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PubMed1987

[Extent and intensity of endoparasitic infection in the hedgehog].

601 faecal samples, 232 gastrointestinal tracts and 209 lungs from hedgehogs (Erinaceus europeaus L.) have been investigated parasitologically in the winter time of the years from 1980/81 to 1985/86. Developmental stages of parasites were discovered in 517 (= 86.0%) of the investigated faecal samples. 180 (= 86.0%) lungs harboured the worms of Crenosma striatum and/or Capillaria aerophilia. A total of 216 (= 93.1%) of the 232 investigated gastrointestinal tracts were parasitized with Capillaria spp., Brachylaemus erinacei, and Coccidia, respectively.

Animals↗
PubMed1997

Induction of protective immunity and modulation of granulomatous hypersensitivity in mice using PIII, an anionic fraction of Schistosoma mansoni adult worm.

This study was performed in order to define Schistosoma mansoni antigens that are able to function as modulator agents in the granulomatous hypersensitivity to parasite eggs in BALB/c and C57BL/6 mice. A fraction of S. mansoni, designated PIII, derived from adult worm antigen preparation (SWAP) was obtained using anion-exchange chromatography on an FPLC system. Immunization of mice with PIII in the presence of Corynebacterium parvum and Al(OH)3 as adjuvant induced an immune response in this animals as determined by ELISA and spleen cell proliferation assays against S. mansoni antigens SEA, SWAP and PIII. In addition, PIII caused a significant degree of protection against a challenge infection in immunized mice as observed by the decrease on worm burden recovered from the portal system. We also showed that PIII profoundly inhibited the vigorous anamnestic granulomatous response to eggs in the liver and lungs. This suppression correlated with a significant decrease in granuloma size. From these results we conclude that the PIII preparation contains antigens that can mediate protective anti-parasite immunity and downregulate granulomatous hypersensitivity to S. mansoni eggs.

Adjuvants, Immunologic↗
PubMed1996

Therapeutic effect of reference antileishmanial agents in murine visceral leishmaniasis due to Leishmania infantum.

A sensitive, culture-based, microtitration technique has recently been developed for determining parasite burdens in organs recovered from Balb/c mice infected with Leishmania infantum. In the present study, this technique was used to examine the efficacy of three, first-line, antileishmanial agents in reducing parasite burdens and eradicating parasites from target organs in mice. Treatment with meglumine antimoniate (50 mg SbV/kg.day) significantly reduced the parasite burdens in the livers and lungs (by about 10-fold and > 100-fold, respectively) but not those in the spleens. Although use of a higher dose of meglumine antimoniate (200 mg SbV/kg.day) resulted in an even more dramatic reduction in the parasite burdens in the livers, it had no significant effect on the burdens in the spleens. Treatment with amphotericin B (0.8 mg/kg every other day) resulted in significant reductions in the parasite burdens in the livers, spleens and lungs of infected mice. Although low doses of aminosidine (20 mg/kg.day) had no effect, high doses (200 mg/kg.day) resulted in undetectable parasite burdens in the livers, for at least 100 days post-treatment, and marked reductions in burdens in the spleens. These results are consistent with previous data from studies using animal models of visceral leishmaniasis. Thanks to the sensitivity of the technique, culture microtitration revealed that none of the drug schedules achieved the elimination of all parasites in all target organs. The murine model used mimics some important features of HIV/Leishmania infantum co-infections in humans.

Amphotericin B↗
PubMed1994

[Possibilities of contagion of gastrointestinal and lung nematode infections of fallow deer for cattle, sheep and goats raised in the same fenced area as fallow deer].

Cattle as well as sheep and goats may be infected with parasitic nematodes of fallow deer under natural conditions, but heavy infections do not occur. Most nematode species were recorded in goats, cattle harboured the fewest number of species. The specific abomasal parasites of fallow deer (Spiculopteragia asymmetrica, Apteragia quadrispiculata, Skrjabinagia ryjikovi, Ostertagia drozdzi) were only seen in goats in greater number while both cattle and sheep were only poor susceptible. Capillaria bovis was observed in goats and sheep, cattle and sheep harboured Cooperia pectinata and Nematodirus roscidus. Oesophagostomum venulosum was recorded in cattle, sheep and goats. Oesophagostomum sikae was recovered only from fallow deer. Dictyocaulus eckerti was seen in fallow deer and in one cattle.

Animals↗
PubMed2004

Therapeutic and persistent efficacy of moxidectin 1% nonaqueous injectable formulation against natural and experimentally induced lung and gastrointestinal nematodes in cattle.

Four controlled trials were conducted to evaluate the therapeutic and persistent efficacy of a new moxidectin formulation (moxidectin 1% nonaqueous injectable) against nematode parasites in cattle. This injectable moxidectin formulation, given as a single subcutaneous injection at a dose rate of 0.02 ml/kg BW to provide 0.2 mg moxidectin/kg BW, was highly efficacious (>90-100%) against larval and/or adult stages of many species of nematodes in cattle including, Dictyocaulus viviparus, Ostertagia spp., Trichostrongylus axei, Haemonchus placei, Trichostrongylus colubriformis, Cooperia spp., Nematodirus helvetianus, Strongyloides papillosus, Oesophagostomum radiatum and Trichuris spp. This formulation had persistent efficacy of >90% against D. viviparus for at least 6 weeks post-treatment, H. placei and Oe. radiatum for 5 weeks post-treatment, and Ostertagia spp. and T. axei for 2 weeks post-treatment.

Animals↗
PubMed1988

Efficacy of flubendazole against gastrointestinal and lung nematodes in pigs.

Three trials were carried out on landrace pigs of various ages to assess the anthelmintic efficacy of flubendazole. The pigs were either artificially infected with Metastrongylus apri or naturally or artificially infected with the gastrointestinal nematodes Ascaris suum, Oesophagostomum dentatum or Hyostrongylus rubidus. For mass medication of young pigs and fatteners a dose regimen of 30 ppm flubendazole in the feed for 10 consecutive days was 100 per cent effective against the four nematode species. For individual medication a single dose of 5 mg/kg bodyweight administered in a small amount of feed was also 100 per cent effective. No side effects were observed.

Animals↗
PubMed1992

Anthelmintic activity of paraherquamide in calves.

Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the adult stages of nine common gastrointestinal and lung nematodes of calves at single, oral dosages of 0.5, 1.0, 2.0 or 4.0 mg kg-1. At dosages 1.0-4.0 mg kg-1 there was 95% or more removal of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Nematodirus helvetianus, Oesophagostomum radiatum, and Dictyocaulus viviparus. Cooperia punctata, the dosage-limiting species, was virtually unaffected by any dosage except the highest, which produced an efficacy of 89%. The 0.5 mg kg-1 dosage was 95% or more efficacious against H. placei, O. ostertagi, C. oncophora, and D. viviparus, but weaknesses were evident against the other five species. No adverse reaction was observe in any calf.

Animals↗
PubMedDate not supplied

A contribution to the study of acute schistosomiasis (an experimental trial).

In an attempt to establish an experimental model of acute schistosomiasis, sequential histological changes were investigated in the skin, lung, liver and spleen of mice infected with 30 or 100 cercariae of Schistosoma mansoni according to four sets of experiments: single infection, repeated infections, unisexual infection and infection in mice born from infected mothers. Animals were killed every other day from exposure up to 50 days after infection. Only mild, isolated, focal inflammatory changes were found before the appearance of mature eggs in the liver, even when repeated infections were made. Severe changes of reactive hepatitis and splenitis appeared suddenly when the first mature eggs were deposited, around the 37th to 42nd day after infection. The mature eggs induced lytic and coagulative necrosis of hepatocytes around them which was soon followed by dense infiltration of eosinophils. So, mature egg-induced lesions appeared as the major factors in the pathogenesis of acute schistosomiasis in mice. Mice born from infected mothers were apparently able to rapidly modulate the egg-lesions, forming early fibrotic granulomas. The murine model of acute schistosomiasis appeared adequate for the study of pathology and pathogenesis of acute schistosomiasis.

Acute Disease↗
PubMed1980

Disseminated strongyloidiasis. Diagnosis made by sputum examination.

Two immune-compromised patients had pulmonary and intestinal infection due to Strongyloides stercoralis. Diagnosis was facilitated in both cases when the parasites were found in the sputum. Treatment with thiabendazole appeared to eradicate the infection, but repeated follow-up examinations are needed because of the likelihood of relapse.

Feces↗
PubMed1992

Sudden death due to disseminated porocephalosis--a case history.

An 18-year-old Nigerian girl died suddenly and unexpectedly from disseminated porocephalosis. The patient was hospitalised complaining of fever, dizziness, weakness and jaundice. Clinical examination revealed a restless, confused and hypotensive patient. She died within two hours of admission. Autopsy revealed disseminated Porocephalus armilatus infestation involving the thoracic and abdominal linings and their internal organs. The relationship between the disseminated parasitic involvement and the death of this girl is discussed.

Animals↗
PubMed1985

Schistosoma haematobium: the pathology of experimental infection.

The pathologic changes in experimental animals infected with Schistosoma haematobium are reviewed and compared to the pathology in infected humans. The clinically important lesions in persons infected with S. haematobium are generally confined to the urogenital system. In experimental animals, functionally important lesions of the urogenital system are the exception but do occur in a significant proportion of infected primates. The acute lesions of the urinary tract in primates are similar to those in infected persons. Chronic lesions characterized by the extensive submucosal accumulation of calcified eggs are common in infected humans but uncommon in S. haematobium-infected animals.

Animals↗
PubMed1991

Four years of cryptosporidiosis at GaRankuwa Hospital.

Cryptosporidiosis was first recognised at GaRankuwa Hospital, a reference teaching hospital for mainly black patients near Pretoria, South Africa, in October 1985. Since then 289/6870 specimens (4.21%) submitted to the routine stool laboratory have been found to contain Cryptosporidium parvum oocysts. Seasonal peaks were seen in late summer (January, February, March) and minimum case numbers were recorded during late winter (August, September). The disease was predominantly one of early childhood, with the majority of patients being under 3 years of age. Only six positive stools came from patients older than 12 years. Cryptosporidiosis has replaced giardiasis as the most commonly detected gastrointestinal parasitic infection of patients in this hospital. Oocysts were also found in the sputum of an 84-year-old male patient with a persistent productive cough.

Adolescent↗
PubMed1987

Relationship between cytologic changes in bronchoalveolar lavage fluid and weight gain in calves with gastrointestinal nematodes and lungworms.

Two of three groups of 10 calves each were infected with either 100,000 infective larvae (L3) of Ostertagia spp. and 100,000 L3 of Cooperia spp. or with 4000 L3 of Dictyocaulus viviparus, respectively, at the age of 14 weeks. The third group was not infected. After treatment with an anthelminthic five calves from each group were challenged with either 100,000 L3 of Ostertagia spp. and 100,000 L3 of Cooperia spp. or 4000 L3 of Dictyocaulus at the age of 20 weeks. The calves were 25 weeks old when slaughtered. Total and differential cell counts were determined in bronchoalveolar lavage fluid and showed that neutrophils were the most frequent and eosinophils the least frequent cell present. There was a significant negative relationship between eosinophil levels and weight gain of the calves.

Analysis of Variance↗