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At least 37 records · Page 2Linked to original sources
PubMed1996

[Mouth neoplasms: a review].

An overview is presented of the epidemiology, etiology, clinical and diagnostic aspects, treatment and possible prevention of oral cancer. The dental profession may play a key role in the early detection of cancer and possible precursor lesions such as leukoplakia and erythroplakia. Since the use of tobacco is considered to be the main etiologic factor in oral cancer the dentist can play an active role in its primary prevention by informing his patients about the adverse effect of tobacco use and by encouraging patients to enter tobacco cessation programs.

Dentistry↗
PubMed1980

[Quantitative shifting of intra and peritumoral cell populations after intratumoral BCG-cell-wall therapy in squamous epithelial mouth neoplasms].

A qualitative histologic examination of squamous cell carcinoma of the buccal cavity was made before and after the injection of BCG cell walls directly into the tumor. The density of the inflammatory infiltrate in and at the tumor site differed significantly. The distribution pattern of the cells involved in the infiltrate showed an increased number of lymphocytes and histiocytes. Lymphocytes, the largest cell group represented, were more frequently demonstrated in the tumor than outside it. The injection of BCG cell walls directly into the tumor primarily causes a shift in the total number of cells and only secondarily an alteration in the distribution pattern of the cells involved in the infiltrate.

Administration, Topical↗
PubMed1978

[Surgical and radiotherapeutic possibilities of treatment of mouth neoplasms].

The basic concept of the treatment of cancer of the oral cavity has not essentially changed in the past few decades. The final results depend mainly on the site and extent of the primary tumor and on the presence of metastases to the regional lymph nodes. In most cases the treatment still includes surgery in combination with radiotherapy, both of which must be coordinated. Complete treatment of the primary tumor and of the lymph node areas is of great importance even in non-advanced cases. Extensive resection of the tumor offers another mode of curative therapy, especially in combination with reconstructive surgery. Chemotherapy appears to be useful in this group of tumors, but only if aggressive cytoxic agents are given. However, it cannot replace the modalities of treatment mentioned above. Patients with speech and mastication disability after therapy usually need special care. Periodic controls are necessary for even longer than five years, to ensure detection of possible recurrences and second tumors.

Adult↗
PubMed1976

[Current state of radiotherapy of mouth neoplasms].

Beside surgery and chemotherapy, which has recently become important, radiotherapy is an efficacious means in the treatment of oral cavity cancer, both when applied alone and in combination. Clinical radiotherapy is based on the differences in sensitivity between normal tissue and tumor. The radiosensitivity of oral cavity cancers--above all squamous cell carcinoma--may even be considered to be mediocre: therefore a dose should be reached in order to destroy the malignant growth. In percutaneous radiotherapy orthovoltage is without any prospects; high-energy methods, above all telecobalt, have certain advantages, particularly the lower absorption in the bones. In "brachytherapy" we prefer the artificial nuclides 137Cs and 60Co instead of 226Ra for moulds and 198Au grains for interstitial application. At first the radiotherapist has to decide whether to advise radical or palliative treatment. Patients with secondary nodes in whom "radical surgery is inadvisable should have radical radiation therapy..." (Gibb and Todd) in a dose of nearly 5000 rads. Radiotherapy after an inradical neck dissection is burdened with a therapy before surgery can be considered in select cases. The treatment of oral cavity cancer should be practiced in close cooperation between the surgeon and the radiotherapist.

Carcinoma, Squamous Cell↗
PubMed1995

[Problems with treatment in patients with tongue and/or floor of the mouth neoplasms].

From 1974 to 1993 in Otolaryngology Department of County Hospital No 1 in Rzeszów, Poland in 98 patients cancers of the oral tongue and/or floor of the mouth have been diagnosed. Pathology examinations revealed squamous cell carcinoma in 98% of the total number of patients. Based on the hospital data and control examinations authors have analyzed retrospectively 42 patients (35 male and 7 female, aged 32-90). Because of the advanced stage of the disease as many as 17 patients have applied only palliative treatment. 13 patients were treated surgically followed by radiotherapy and/or chemotherapy, 9 patients were treated with radiation and 3 patients have radiotherapy and chemotherapy. 3, 5, and 10 years survivals have been estimated.

Adult↗
PubMed1990

[Neoplasms of the floor of the mouth. Case reports].

The authors study a group of 61 patients treated for floor of the mouth neoplasms at the Istituto di Oncologia di Torino. They confirm a high incidence of deaths in the first 2 years after treatment in patients T greater than 2 N+, and better survival in patients with stage I-II tumours. The survival does not tend to fall between 5 and 10 years after treatment.

Adult↗
PubMed1996

[Photodynamic diagnosis of neoplasms of the mouth cavity after local administration of 5-aminolevulinic acid].

BACKGROUND: The aim of photodynamic diagnosis (PDD) is the complete visualization of all neoplastic lesions in a tumorous organ after topical or systemic application of a tumor selective photosensitizer. In this investigation we performed semiquantitative fluorescence measurements following topical application of 5-aminolevulinic acid (5-ALA) in 11 patients with neoplastic lesions of the oral cavity. METHODS: Time course and type of porphyrin accumulation were analyzed in neoplastic and surrounding normal tissue by measuring emission spectra of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence at regular intervals for up to three hours following 15 min continuous rinsing of a 0.4% 5-ALA solution. After excitation with violet light of a high pressure xenon arc lamp (375-440 nm), fluorescence images in the red spectral range from the tumor tissue and the corresponding macroscopic visible tumor were recorded with a CCD camera. A quantitative analysis of the fluorescence contrast in neoplastic and surrounding tissue was performed using an optical multichannel analyzer. RESULTS: PpIX fluorescence was detected in the oral mucosa of all patients after local application of 5-ALA. PpIX in neoplastic tissue accumulated earlier in comparison to the surrounding normal tissue. The fluorescence contrast between tumor and host tissue was 10:1 and the maximum fluorescence was measured 1-2 hours following 5-ALA application. CONCLUSION: Labeling of mucosal lesions of the oral cavity with PpIX fluorescence induced by the local application of 5-ALA seems to be a promising diagnostic procedure for neoplastic lesions. Further investigations are required to assess the value of this new diagnostic procedure as a non-invasive and sensitive method for patients with head and neck cancer not only in pre- and postoperative diagnostic studies but also for a fluorescence-guided resection of tumors.

Administration, Topical↗