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At least 37 records · Page 2Linked to original sources
PubMed1983

[Clinical aspects and radiosensitivity of bone metastases in kidney neoplasms].

Among 130 patients with disseminated renal cell carcinomas 29 cases with skeletal involvement have been analyzed. Skeletal metastasis is associated with oligotopic and frequently extraosseous growth of large metastases. Extraosseous growth was noted in 85% of the cases. This phenomenon was less frequent in cases with combined metastatic involvement of bone and visceral organs. Skeletal metastases were shown to be fairly resistant to radiation therapy in terms of objective remission although symptomatic pain relief could usually be achieved. Interestingly, in cases with osseous involvement only the survival was significantly longer compared to visceral and mixed forms of metastatic disease. Radiotherapeutic consequences resulting from this biological behaviour of osseous metastases are discussed.

Adult↗
PubMed1994

A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea.

Embryonal kidney cell tumors develop in rats given the alkylating agent N-nitroso-N'-methylurea as neonates. These tumors resemble the childhood Wilms tumors in their histopathology. Deletions and mutations in the Wilms tumor suppressor gene, WT1, are present in up to 6% of childhood nephroblastomas. To investigate the role of WT1 in rat kidney tumorigenesis, we studied the genetic alterations in WT1 and its target genes. Point mutations were found in WT1 cDNA in 7 of 18 kidney tumors. Mesenchymal tumors contained G-->A transition mutations in codons 128, 364, and 372, typical of the methylating action of N-nitroso-N'-methylurea on DNA. Each of the four nephroblastomas contained the same T-->A mutation at codon 111 of WT1, reflective of transversion mutagenesis by N-nitroso-N'-methylurea in vivo. Like Wilms tumors, mRNA levels of WT1, IGF2, Pax-2, and MK genes were higher than newborn kidney in the majority of the tumors. The histopathology of the rat kidney tumors and the genetic alterations are reminiscent of those observed in Wilms tumors, establishing this as a relevant model system for the human disease.

Animals↗
PubMed1996

[Massive hemorrhage from a gastric neuroma associated with a kidney neoplasm].

A case of a gastric neuroma and kidney cancer were reported. The first symptoms of the disease was gastric haemorrhage. Urgent endoscopy showed submucous tumor of the gastric wall. The physical examination showed a presence of a tumor of the rib, proved to be secondary deposit from kidney carcinoma which had been found on abdominal ultrasound examination. Submucous excision of the followed by left nephrectomy was performed. At present an intensive x-ray therapy of rib tumor is continued because of patient's disagreement for rib resection.

Adenocarcinoma, Clear Cell↗
PubMed1956

[Kidney neoplasms].

Explore the source record for details and available documents.

Kidney Neoplasms↗
PubMed1979

Kidney neoplasms.

The author reviews the diagnosis and treatment of carcinoma of the kidney. Surgery remains the most effective therapy. The management of metastatic disease is discussed.

Adenocarcinoma↗
PubMed1998

[Blood reinfusion during nephrectomy in patients with kidney neoplasm'].

Reinfusion of autologous blood in 22 patients with cancer of the kidney was used during nephrectomy. Intraoperative blood loss made up 1000-4000 ml (20-80% VCB). 800-3600 ml of blood was collected from the operation wound and reinfused. In spite of massive blood loss, 20 patients recovered. Lethal outcomes (2 patients) were not caused by blood reinfusion. In 19 patients of control group with renal cancer massive blood loss was compensated by preserved donor blood transfusion. It is shown that reinfusion of autologous blood promotes more stable hemodynamics during the operation, reduces the quantity of postoperative complications and lethal outcomes, provides qucker restoration of morphologic structure of the blood and results in less substantial changes in filtration of a single kidney. There were no statistically significant differences in 5-year survival rate of patients in the study (40.9%) and control (42.1%) groups, nor in the frequency of hematogenous metastasizing of cancer. Because blood reinfusion does not increase the risk of hematogenous metastases of cancer, it is not contraindicated in massive blood loss during nephrectomy in patients with renal cancer.

Adenocarcinoma↗