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At least 37 records · Page 2Linked to original sources
PubMed2006

Fibroepithelioma of pinkus.

An 88-year-old woman presented with an 8-year history of a slowly enlarging growth on the suprapubic area. A shave excision of this lesion demonstrated fibroepithelioma of Pinkus (FEP). Fibroepithelioma of Pinkus is an indolent growing tumor that traditionally has been classified as a variant of the basal cell carcinoma. More recent evidence favors the classification of FEP as a variant of trichoblastoma. In this case report, we identified a large FEP with benign histologic features suggestive of a follicular origin as demonstrated in part by CK 20 staining and the presence of scattered Merkel cells within the tumor. The pathogenesis of FEP remains enigmatic, and the genetic basis has yet to be fully elucidated. Complete surgical resection is considered curative.

Aged, 80 and over↗
PubMed2004

[Pseudosarcomatous variant of a genital fibroepithelial stromal polyp in a pregnancy].

Fibroepithelial stromal polyps are benign neoplasms of the lower genital tract occurring mostly in young to middle-aged women in their reproductive years. Clinically they appear as tender, skin-colored, sack-like tumors and usually have a bland microscopic appearance. Sometimes, especially during pregnancy or with hormone therapy, a worrisome hypercellular and pseudosarcomatous pattern can be seen in the dermis. Awareness of this neoplasm with a possibly high degree of atypia is of crucial importance in order to avoid unnecessary radical surgery.

Adult↗
PubMed2001

[Multiple fibrofolliculomas].

Fibrofolliculoma is a rare tumor of the perifollicular mesenchyma. A 44-year old man noticed a growing number of small whitish firm papules on his neck and the upper thorax over the past two years. Histological examination demonstrated on multiple biopsies typical features of fibrofolliculoma. Further evaluation of the patient has not revealed any sign of neoplasia. The variable clinical manifestations of fibrofolliculomas are discussed.

Adult↗
PubMed2004

[Benign fibroepithelioma of the ureter. A rare differential diagnosis for pain-free macrohematuria].

Gross hematuria without pain is a classical symptom of malignancy in the urinary tract. Despite the presence of other symptoms such as a history of heavy smoking or radiologic evidence of tumor growth, it may still be caused by a benign lesion. This is demonstrated by the case of a 38 year old man with a fibroepithelioma of the left ureter. While discussing the differential diagnostic and treatment procedures it is shown that even in the era of modern non-invasive imaging techniques there is still an important place for retrograde ureteropyelography in the evaluation of the upper urinary tract.

Adult↗
PubMed2005

A rare case of bladder fibroepithelial polyp in childhood.

OBJECTIVE: To present a rare case of a benign polyp in a child. Very few cases of urinary tract fibroepithelial polyps in the bladder are reported in the international literature and they are even less common in children. MATERIAL AND METHODS: A 14-year-old boy presented at the Urology Department of "Elpis" Hospital complaining of painless macroscopic hematuria during the last six months. The patient did not report previous urinary tract disorders. After a thorough laboratory investigation, which included urinalysis, urine culture, ultrasonography, intravenous pyelography and cystoscopy the presence of an exophytic papillary tumor in the bladder was identified. The lesion was removed transurethrally. RESULTS: The biopsy set the diagnosis of fibroepithelial polyp, which is a rare benign neoplasm and occurs in patients of nearly all ages. Polyps are located usually in the ureteropelvic junction, the upper third of the ureter and the posterior urethra. They are rarely found in the bladder, especially in the childhood.

Adolescent↗
PubMed2004

Multiple fibroepithelial polyps of the upper ureter in a 17-year-old boy--case report and review of the literature.

Benign tumours and primary malignant tumours of the ureter are uncommon in adults and extremely rare in children. The clinical symptoms are flank pain, urinary tract infection, and macro/micro-haematuria. There is an incomplete ureteral obstruction and filling defect on intravenous urography (IVU). Optimum treatment of this lesion results in renal preservation. Uretero-renoscopy is currently the best method available for the identification and histological diagnosis of ureteral polyps. Recommended operative procedures are pyeloureteric junction (PUJ) resection with Anderson-Hynes pyeloplasty, ureteric resection with end-to-end anastomosis or with uretero-cysto-neoanastomosis (UCNA), ureteric resection with renal autotransplantation. Ureteronephrectomy is not indicated. A case of ureteral polyps in a 17-year-old boy with the chief complaint of left flank pain is reported here. The excretory urogram and renal scan showed left hydronephrosis. Resection of the pyeloureteral junction, partial resection of the upper ureter containing the lesions--multiple branching 30-40 mm long polyps with a common basis--and Anderson-Hynes pyeloplasty were performed. The pathological diagnosis was benign fibroepithelial polyps of the ureter. Convalescence was uneventful and after 4 years of follow-up, excretory urogram and ultrasonography showed good renal function and improvement of hydronephrosis.

Adolescent↗
PubMed2003

[Fibroepithelial polyp of the anterior urethra, found during post-operative follow-up of ureteral cancer].

A 52-year-old man underwent nephroureterectomy against left distal ureteral cancer (transitional cell carcinoma, Grade 2, pTa), and was followed up by surveillance alone. Twenty-two months postoperatively, a pedunculated tumor was found in the anterior urethra by cystourethroscopy. Pathological examination of the tumor resected transurethrally revealed a fibroepithelial polyp. There have been only twelve cases of fibroepithelial polyp of the anterior urethra reported in the literature. Since 4 out of 8 adult cases among them were found during the postoperative follow up period of urothelial cancer, mechanical irritation by repeated transurethral procedures might be responsible for the development of fibroepithelial polyp of the anterior urethra in these cases. If anterior urethral tumor is found during follow-up urothelial carcinoma, benign urethral polyp should be considered in the differential diagnosis.

Carcinoma, Transitional Cell↗
PubMed2006

Dermoscopy patterns of fibroepithelioma of pinkus.

BACKGROUND: Fibroepithelioma of Pinkus (FeP) is a rare variant of basal cell carcinoma that may clinically mimic a number of benign skin tumors. While the dermoscopic features of basal cell carcinoma have been studied extensively, little is known about the dermoscopic features of FeP. OBSERVATIONS: Retrospective evaluation of clinical records and digital clinical dermoscopic images of 10 histopathologically proved FePs (6 nonpigmented and 4 pigmented) was performed. Clinically, no FeP was correctly identified and, in half of all patients, a clinical differential diagnosis of purely benign skin lesions was made. Dermoscopy enabled the correct diagnosis in 9 of 10 FePs, based on the presence of fine arborizing vessels, either alone or associated with dotted vessels, and white streaks (in 100%, 70%, and 90% of lesions, respectively). In the 4 pigmented FePs, a structureless gray-brown area of pigmentation and variable numbers of gray-blue dots were observed, in addition. CONCLUSIONS: Dermoscopy is helpful in diagnosing FeP and in differentiating this variant of basal cell carcinoma from other benign skin tumors commonly included in the clinical differential diagnosis. This presumes, however, that dermoscopy is used as a first-line examination for all skin lesions, not only for those that are clinically suspect.

Adult↗
PubMed2005

Fibroepithelioma of pinkus is a fenestrated trichoblastoma.

Pinkus described "pre-malignant fibroepithelioma" as a proliferation that gave rise to many tiny basal cell carcinomas within each lesion. Later authors have generally considered it to be an unusual variant of basal cell carcinoma (BCC). The delineation of trichoblastoma as the general term for the benign counterpart of BCC raises the possibility that the fibroepithelioma of Pinkus (FEP) would be better classified under that rubric. To address this subject, we examined the records of 114 patients with FEP for body site, age and sex distribution, and sections from 75 lesions. All FEP examined show a blunt interface with the underlying dermis (where one could be seen), differentiation toward follicular bulbs and papillae, and large areas of cellular stroma. FEP has a slight female preponderance in contrast to BCC, which is more common in males. Unlike the common types of BCC, FEP has an overwhelming predilection for the trunk and extremities, and only 5% of tumors are set in a dermis with significant amounts of solar elastosis. Next, FEP, BCC, and FEP with BCC-like areas were stained with MIB-1 (to assess proliferation), p53 (an oncogene product), and CK20 (a Merkel cell marker) antisera. FEP shows a low level of staining for p53 and MIB-1, in contrast to conventional BCCs that over-express these markers. FEP also shows retention of Merkel cells, a characteristic of benign neoplasms with follicular germinative differentiation but not in general of BCC. The BCC-like areas in some FEP tumors reflect these staining tendencies with less striking differences. Given the contrast between FEP and BCC with respect to site of occurrence, relationship to sun damage, histopathologic features, and immunohistochemical studies, it appears that FEP more closely resembles trichoblastoma than BCC.

Adolescent↗