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A controlled trial of multiphasic screening in middle-age: results of the South-East London Screening Study. The South-East London Screening Study Group.

The results of a controlled trial of multiphasic screening in general practice are presented. In 1967, 7,229 individuals aged between 40 and 64 years were randomly allocated into either a Screening or Control group. The Screening group were invited to attend two screening sessions held about two years apart, while the Control group continued to receive conventional medical care. Both groups were then invited to undergo a health survey in 1972-73 which revealed no significant differences in morbidity between the two groups. Careful follow-up permitted detailed Screening-Control comparisons of various outcome measures--consultation and hospital admission rates, certified sickness absence from work, and mortality. Nine years after the initial screening, no significant differences were found between the two groups in any of the outcome measures. It is estimated that a similar screening programme for the entire middle-aged UK population would cost 142 pounds million at 1976 prices.

Aged↗

Patient education and multiphasic screening: it can change behavior.

Two hundred ninety-two residents of Sonoma County, California, underwent multiphasic screeening and two sessions of group patient education aimed at reducing risk factors for cardiovascular disease, cancer, and automobile accidents. Approximately one year later all the participants were retested. A significant reduction was noted in systolic blood pressure in men and women, ages 50 to 70, cholesterol in men over age 40, and reported alcohol consumption in men. A significant increase was noted in the reported frequency of monthly breast self-examination in women, and in the amount of exercise and percentage of time seat belts were used in both sexes. No change was noted in reported amount of cigarette smoking, weight, fasting blood glucose, and triglycerides. The combined use of health hazard appraisal, multiphasic screening, and patient education can lead to a reduction in cardiac and other risk factors in well-motivated groups.

Adult↗

["Multiphase screening" in big industrial city].

Reported in this paper are results obtained from a scheme of computer-backed multiphase screening which has been conducted, with reference to a programme of WHO, for early detection of precursor and early phases of cervical carcinoma and for early detection of patients with hypertension. Evaluation included 54,088 prophylactic examinations through four and a half years. Notifiable diseases of the uterine cervix were recorded from 4.8% of all probands. Among them were 44 cases of severe dysplasia, 156 cases of in situ carcinoma, and 62 cases of invasive cervical carcinoma -- Complementary findings were obtained from 11.8 per cent of the cases. Clinical treatment of patients for such complementary findings were required by more than one in 100 women examined. Another 28 carcinomas were diagnosed and treated, in that context. -- Only 54,020 data were evaluated, in the context of the hypertension screening programme. Hypertension, originally unknown in more than 50 per cent of all cases, was recorded from 19.4 per cent of these women. At total of 16,714 women (42.2 per cent), aged between 20 and 49 years, was on hormonal contraceptives, and hypertension had grown manifest in 12.2 per cent of these.

Adult↗

An evaluation of multiphasic screening on admission to hospital. Precis of a report to the National Health and Medical Research Council.

A controlled study of admission multiphasic screening (AMS) at a large general hospital showed that AMS had no significant effect on a variety of indices of inpatient progress. Owing to a 64% increase in estimated cost of investigations with AMS, the total hospital admission cost was increased by approximately 5%. Under the conditions of this study, AMS added to the cost of hospitalization without associated evidence of benefit to the patient.

Australia↗

Preemployment multiphasic screening in an urban manpower training program.

Preemployment health examinations have long occupied a central role in industrial medicine, providing company physicians with baseline health status and physical limitations for each employee. We evaluated a similar multiphasic screening examination in 662 young, minority applicants to an urban manpower training program. Resulting from this screening was a substantial number of patients with positive serology (1%), positive gonorrhea cultures (3%), excessive daily ethanol ingestion associated with liver enlargement (13%), decreased visual acuity (24%) and dental caries (23%). These findings are markedly different than those reported for preemployment screening in industry, suggesting the need for a specific health screening protocol for applicants to manpower training programs.

Adult↗

Repeated multiphasic screening examinations: evaluating the process.

There are sound clinical and epidemiological reasons to promote and emphasize early detection efforts and disease prevention services. A large body of scientific literature supports the notion that detection and intervention early in the course of many diseases is beneficial both to the afflicted individual and to society at large. Several publications deal with the evaluation of multiphasic screening examinations (MSE) as a tool for simultaneous early detection and prevention of multiple risk factors and various diseases. Usually, this technology is evaluated based on data from a single (cross-sectional) comprehensive screening study. However, frequently MSE are performed periodically, resulting in repeated test results of the same individuals. The health impact of such repeated (longitudinal) MSE has not been studied extensively. Similarly, many of the unique theoretical, technical, and epidemiological features characteristic of consecutive (periodical) comprehensive screening examinations are not well-documented. The purpose of this study was to compare the test results of two MSE, performed 3.5 years apart, in order to demonstrate certain characteristics of multiphasic health testing (MHT) technology related to repeated (longitudinal) multiphasic examination of the same individuals.

Humans↗

Periodical multiphasic screening and lung cancer prevention.

The purpose of this work is to evaluate the utilization of information gathered by multiphasic screening with respect to lung cancer detection and smoking cessation techniques. A cohort (follow-up) study is reported in which cancer incidence and factors affecting its occurrence are evaluated in a group of about 20,000 presumably healthy adults along a period of approximately 10 years following comprehensive multiphasic health examinations. Lung cancer occurrence is primarily related to smoking. The risk is higher in smokers and is dose-dependent; OR = 0.21, (CI = 0.08, .53) in never smokers, OR = 1.53 (CI = 0.8, 3.2) in past and current moderate smokers, OR = 4.92 (CI = 2.18, 11.11) in current heavy smokers. Moreover, smokers with compromised pulmonary function (FEVI/FVC < 75%) are at an even higher risk of developing lung cancer OR = 4.22 (CI = 2.2, 8.2) for past and current moderate smokers; and OR = 10.7 (CI-2.5, 38.6) in current heavy smokers. Information gathered in periodical multiphasic health examinations could be utilized by health professionals to encourage smoking cessation and smoking prevention in the appropriate screenees. Various elements of the multiphasic test results could contribute to such prevention efforts. While every smoker should receive appropriate evaluation and consultation regarding nicotine dependence, smokers with reduced pulmonary function represent an extra high risk group to which special attention should be given.

Adult↗

[Multiphasic screening in a large industrial city. 2].

By the programme for detection of patients suffering from hypertension as appendage to the electronic data processing project "early detection of carcinoma of cervix uteri" in 54,020 examinations 10,469 women with hypertension were discovered and sent to competent specialists for continued observation and treatment. The portion of unknown hypertensions was 58.3%. In the examined female population of Karl-Marx-Stadt aged 20 to 65 years the prevalence of hypertension was 19.4% and corresponded to the results of national and international studies. - 16,714 women in the mainly fertile age were on hormonal contraceptives. The blood pressure of these women and of a comparable group without hormonal treatment was examined, the results were discussed. The histories did not allow to make conclusions for a certain disposition caused by the diagnosed hypertension. Moreover, our dates could not answer, if and which ranges the blood pressure (systolic and/or diastolic) increased in particular case.

Adolescent↗