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At least 37 records · Page 2Linked to original sources
PubMed1967

Retrograde amnesia produced by intraperitoneal injection of physostigmine.

Intraperitoneal injection of physostigmine in rats produced a retrograde amnesia of a trained task of escaping shock. This amnesic effect was a U-shaped function of the length of the interval between initial training and injection. In all cases, retraining Occurred 30 minutes after injection. A substantial effect was produced by physostigmine if its application was made 30 minutes after training; there was no effect if application and tests were made 1, 2, or 3 days after the original training. When the substance was injected and the rats were retrained 5, 7, or 14 days after the original training, a substantial effect again appeared. These results are similar to those reported in experiments in which another anticholinesterase, diisopropyl fluorophosphate, was applied intracerebrally. The data demonstrate a similar pattern of change of the amnesia with time, and they substantiate the view that neither the place of application nor the brain lesions caused the reported amnesia.

Amnesia↗
PubMed1991

[Inhibition of the high-threshold calcium current in hippocampal neurons of rats subjected to intraperitoneal injection of phenylalanine].

Effect of intraperitoneal injection of phenylalanine on the calcium current of hippocampal neurons of rats has been studied by the voltage clamp method of the whole-cell recordings. Calcium currents in hippocampal neurons of control animals after 5-7 days in culture can be separated into two components: low and high voltage-activated ones. The value of high voltage-activated calcium current was 69 +/- 13% at Vt = -10 mV from total calcium inward current in these neurons. High voltage-activated Ica in neurons of phenylalaninemic rats was significantly depressed and its value was 32 +/- 14%, the Vt value being the same. Low voltage-activated calcium current was resistant to intraperitoneal injection of L-phenylalanine.

Animals↗
PubMed1986

Stimulation of hepatic polyamine metabolism following intraperitoneal injection of some dietary oils.

Intraperitoneal injection of partially hydrogenated marine oil into rats is shown to cause marked stimulation of hepatic polyamine metabolism, as characterized by increased activity of ornithine decarboxylase (EC 4.1.1.17), and corresponding increase in tissue levels of putrescine. A maximal effect was observed about 5 hours after injection. An effect on the hepatic activity of S-adenosyl-methionine decarboxylase (EC 4.1.1.50) was also observed. Of the various dietary oils examined only partially hydrogenated marine oil gave significant stimulation of polyamine metabolism. A single oral dose of partially hydrogenated marine oil gave a small increase in hepatic ornithine decarboxylase activity.

Animals↗
PubMed1976

Cross-tolerance between inhaled cannabis and intraperitoneal injections of delta9-THC.

Male and female rats were exposed to Cannabis smoke or placebo once every second day for 32 days. Following these 16 trials all animals were injected once intraperitoneally with 4 mg/kg THC. After every third inhalation trial and after the injection the rats were placed on a movement sensor for 3 min. Cannabis smoke significantly reduced activity, relative to baseline scores, during the first 10 inhalation trials but by the thirteenth exposure, tolerance was evident. When the animals were injected with THC, the male rats who had been exposed to Cannabis smoke significantly increased their activity whereas the females did not alter their activity relative to the last inhalation trial. In contrast rats of both sexes that had been exposed to placebo smoke significantly decreased their activity following the injection. This intermodal cross-tolerance is discussed in terms of the role of conditioning in the development of tolerance.

Cannabis↗
PubMed1979

Acrylic microspheres in vivo. I. Distribution and elimination of polyacrylamide microparticles after intravenous and intraperitoneal injection in mouse and rat.

Microspheres of 14C-labeled highly cross-linked polyacrylamide (mean diameter 0.25-0.30 micron) have been prepared by emulsion polymerization. The label was introduced in the polymer via the cross-linking monomer. N,N'-[14C]methylenebisacrylamide. The microparticles were used to follow qualitatively and quantitatively the distribution and the fate of polyacrylamide in mouse and rat after i.v. and i.p. injection. The polyacrylamide particles are rapidly cleared from the circulation (t 1/2 in rat approximately 40 min) by macrophages of the reticuloendothelial system. They are mainly (about 80%) found in the liver and spleen both after i.v. and i.p. injection (4.1 mg given totally to mice weighing 20-25 g). They can also be detected early (1 hr after i.v. injection) in the bone marrow, and particle aggregates are also initially found in the lungs, although no respiratory problems were noted. After about 16 weeks, the radioactivity rapidly decreases in the liver and spleen, with t 1/2 10 to 14 weeks and 15 to 24 weeks, respectively, depending on the route of administration. Radioactivity in the gut and gut walls detected 2 months after injection suggests that the polyacrylamide is slowly metabolized. No toxic effects-apart from transient hepatospleenomegaly-were detected in mice 45 weeks after they were given a total of 9.8 mg of polyacrylamide.

Acrylamides↗
PubMed1985

[Binding of 3H-spiperone in the mouse brain after intraperitoneal injection].

In experiments on mice 3H-spiperone binding after intraperitoneal injection was studied. The binding of 3H-spiperone was saturable in the frontal cortex and subcortical structures, whereas in the cerebellum, the amount of radioactivity increased in a linear manner and was referred to as nonspecific binding. The neuroleptics haloperidol, chlorpromazine and sulpiride given 0.5 h before 3H-spiperone displaced 3H-spiperone in the subcortical structures in a dose-related manner. Although the level of the specific 3H-spiperone binding after intraperitoneal injection was lower than after intravenous injection, the intraperitoneal method is simpler, well reproduced and given results comparable with the intravenous method.

Animals↗
PubMed1981

Enzymatic changes in rat thymus after intraperitoneal injections of adrenocorticotrophic hormone and corticosterone.

Intraperitoneal injection in adult male rats with adrenocorticotrophic hormone (ACTH) (0.6 mU daily for 3 days) brought about a marked decrease in the activities of four thymic enzymes studied: glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, isocitric dehydrogenase, malic dehydrogenase. A prominent rise in the levels of these enzymes occurred when ACTH was replaced by corticosterone (1 mg injected daily for 3 days). In adrenalectomized rats, the results were similar to those observed in intact animals. The significance of an increase in transaminase activities after corticosterone treatment, relating to an increase in citric cycle enzymes is discussed. On the other hand, it was suggested that ACTH exerts an extra adrenal effect on the thymus.

Adrenalectomy↗
PubMed1981

Unit activity changes elicited in amygdala and neocortex of anaesthetized rats by intraperitoneal injection of lithium chloride.

Intraperitoneal injection of 0.15 M LiCl (2% body weight) to anaesthetized rats elicited, after a 6 min latency, discharge of about 50% units i basolateral amygdala (n = 27). The activation lasted for 15 min on the average. Cortical neurones were not affected by the LiCl injection. It is suggested that the amygdalar reaction to LiCl administration may account for the association of the gustatory trace with the visceral signals of poisoning which mediates acquisition of conditioned taste aversion under anaesthesia.

Amygdala↗
PubMed1988

Modified lymphocyte response to mitogens after intraperitoneal injection of glycopeptidolipid antigens from Mycobacterium avium complex.

Intraperitoneal injection of glycopeptidolipid (GPL) antigens from Mycobacterium avium complex serovar 4 resulted in the decreased ability of murine splenic lymphocytes to respond to nonspecific-mitogen-induced blastogenesis when exposed to concanavalin A, phytohemagglutinin, and lipopolysaccharide. Adherent cell depletion and cell mixing experiments with T lymphocytes indicated that macrophages were not a major contributor to the immunosuppression observed in this study. Enumeration of splenic lymphocytes by means of flow-cytometry with fluorescein isothiocyanate-conjugated monoclonal antibodies demonstrated that intraperitoneal injection of GPL antigens resulted in a significant decrease in Thy-1+ and Lyt-1+ cells but no change in the numbers of Lyt-2+ cells. Treatment with GPL antigens in vitro affected the ability of splenic mononuclear cells to respond optimally for concanavalin A-induced blastogenesis at 40 micrograms of GPL per 4 X 10(5) cells per 0.2 ml and lipopolysaccharide-induced blastogenesis at concentrations ranging from 5 to 40 micrograms of GPL per 4 X 10(5) cells per 0.2 ml. However, in vitro treatment with GPL antigens did not affect phytohemagglutinin-induced blastogenesis at concentrations ranging from 5 to 40 micrograms of GPL per 4 X 10(5) cells per 0.2 ml. These findings suggest that GPL antigens or their metabolites affect lymphocyte function and may be important cofactors in the overall pathogenesis of M. avium complex infections.

Animals↗