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27 records · Page 2Linked to original sources
PubMed1978

The effect of mercury derivatives of fluorescencein on allotransplant kidney in experiment.

Mercurascan (MSC), a mercury derivative of fluorescein, was studied as to its effect on the survival of allogeneic kidney grafts in dogs. A single perfusion of the donor's kidney with saline solution with MSC added in a ratio of 1 mg/100 ml was found to have significantly extended the graft survival time from 10.8 days (SE +/- 0.6) to 15.4 days (SE +/- 1.6). Graft survival time extension proved to be even more significant after a single dose of MSC given to the donor (0.5 mg/kg b.w.) and repeated administration of an equal MSC dose to the recipient twice weekly. Listed are detailed morphological changes in tissue specimens from the kidney, lymph nodes, spleen, and many other organs of a dog surviving for 42 days. A very moderate rejection lesion with merely tiny lymphocytic infiltrates was proved in the kidney. Lymph node structure was almost entirely obliterated with lymphoid tissue extinction. There was loss of white pulp in the spleen. The absence of morphological changes in the other organs suggested good tolerance of the preparation. More studies are called for to elucidate the complex MSC intervention in the process of rejection.

Animals↗
PubMed1979

[Local therapy of burns in childhood by tanning with povidone-iodine (author's transl)].

Since the end of 1974 we have used Betaisodona instead of Mercurochrome for Grob's three stage tanning because the harmful effects of the mercury contained in the Mercurochrome could not be excluded with certainty. The results were compared in 80 patients in each case. The two groups were comparable with regard to age, degree and extent of the burns. We obtained an equally firm and rapidly drying scab using Betaisodone as with Mercurochrome. Complete loosening of the scab took 16 days with Betaisodona and 14 days with Mercurochrome. Wound infection was no more frequent than with Mercurochrome disinfection.

Administration, Topical↗