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PubMed1977

[Limulus test in diagnosis of acute meningitis (author's transl)].

We tried to evaluate the utility of the Limulus Test in the diagnosis of acute meningitis. The study was made in 60 patients divided in three groups: Group A, formed by 37 children affected by purulent meningitis of known etiology; Group B, formed by 10 children affected by purulent meningitis of unknown etiology; Group C, formed by 13 children with viral meningitis. The results were compared with a control group (Group D), of 10 healthy children. The results correlated with the etiology, the cuantitative count of germs/ml. in C.S.F. and the clinical evolution. The results indicated that the Test is a rapid, simple and useful tool for the detection of endotoxin in the C.S.F. of purulent meningitis caused by Gram negative germs.

Acute Disease↗
PubMed1976

[Contribution of the "limulus test" to the diagnosis of endotoxemias and meningitis due to gram negative bacteria].

The "limulus test" may be used to detect the endotoxins of Gram negative organisms. Applied to the cerebrospinal fluid (79 specimens from 64 patients) it proved itself to be a very important contribution to the differential diagnosis of purulent meningitis (95% positive results, no false positives). However it can be used on the plasma only in patients with shock of suspected endotoxic origin.

Adult↗
PubMed1975

Detection of endotoxins with the Limulus test in burned and unburned mice infected with different species of gram-negative bacteria.

The Limulus test detected endotoxins in the plasma of burned and unburned mice infected with different species of gram-negative bacteria produced different amounts of endotoxin in the plasma of infected mice. Plasma from mice given lethal infections showed very high concentrations of endotoxin. Low concentrations of endotoxin in the plasma were tolerated by mice but high concentrations were invariably fatal. A polyvalent pseudomonas vaccine reduced endotoxin in the plasma of mice given lethal infections of Pseudomonas aeruginosa.

Administration, Topical↗
PubMed1976

Clinical experience in detecting endotoxemia with the limulus test in typhoid fever and other Salmonella infections.

Semiquantitative estimates of circulating endotoxin were performed by the limulus test in patients suffering from typhoid fever and other salmonelloses. The test was positive in a large number of cases. However, no clearcut correlation was found between existence of endotoxemia, as such, and pyrexia. A correlation with recent bacteremia was found for highest levels of endotoxin activity. In minor salmonelloses a striking prevalence of positive cases was observed in the age group under one year. These findings were discussed in relation to the diagnostic and pathogenetic facets of the problem.

Adolescent↗
PubMed1978

[Limulus test].

Explore the source record for details and available documents.

Humans↗
PubMedDate not supplied

[Verification of contamination with bacterial endotoxins in blood derivatives used in coagulative disorders: observations with the Limulus test].

The AA. expose the results of an investigation for an in vitro endotoxin assay by Limulus lysate test in blood products employed in coagulative area. The Limulus assay has been shown to be a simple, rapid, accurate and sensitive method of detecting bacterial endotoxin or endotoxin-like material in these biological products.

Biological Products↗
PubMed1975

Lack of clinical usefulness of the limulus test in the diagnosis of endotoxemia.

Studies of the clinical value of the limulus amebocyte lysate test for the detection of endotoxemia are inconsistent. In an attempt to define the value of this test, a total of 237 plasma samples from 111 patients were tested for endotoxin with seven different lysate preparations. A total of 48 plasma samples yielded a positive test with one or more of the seven preparations. Two of eight samples positive with all seven preparations were from ambulatory patients. A significant positive correlation of the test with bacteremia, neutrophilia and elevated serum alkaline phosphatase was found. Only three of the 48 positive tests occurred by four hours of incubation, and only 12 were associated with positive blood cultures (eight contained gram-negative bacteria). The test now available has no clinical usefulness in the detection of endotoxemia or gram-negative septicemia.

Adolescent↗
PubMedDate not supplied

Limulus test, parenteral drugs and biological products: an approach.

The Authors report the results concerning the control of presence of bacterial endotoxins in parenteral drugs, blood products and immunological materials, by means of Limulus amebocyte lysate test. All the data suggest that Limulus assay is a simple, rapid, specific and sensitive test for endotoxin detection, mostly when it is correctly performed.

Antibodies, Bacterial↗
PubMed1976

Limulus test, parenteral drugs and biological products: an approach.

The Authors report the results concerning the control of the presence of bacterial endotoxins in parenteral drugs, blood products and immunological reagents and drugs, by means of Limulus amebocyte lysate test. All the data suggest that Limulus assay is a simple, rapid, sensitive test, mostly when it is correctly performed.

Antibody Formation↗