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PubMed2026

Underrepresented voices in a Colorado Biobank: Perspectives from focus groups on motivations, return of results, and data sharing.

Most participants in large cohorts, such as biobanks, are of European descent. This lack of representation has been an ongoing challenge in genomic research. Understanding the perspectives on genomics research and participation in biobanks of historically underrepresented populations could provide insight into ways to better engage with these groups. We conducted a series of virtual and in-person focus groups with individuals who self-identified as American Indian or Alaska Native (AI/AN), African American/Black (AA/B), or Hispanic/Latino (H/L) and who were enrolled in the Colorado Center for Personalized Medicine (CCPM) biobank. The focus group discussions were centered on participant experiences, including but not limited to their motivations, return of results, and data sharing. There was a total of 23 participants across the six focus groups. The majority of participants identified as AI/AN (60.9%), followed by H/L (39.1%), and AA/B (21.7%); many participants identified with multiple race/ethnicities. The motivations for participating in the biobank included the potential to advance science and health, the potential for return of results, to learn more about one's ancestry, and a few indicated that they were interested in helping the biobank be more representative of all populations. Notably, many expressed positive feedback of the focus groups and felt that their views were valued, illustrating the importance of community-centered work. Our findings can be used to guide recruitment and engagement of biobank participants, especially from diverse backgrounds, contributing to enhanced partnerships advancing knowledge and healthcare.

biobank↗
PubMed1979

Characterization of the Bacillus subtilis motile system driven by an artificially created proton motive force.

Transient swimming was induced in energy-depleted cells of Bacillus subtilis by an artificial proton motive force, which was created by valinomycin addition and a pH reduction. This system did not require any ions except protons in the medium. The size of the induced motility was strongly influenced by changes in the size of either the K+ diffusion potential or the pH gradient. A rough estimation indicated that a proton motive force higher than -100 mV was required for induction of translational swimming of the cell. Corresponding with the transient appearance of swimming, a rapid but transient efflux of K+ and influx of H+ were observed. With decreases in the rate of H+ influx, the amount of motility decreased. A rate of H+ influx higher than 0.2 mumol/s per ml of cell water gave translational swimming. These results suggest direct coupling of H+ influx to rotation of bacterial flagella.

Adenosine Triphosphate↗
PubMed1978

[Technics of measuring the motive force of very small ameboid cells].

A technic have been perfected which measures directly the motive force of very small ameboid cells and indicates the tropism of the amoeba. By using this technic, the motive force of Entamoeba histolytica was measured. It varied between +/- 1.5 x 10-4 dyne. We have also shown chimiotactism in Entamoeba histolytica. The metabolic coumpound excreted by this cell induced negative tropism.

Cytoplasmic Streaming↗
PubMed1978

Motivation for vasectomy.

Men under 35 tend to request vasectomy for different reasons from those given by older men. Potential sexual, marital, or ageing problems seemed to motivate older couples, and problems related to family size, recent pregnancy, and difficulty with contraception the younger ones.

Adult↗
PubMed2026

Functional Reading Activities to Motivate and Empower: Maintenance of Reading Outcomes for Young Adults With Intellectual and Developmental Disabilities Following a Randomized Controlled Trial.

PURPOSE: This study examined whether the effects of Functional Reading Activities to Motivate and Empower (FRAME), a functional, strategy-based reading comprehension intervention for young adults with intellectual and developmental disabilities (IDDs), were maintained 6 months following the completion of the intervention and explored participants' perceptions of the intervention's feasibility, relevance, and perceived impact. METHOD: Participants were 44 young adults with IDDs (ages 18-26 years) who participated in a previously reported randomized controlled trial (FRAME participants: n = 23; controls: n = 21). Trial outcomes were assessed via telepractice at pretest, posttest, and 6-month follow-up. Six-month maintenance analyses focused on outcomes that demonstrated significant posttest group differences: use of (a) reading comprehension strategies (proximal) and (b) reading comprehension questions (distal). Participant perceptions (social validity) were collected post-intervention from FRAME participants using a structured interview protocol with closed- and open-ended items. RESULTS: At the 6-month follow-up, FRAME participants demonstrated sustained but reduced improvements in strategy use relative to controls (p = .040). Between-groups differences were not maintained for reading comprehension questions (p = .091). Participants reported high acceptability and perceived relevance of FRAME, with qualitative themes reflecting perceived improvements in comprehension, self-improvement, and increased independence. CONCLUSION: Findings suggest that FRAME supports sustainable gains in reading comprehension strategy use and is perceived as meaningful and feasible for young adults with IDDs, although additional supports may be needed to promote sustained improvements in distal comprehension outcomes. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.33307218.

Humans↗
PubMed1978

Motivating and rewarding the staff nurse.

In meeting the economic and professional need for staff nurses to stay at the bedside, a system established at one medical center uses four methods to motivate and reward the staff nurse. They are: recognition and monetary reward, rural nursing experience, cross-training, and inservice participation.

Career Mobility↗
PubMed1977

[Causes, motivations and tendencies of suicidal acts in old age (author's transl)].

The conditioning problems of suicidal acts of aged people were described by demonstrating the results of investigations in 125 patients (over 65 years). The control group consisted of 3004 suicidal patients below 65 years. Depression has been the prevailing psychiatric diagnosis (50% in contrast to 33% in the control group). 24% of the patients alleged conflicts with partners or other relatives as a motivation for the suicidal act. Fear of somatic illness or social isolation follows next. It is remarkable that vocational or economical conflicts were not mentioned. At last prevention problems were discussed. The need for modifying the attitude toward the aged was stressed.

Aged↗
PubMed1978

The University of Rochester predental program: finding and motivating potential dental students.

While many dental schools have cooperative programs with various undergraduate schools, the University of Rochester has developed a unique program that emphasizes dental career opportunities and demonstrates how dental research relates to other disciplines. Through active participation in research, predental students become more highly motivated and appreciate more fully the relationship of dentistry to other aspects of health care. Dental schools benefit from such a predental program in that they are presented with a more complete picture of the dental school candidate. In addition to his grades and biographical data, they have an indication of his interests, his creativity and how well he functions in a research environment.

Curriculum↗
PubMed1979

[Periodontal treatment requirements, motivation and information levels in a groups of 35-year-old Zurich residents].

A representative sample of 35-year old residents of Zurich was examined with the PTN-system to determine their periodontal treatment needs. 8.8% required no periodontal treatment. An additional 7.0% required only oral hygiene instruction and motivation to restore their gingival health. 37.1% of the sample needed removal of marginal irritants. 47.1% of the sample population had periodontal pockets in two or more quadrants, in need of surgical treatment (curettage, flap surgery). Responses to a questionnaire completed by all participants in the study revealed a strong desire on their part to retain their teeth. However, knowledge of periodontal prophylactic measures and individual oral hygiene was inadequate.

Adult↗
PubMed1979

[Patient motivation by application of an individual intensive program for obtaining oral health].

The failure of group and individual dental prophylaxis based upon an authoritarian relationship between doctors and patients is demonstrated. In a new information and motivation program, the Hygiene Intensive Program (HIP), the patient's attention is focused on gingival bleeding as an unmistakable warning symptom of oral disease. The degree of marginal inflammation is scored using the Papillary Bleeding Index (PBI). The HIP is designed to introduce trust and confidence into the cooperative efforts of the dentist and the patient. The patient can see the increasing success of the dentist's work and judge the effect of his personal oral hygiene efforts. The possibilities for the cooperation of the increasingly involved third party of the dental "Troika", the actual purchaser of dental services (health insurance, social welfare system, etc.) in the HIP are discussed.

Gingival Hemorrhage↗
PubMed1979

The effect of amitriptyline and mianserine (Org. GB94) on food motivated behaviour of rats trained in a runway: possible correlation with biogenic amine concentration in the limbic system.

Rats on a 23 h food deprivation schedule were trained to run down a straight runway for a food reward. Neither amitriptyline nor mianserine had an effect on the running time for the food reward during the period of continuous reinforcement. However both antidepressants delayed the extinction of this response. It seems unlikely that this effect on extinction was due to an altered motivation for the food reward as amitriptyline significantly decreased the food intake of the experimental animals while mianserine increased the food intake throughout the period of the experiment. The observation that both these antidepressants reduce the speed of extinction of rewarded behaviour may be explicable in terms of observed changes in the concentration of biogenic amines in the limbic system.

Amitriptyline↗
PubMed1979

[Role of proton motive force in the infection of E. coli K-12 cells by bacteriophage T4].

It was shown that infection of E. coli cells by phage T4 is suppressed, when the cells are treated by oxidative phosphorylation uncouplers. The inhibiting effects of the uncouplers manifest themselves at the stage of phage DNA entry into the cells. Study of the E. coli cells devoid of their H+-ATPase activity due to mutation showed that the infection is suppressed by a switch-off of the respiratory chain, the only generator of the proton motive force (PMF) in mutated cells. Infection of the E. coli cells containing intact H+-ATPase occured even in the case when the respiratory chain activity was inhibited. The kinetic studies showed that generation of PMF is necessary during phage DNA transport into the cells and is indispensable for phage DNA entry into bacterial cells.

Adenosine Triphosphatases↗
PubMed1977

A cortical evoked potential that reflects the conditioned, positive incentive value of the stimulus. II. Drive motivation (hunger).

It was shown that the late negative wave evoked in squirrel monkey cortex by tone cues signalling the availability of reward was smaller when the animal did not respond to the cue and often disappeared if the animal ignored many cues in succession. It decreased in amplitude as a test session progressed, and the rate of this decrease increased if the rate of reinforcement was increased. In some animals the size of the evoked wave was smaller if the animal was not fasted before a test session. In some animals the average size of a significant positive correlation with the number of cues responded to and a negative correlation with the animal's average reaction time. It is concluded that the evoked wave is probably a reflection of the conditioned incentive value of the cue.

Animals↗
PubMed1977

A cortical evoked potential that reflects the conditioned, positive incentive value of the stimulus. III. Manipulative motivation and the value of the reward.

Changing animals from a schedule on which they had to bar-press after a tone cue to get a food pellet, to a schedule on which the food pellet was presented automatically after the tone cue and the manipulandum was not available, had no effect on the latency, amplitude, or shape of the M-wave evoked by the tone cue. The amplitude of the evoked wave did, however, decrease more rapidly, as a test session progressed, with the latter schedule than with the former schedule. Failure to fast animals before test sessions markedly reduced the amplitude of the M-wave. Variation in the type of food pellet used caused marked variations in the amplitude of the evoked response. In all cases, there was a high degree of correlation between M-wave amplitude and a behavioral indication of the animal's interest in the reward. It was concluded that the M-wave reflects the conditioned incentive value of the cue, or in other words, the level of interest of the animal in the reward.

Animals↗
PubMed1976

Alterations in the behavioral effects of LSD by motivational and neurohumoral variables.

Forty naive male albino rats were trained to press a bar on a fixed-ratio (FR 32) schedule of water reinforcement. They were then divided into two groups, one of which (N = 20) received 5 min of extra water 12 hr before each experimental session; the other group (N = 20) received no extra water. Half of the animals in each group was given three daily doses (100 mg/kg) of the trytophan hydroxylase inhibitor p-chlorophenylalanine methyl ester (PCPA) while the remaining animals were given control injections of the PCPA vehicle. Ten days following the last administration of PCPA (or vehicle) all animals were given a low dose of LSD (20 mug/kg). Bar-pressing behavior was significantly disrupted only in those animals receiving both PCPA and extra water. Central (whold brain) concentrations of serotonin (5-HT) were significantly lower in all animals which had been treated with PCPA. These results, along with those previously reported, suggest that amount of deprivation can be an important determinant of both the ability of drugs to alter behavior and the dependence of such alterations upon underlying neuronal activity.

Animals↗