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PubMed1979

[Finding of the staphyloccoi and streptococci of mastitis on the udder after various ways and means of cleaning].

The presence of mastitis staphylococci and streptococci on the udder's surface of 400 cows was studied following application of various ways and means of cleaning. The presence of agents causing mastitis was determined before and after cleaning the udder. On uncleaned udder surfaces presence of mastitis staphylococci was observed in 52.5% and of mastitis streptococci--39.5% of udders studied. After washing with water mastitis staphylococci--on 12-20% of the udders. Following udder cleaning with solutions of antigerm 50 (0.04%) or yozan CCT (4%), mastitis staphylococci were found on 4% and 6% of the udders, respectively, while mastitis staphylococci--on 2% and 6%, respectively. Udder surface staphylococci belong in 2.2% to II phagous group, in 46.6%--to the III group, and in 37.7% -- to mixed groups. The most frequently encountered phagous types were 6 and 42D.

Animals↗

PubMed1979

[Comparative studies of total milk protein and protein fractions in various forms of bovine mastitis].

The content of total protein was assessed in 112 milk samples and of protein fractions--in 106 samples taken from cows suffering from clinical mastitis, subclinical mastitis, secretory disturbances, latent infection, and normal milk. Total protein increased along with the rise of cell content. It increased considerably also in the secretion of cows suffering from clinical mastitis, but the rise in the milk of cows with subclinical mastitis, secretory mastitis and laten infection was insignificant. In all mastitis forms the content of serum albumins and gamma-globulin rose significantly, while alpha-lactoalbumins and beta-lactoglobulin were reduced. These changes in the protein fractions of milk can be used with certainty in the diagnosis of all forms of mastitis.

Animals↗

PubMed1978

A health program for commercial dairy herds. 4. Changes in mastitis prevalence.

A study of mastitis prevalence in 10 herds which participated in a herd health program is reported for varying periods, up to a maximum of 10 years. The program was based on teat dipping with idophor or sodium hypochlorite teat dip, regular maintenance of the milking machine, and selective dry period treatment of quarters which were classified as infected on the basis of California Mastitis Test score and bacteriological examination of milk samples taken before drying off. The procedures reduced mastitis prevalence (measured in cows being dried off), incidence of clinical mastitis, and disposal of cows due to mastitis. Results obtained were similar to those found in short-term studies of control programs based on teat dipping and dry period therapy. The only significant difficulty which arose in maintaining the control program over 10 years was loss of enthusiasm by farmers for teat dipping. This was usually induced by teat irritation problems apparently caused by teat dipping. The use of a monitoring procedure for mastitis prevalence was important in persuading farmers to return to the use of teat dip.

Animals↗

PubMed1977

Incidence of clinical mastitis in a herd of Holstein cattle.

Incidence of clinical mastitis in 760 lactations of 331 Holstein cows was studied for effects of sire, parity, and month of calving. Incidence of clinical mastitis was higher in hind quarters than fore quarters. Positive correlations between number of cases in one quarter with number in other quarters and between proportion infected in one quarter and proportion infected in one quarter and proportion infected in others indicated that occurrence of mastitis in one quarter was associated with above average frequencies of mastitis in the other quarters of the same cow. Clinical mastitis increased with increase in lactation number up to fourth lactation. Cows calving in January and February more frequently had mastitis than those calving in March and April.

Animals↗

PubMed1979

Evaluation of automatic mastitis detection equipment.

An electronic sensor was evaluated as an instrument for early detection of mastitis. This method involved measuring the conductivity of milk continuously throughout the milking process and then establishing a conductivity ratio. The lowest conductivity measurement of the four quarters was a basis for assessing the degree of mastitis in the other quarters. This assumed that at least one of the quarters was normal at examination and the lowest reading was normal conductivity. The conductivity ratio was evaluated by comparison with the leukocyte concentration and combined leukocyte concentrations and cultural examiniations of milk samples from 1028 quarters. In healthy cows conductivities of milk from each of the quarters were similar. If, however, one or more quarters were infected, this milk showed higher conductivity compared to the noninfected quarter of the same cow. The conductivity ratio correctly identified 69% of the established cases of mastitis. For the Wisconsin Mastitis Test, 93.2% of the normal quarters were detected correctly by the conductivity ratio. Leukocyte counts were frequently high when there was no other evidence of mastitis. We believe the conductivity ratio is effective in detecting mastitis at an early stage of infection caused by most of the pathogenic microorganisms.

Animals↗

PubMed1975

Mastitis; a survey on the inter-dependence of the quarters of a cow.

This survey shows the dependence of the diagnosis "non-specific mastitis" on the method and interpretation of laboratory examination. Failures in bacteriological diagnosis will often lead to quarters being incorrectly diagnosed as being affected by "non-specific mastitis". The main aim of this survey was to study the interdependence of the quarters of cows with regard to laboratory results on mastitis. This survey shows that the criteria "high cell number" and "bacteriologically positive" in quarters have no random distribution. The number of cows with nil or four quarters positive is significantly higher than with a random distribution. Genetical difference in susceptibility could be the cause of the phenomenon. But this survey shows that non-genetical factors as age and difference between herds in level of mastitis are largely involved. It seems impossible in a field survey to estimate the genetical share in the high coincidence of the mastitis criteria within cows. In mathematical statistical analysis of the results in quarter-samples, with the aim to compare two groups of cows, the number of elements to compare is the number of cows and not the number of quarters. Because of the coincidence of mastitis symptoms in individual cows, the possibility for statistical evaluation of quarter results is restricted.

Age Factors↗

PubMed1975

[Interbreed and interspecies variation in the occurrence of subclinical mastitis in cows and buffaloes].

Studied were for subclinical mastitis 3252 cows of the Bulgarian Brown breed, 1409 cows of the Bulgarian Simmenthal breed, 1082 cows of the Bulgarian Red cattle, 341 cows of the Iskar cattle, 1086 cows of the Black and White breed, and 418 buffalo-cows. Established were mathematically dependable variations with regard to the individual sensitivity to subclinical mastitis of the main cattle breeds reared in this country. Highest was the percent of subclinical mastitis in the cows of the Bulgarian Simmenthal breed - 28.22. Bulgarian Brown cows and the cows of the Bulgarian Red breed were equally affected with subclinical mastitis - 25.24 and 25.23 per cent, respectively. In the Iskar and Black and White cattle the values were 12.60 and 12.70 per cent, respectively, i.e., the per cent of subclinical mastitis was more than twice lower as compared with the first three breeds. Buffalo-cows showed high absolute and relative resistance both with regard to subclinical and to clinical mastitis.

Animals↗

PubMed1977

[Comparative studies of methods for the bacteriological diagnosis of mastitis in cows].

Comparative studies were carried out on some methods and nutrient media used for the isolation and identification of mastitis causative agents. Milk from normal andmastitis-affected udder quarters was aseptically sampled and treated under various conditions. Individual samples were simultaneously seeded in different media. The following conclusions were drawn: 1. Milk samples for the diagnosis of mastitis of a subclinical character can be taken at the beginning and at the end of milking. 2. Direct seedings of milk have equal diagnostic value as those of the sediment. With the former the process of bacteriologic treatment of the samples is shortened in time, and the isolation and differentiation of the mastitis agents is rendered feasible. 3. At the present etiologic structure of the subclinical types of mastitis in this country most suitable has proved the blood agar medium in which almost all mastitis causative agents can be demonstrated. 4. Kartashova's medium and the TKT-medium possess a pronounced selectivity with special reference to streptococci and have higher diagnostic value for farms where streptococcus mastitis is prevailing.

Animals↗

PubMed1979

[Mammography in the diagnosis and treatment of non-puerperal mastitis (author's transl)].

Circumscribed or diffuse non-puerperal mastitis is usually associated with local signs of inflammation. In two-thirds of these cases it is possible to demonstrate the radiological features of mastitis. Mammography is an important diagnostic procedure in the demonstration of acute mastitis and its differentiation from an inflammatory carcinoma; it is also valuable in the control of treatment. The success of intensive antibiotic therapy with recovery of normal appearances in the chest can be observed objectively by mammography. In distinguishing mastitis from an inflammatory carcinoma, radiological evidence of regression under the influence of antibiotics is evidence in favour of mastitis.

Adult↗

PubMed1976

Incidence of clinical mastitis in a herd of Jersey cattle.

Incidence of clinical mastitis in 1278 lactations of 390 Jersey cows was studied for effects of lactation number, quarter of udder, month of calving, sire, and milk yield. Results for quarter did not conflict with the usual finding that incidence is higher in rear quarters. A mastitis index based on stage of lactation at which infection occurred had less variation, greater variation among sires, and a continuous distribution, in contrast to the traits porportion infected and number of cases. Mastitis increased with advancing lactation number subsequent to second lactations. Fall calvers may have less mastitis since they would be dry or in late lactation during summer. Incidence of mastitis increased at a decreasing rate as total milk yield in the lactation affected increased.

Animals↗

PubMed1977

Mastitis and other diseases of the goat's udder.

Udder problems of modern dairy goats are similar to those seen in dairy cows. Anomalies of the goat's udder and teats are common, and many may be hereditary. Skin diseases of the udder include viral infections, mange, sunburn, wounds, and staphylococcal dermatitis. There are numerous known causes of caprine mastitis. These include streptococci, hemolytic and nonhemolytic staphylococci, corynebacteria, and mycoplasmas. Diagnosis of mastitis in goats is often difficult, as the udder secretion may remain grossly normal and somatic cell counts in nonmastitic goats are higher than the recognized normal range for cows. The importance of nonhemolytic staphylococcal cultures remains uncertain. Nonhemolytic staphylococci were isolated at the New York State Mastitis Laboratory from 30% of normal halves and from 22% of halves of udders from goats with assorted clinical problems. Treatment and prophylaxis of caprine mastitis closely parallel the standard technique recommended for bovine mastitis.

Animals↗

PubMed1977

[Economic aspects of diseases and dairy herd health programs in the Netherlands with special reference to mastitis (author's transl)].

Animal diseases cause considerable losses among dairy cattle in the Netherlands. Model calculations show that the loss on farm level from animal diseases is approximately Dfl 440.--per cow per annum. Increasing attention is being paid to one of them e.g. mastitis. This disease causing an annual loss on farm level of approximately Dfl 125.--per average cow present (a.c.p.). Currently, a Mastitis Control Program (MCP) is being advocated. When the expected profits and cost of the MCP are analysed, different economic levels can be distinguished. Analysis on farm level showed that, when the MCP is carried out, the average calculated losses can be reduced by half, so that, with the exception of the first years, an increase in income of Dfl. 30.--per a.c.p. is anticipated. When less than 12.5 percent of the quarters are infected and less than 2 or 3 per cent of the quarters show clinical mastitis in a period of twelve months, the expected profits of the MCP are less than the cost. When all the farmers (the "sector") reduce the incidence of mastitis, the expected increase in income will be smaller because of price-effects. From the national point of view, the profitability of the MCP will primarily depend on the national-economic net price of the additional milk production, which should be higher than Dfl. 30.--per 100 kg. to make it pay. Finally, it was evident that production of the same quantity of milk by fewer animals, resulting from a reduction of the incidence of mastitis, is profitable on a national level, because of a decrease in the import of concentrates.

Animal Husbandry↗

PubMed1979

[Distribution and forms of latent mastitis in cows].

A study on the distribution of symptomless mastitis in cows on its forms and onthe percentage involvement of the individual microorganisms isolated in the positively reacting cases was carried out including clinical, cytological and microbiological investigations. The study covered 8 cow farms with a total number of 2377 cows. It was established that 68.42% of the cows suffer from symptomless mastitis and 24.09% of the udder quarters. In 32.39% of the latter cases non-specific mastitis or the so called secretory disturbance was observed, while in 67.61%--bacterial mastitis, which in 50.75% had a subclinical course, while in 17.36--as latent infection. In the samples with pathogenic microorganisms 72.35% had staphylococci, 14.32%--micrococci, 8.39%--streptococci and the remaining 4.94%--other kinds of bacteria. The appearance and distribution of symptomless mastitis in cows is the result of bad management of cow rearing and use.

Animals↗

PubMed1978

[Difference in susceptibility to mastitis between the Dutch-Friesian and Meuse-Rhine-Yssel breeds of cattle (author's transl)].

A randomized study in the Netherlands showed that symptoms of mastitis were more common in animals of the Meuse-Rhine-Yssel breed than they were in those of the Dutch-Friesian breed. The samples were taken at random from large groups of animals (approximately 10,000) of the dairy cattle population in the Netherlands, quarter samples being examined for the presence of the causative organisms of mastitis and cell counts being made. Differences between the two breeds were also observed in herds on the experimental farm "'t Gen" on which the animals were reared and kept in the same environment. Therefore, there is some justification in defining these differences as genetic. The results of the studies suggest that a group of animals showing lower cell counts during the first lactation will be less susceptible to mastitis. Studies in a cow-house of the Central Veterinary Institute revealed a significant difference in increase of the cell count between animals of the Dutch-Friesian breed and those of the Meuse-Rhine-Yssel breed following intramammary injection of a staphylococcal beta toxin. Further analysis of the results of the randomized study showed that differences in susceptibility to mastitis do not become plainly apparent until later in life. In view of the results of these studies, it would seem advisable to pay more attention to differences in susceptibility to mastitis in stock-breeding.

Age Factors↗

PubMed1977

Role of teat dips and hygiene in mastitis control.

The primary sources of mastitis pathogens are infected quarters, chapped, sore, or eroded teat ends, and the environment. The major means of transfer of the most predominant mastitis pathogens is the milking routine. Methods are available to reduce the number of organisms normally transferred during each of the procedures. However, with the exception of teat cup pasteurization, the application of hygienic procedures in herds where teat dipping is practiced did not result in additional beneficial effects. Effectiveness of 4% chlorine, 0.5 and 1% iodine, and 0.5% chlorhexidine teat dips has been demonstrated in field trials and should be the preferred products in a mastitis control program. Most gram-negative organisms get on teats by direct contact with the bedding. In herds with clinical coliform mastitis, changing the bedding material has been associated with fewer clinical mastitis cases.

Animals↗

PubMed1977

Tuberculous mastitis. A review of 34 cases.

During a review of 67 cases of mastitis, 34 were diagnosed as cases of tuberculous mastitis. The majority of the patients with tuberculous mastitis were Black women. The mean age of the patients was 34 years. One patient was lactating and several were of postmenopausal age. All presented with unilateral breast masses, thought to be inflammatory in 10 and neoplastic in 10. In none was tuberculosis suspected clinically. The diagnosis of tuberculosis was based on the histopathological demonstration of tubercles, caseation and a granulomatous inflammation, with acid-fast bacilli in 5 instances. The differential diagnoses included duct ectasia, a foreign-body giant-cell reaction with fat necrosis, foreign material or an abscess, granulomatous mastitis, fungal mastitis, sarcoidosis and a syphilitic gumma.

Adolescent↗

PubMed1976

[Characteristics of the staphylococci isolated from the udder of cows with mastitis].

A total of 175 strains of Staphylococcus aureus and 67 strains of Staphylococcus epidermidis were studied, isolated from 486 samples of milk secretion taken aceptically from the individual quarters of the udder of cows affected with subclinical and purulent (clinical) mastitis. The staphylococci were referred to as the causative agent of mastitis in case they were the only microflora in the seedings of the investigated material. Tests were applied as given in Fig. 1 to characterize the strains. It was found that mastitis in cows could be due to both plasma coagulating staphylococci (Staphylococcus aureus) and coagulase-negative Staphylococcus epidermidis organisms. The two Staphylococcus species were isolated from cows with clinical and subclinical mastitis. The division between pathogenic and nonpathogenic Staphylococcus strains by the plasma-coagulating symptom proved impossible, and this made it necessary to use other tests for pathogenicity. It became evident that the thing Staph. aureus and Staph. epidermidis had in common when isolated from cows with mastitis was the production of a gold-like pigment and delta hemolysin. Similarly to Staph. aureus isolated animals, the bovine Staph. epidermidis organisms did not possess fibrinolysin and rarely produced hemolysin. The isolated organisms belonging to the coagulase-positive staphylococci corresponded by their basic properties to Staphylococcus aureus var. bovis as described in the literature. The cultures of Staphylococcus epidermidis isolated under similar conditions showed in a considerable per cent of the cases somewhat different behaviour.

Animals↗

PubMed2026

Long non-coding RNAs link DNA methylation to immune regulatory networks in bovine subclinical mastitis.

Long non-coding RNAs (lncRNAs) are emerging as important regulators of inflammatory and immune signaling, yet their contribution to bovine subclinical mastitis remains poorly defined. Here, we characterized the lncRNA expression landscape associated with disease in milk somatic cells of healthy and subclinical mastitic Vrindavani cattle. We identified 11,403 high-confidence lncRNAs, of which 104 were differentially expressed in subclinical mastitis (adjusted P < 0.05; |log2FC| ≥ 1), with the vast majority upregulated in mastitic samples. Predicted cis- and trans-associated target analyses identified 637 non-redundant genes, and KEGG analysis identified 8 significantly enriched cis-associated pathways and 152 significantly enriched trans-associated pathways (adjusted P < 0.05), predominantly enriched for immune and inflammation-related pathways. These findings prioritized a subset of mastitis-associated lncRNAs for subsequent methylation and interaction-network analyses. A subset of these lncRNAs further overlapped differentially methylated regions (DMRs), suggesting a potential association between lncRNA expression changes and DNA methylation alterations. Integration of lncRNA-miRNA and miRNA-mRNA interactions identified lncRNA-miRNA-mRNA interaction networks involving DMR-associated lncRNAs. Among the prioritized candidates, MSTRG.28878.1 showed overlap with a hypomethylated promoter-associated DMR, increased expression, and multiple connections within the predicted interaction network. Together, these findings identify candidate lncRNAs, methylation-associated loci, and predicted molecular interactions associated with bovine subclinical mastitis and provide a resource for future functional investigation of candidate non-coding RNA-associated mechanisms in disease.

Animals↗