as Fuchs' heterochromic iridocyclitis at presentation. At review, clinical heterochromic iridum was observed in 70.1% and 15.6% were bilateral. Lens opacities were seen in 73.0%, 40.4% (of the total) having undergone cataract surgery. Glaucoma was diagnosed in 15.7% at presentation and in 21.3% at review, by which time 9.0% (of the total) had required filtration surgery. It is important that Fuchs' heterochromic iridocyclitis is diagnosed correctly since, although many patients do not require active treatment, all should be screened at regular intervals for glaucoma.

Adolescent↗

PubMed1993

Elevated serum sialic acid in idiopathic acute iridocyclitis.

We measured the serum levels of sialic acid in 12 patients with idiopathic acute iridocyclitis and 18 normal controls. Sialic acid levels were significantly elevated in the patients with idiopathic acute iridocyclitis. Since animal studies have shown that intraocular inflammation alone cannot elevate serum level of sialic acid, the result of our study suggest that idiopathic acute iridocyclitis may be a multiorgan disease with systemic effects.

Acute Disease↗

PubMed1993

Iris crystals in chronic iridocyclitis.

Iris crystals in three patients with idiopathic iridocyclitis, Fuchs' heterochromic iridocyclitis, and iridocyclitis associated with systemic pseudolymphoma are described. Two patients had iris crystals in one eye, and the other patient had bilateral involvement. The number of iris crystals in each eye ranged from one to multiple crystals. Iris crystals were minute and refractile and glistened with light; they have previously been reported to be Russell bodies and to be associated with hypergammaglobulinaemia. However, two of the patients, who underwent serum protein electrophoresis, did not demonstrate hypergammaglobulinaemia.

Adult↗

PubMed2000

[Phacoemulsification in eyes with Fuchs' heterochromic iridocyclitis].

PURPOSE: To evaluate the effect and safety of phacoemulsification with intraocular lens (IOL) implantation in eyes with Fuchs' heterochromic iridocyclitis. METHODS: We reviewed the 13 patients (14 eyes) with heterochromic iridocyclitis who had phacoemulsification and IOL implantation. Intraoperative and postoperative complication was observed. RESULTS: Intraoperative complication included miosis and hemorrhage in anterior chamber. Postoperative complication were glaucoma and hyphemia. Best corrected postoperative visual acuity was 1.0 or better in 65% of eyes. CONCLUSION: Eyes with heterochromic iridocyclitis tolerated well to the phacoemulsification with IOL implantation.

Adult↗

PubMed2003

[Dental foci as important factors in the etiology of iridocyclitis].

Dentodenic focuses participate in huge percentage in etiology of iridocyclitis. Beside other causes which have this eye illness like complication, such as sinusitis, diabetes mellitus, rheumatic disease, most mentioned pathological professes are these. In ophthalmology cabinet in Fojnica, during year 2002, 127 patients with dyagnosis of iridocyclitis were examined and treated, aged 9-71 both sex. After sitting of diagnosis of iridocyclitis, we want further insetting of etiological diagnosis. After complete diagnostic searches dentogenic focus was cause for this eye illness at 49 patients. After stomatological therapies such as extraction of tooth and/or conservative treatment, after short exacerbation of symptoms, immediate improvement was indicated and normalization of eye was visible, of course with adequate ophthalmological therapy.

Adolescent↗