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Results for “NEOPLASMS, MULTIPLE PRIMARY”

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At least 37 records · Page 2Linked to original sources
PubMed1998

[Primary multiple neoplasm of the endometrium and adjuvant hormone therapy in patients with breast cancer].

The contribution made by adjuvant hormone therapy in the development of primary multiple endometrial adenocarcinoma (EA) in patients with breast tumors (BT) is not quite clear. The study was based on the data on 5,790 cases of BT treated at our Clinic and 4,447 females screened for hormone-dependent neoplasms. Patients with BT were found to be at high cumulative risk for endometrial carcinogenesis caused by general factors of risk and pathogenesis. The risk was particularly high in BT (stage 1) within 12 months after treatment. There was no correlation between tamoxifen treatment and significant increase in EA frequency. Promotion of tumor proliferation by tamoxifen was identified in endometrial tissue in 62 patients with BT. This may facilitate clinical manifestations of another latent EA in such patients. Dynamic surveillance of the endometrium and ovary should include ultrasonography of pelvic organs and cytologic examination (smears) of the ecto- and endocervix and endometrial aspiration biopsy.

Antineoplastic Agents, Hormonal↗
PubMed1986

Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors.

The exact risk of multiple primary neoplasms in patients with salivary gland or thyroid gland malignancies is difficult to ascertain from the data available in the literature. This study examines, retrospectively, 198 patients with a first malignancy of the salivary gland and 186 patients with a first malignancy of the thyroid gland, treated over a 10-year period. Fourteen cases of second tumors were found in the first group and 29 cases in the latter. Patients whose second neoplasm was a skin cancer or who had a previous neoplasm at a site other than those selected for study were excluded. The risk of a second tumor compared to the expected number of second cancers from the Combined National Cancer Institute Registry Data, and the results indicated an increased risk in males with a first malignancy of the salivary gland and in both men and women with a first thyroid malignancy. The salivary glands, larynx, and colon were the most common sites of second tumors after a first salivary cancer. The adrenals, brain, lymphatic system, and breast were the most common site after a first thyroid cancer. The previously reported association of cancers of the thyroid and the breast in females is confirmed here in men and women. The excess of brain tumors and lymphomas has not been reported previously.

Adolescent↗
PubMed2002

[Surgical treatment of multiple primary neoplasms].

Comparison of two groups of patients with polyneoplasia was carried out: in group 1 surgeries were performed simultaneously, in group 2--at different time. Choice of surgical technique seems to depend on the time between detection of the tumors. When polyneoplasias were revealed at the same time, surgeries were performed simultaneously. These operations were conducted more often when the tumors were localized in organs accessible by one surgical approach. When multiple synchronous tumors located in various anatomic regions consecutive operations were performed more often. The stage of the tumor does not influence the choice of time of operation for the first and second tumor. Simultaneous operations are preferable for young patients without concomitant diseases.

Abdominal Neoplasms↗