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PubMed1993

[The risk of second primary neoplasm in prostatic cancer patients].

The risk of suffering a second primary neoplasia after bearing a prostate cancer has been evaluated. The study patients attended the Hospital La Fe and were diagnosed between 1984 and 1992. There was a total of 223 prostate neoplasias, 22 of which had associated a second neoplasia and in 12 cases, corresponding to seven tumoral locations, prostate cancer was the first pathology to be diagnosed. Tumours observed were compared to those expected, according to the incidence rates appropriate for each age group and tumoral type, taken from the Spanish section of "Cancer Incidence in Five Continents", 1987. An excess of second neoplasias for vesical, kidney, CNS, bone and lymphoma tumours was found. In most cases, the second tumour was diagnosed between 6 to 12 months after diagnosis of prostate cancer. The patient's prognosis is dependent of the second neoplasia. The possible mechanisms of these associations are discussed in the light of state-of-the-art knowledge.

Adenocarcinoma↗
PubMed1979

Childhood acute lymphocytic leukemia with a second primary neoplasm.

The occurrence of de novo cancer in renal transplant patients who have received immunosuppressive therapy has been noted. An increased incidence of second primary neoplasm (SPN) has been reported in adults with various forms of cancer. The incidence of SPN in childhood cancer is lower. Successful therapy in several childhood cancers has resulted in prolonged disease-free survival time with the opportunity for longer patient-years of observation. The development of a SPN, an astrocytoma, in a child with continuous complete remission for more than 6 years is reported. The incidence of SPN in childhood cancer needs to be established.

Adult↗
PubMed1994

[Risk of suffering from a second primary neoplasm in patients with bladder tumor].

An evaluation was made on the risk of having a second primary neoplasia following vesical tumor diagnosis. All patients attended the 'Hospital La Fe' and had been diagnosed between 1984 and 1993. A total of 238 vesical tumours were studied, 45 (15.9%) with associated second neoplasia; in 34 cases the vesical tumour was the first one to be diagnosed. The number of tumors seen was compared to expected figures, according to the appropriate incidence rates by age, sex and tumour type, taken out from the Spanish section of the 1987 edition of "Cancer Incidence in Five Continents". An increase over the expected values of second neoplasias for lung, prostate, kidney and bone cancer was found. Sixty percent developed concurrently (within 6 months from initial diagnosis). Most vesical tumours were infiltrant, thus conditioning both the prognosis and the second neoplasia. The likely factors implied in this phenomenon are discussed.

Aged↗
PubMed2000

Candidal abscess in a second primary neoplasm of the neopharynx.

A candidal abscess is a known complication of disseminated candidiasis, particularly in immunocompromised patients. We report a second primary growth in the neopharynx brought to light by a candidal abscess in a non-immunocompromised patient.

Antifungal Agents↗
PubMed1999

[Second primary neoplasms in laryngeal cancer patients].

In the period of 1990-1992, 238 patients underwent surgical treatment for laryngeal carcinoma in ORL Department of Medical Academy in Białystok. Until now 27 cases of second primary malignances (SPM) have been found in this group (11.3% of the screened population). Upper aerodigestive tract was the most frequent location, i.e. it was observed in 18 cases (66.6%). There was 100% mortality among patients with SPM of stomach, oesophagus and lung estabishing 13% deaths in the whole group. There was no correlation between the stage and the location of primary laryngeal cancer and SPM. Carcinogenic influence of smoking and alcohol on primary malignancies and SPM within upper aerodigestive tract development has been confirmed.

Adult↗
PubMed2001

Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958-1996: a search for common mechanisms.

The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. Standardized incidence ratio (SIR) of a second malignancy was calculated as the ratio of observed to expected numbers of second malignancies by applying site-, sex-, age-, period-, residence- and occupation-specific rates in the corresponding population in the Database to the appropriate person-years at risk. Among 18 960 patients with non-Hodgkin's lymphoma (NHL), there was over a 3-fold significant increase in cancer of the tongue, small intestine, nose, kidney and nervous system, squamous cell carcinoma (SCC) of the skin, NHL, Hodgkin's disease (HD) and lymphoid and myeloid leukaemia. Among 5353 patients with HD, there was over a 4-fold significant increase in cancer of the salivary glands, nasopharynx and thyroid, NHL and myeloid leukaemia, and over a 1.6-fold increase in cancer of the stomach, colon, lung, breast, skin (melanoma and SCC), nervous system and soft tissues and lymphoid leukaemia. Among 28 846 patients with myeloma and leukaemia, there was a significant increase in cancer of the skin, nervous system and non-thyroid endocrine glands and all HLPD except for myeloma. Our findings showed some clustering between first and second primaries among Epstein-Barr virus-, ultraviolet radiation- and immunosuppression-related cancers.

Adolescent↗
PubMed1978

Second primary neoplasms following ovarian cancer.

Follow-up surveys of patients with ovarian cancer revealed an increased risk of second primary cancers of the uterine corpus, colon, bladder, breast, and hematopoietic system. The excess risk or uterine corpus cancer was independent of therapy. The risk of colon cancer was increased in all treatment groups but was especially high among patients receiving radiation or chemotherapy. The predisposition to other neoplasms was limited to certain treatment groups: bladder cancer to irradiation, leukemia to chemotherapy, and lymphoma to either modality. The pattern of second neoplasms following ovarian cancer appears to be influenced by therapy as well as by common etiologic factors.

Alkylating Agents↗
PubMed1991

A familial RB1 mutation detected by the HOT technique is homozygous in a second primary neoplasm.

Using the hydroxylamine-osmium tetroxide (HOT) technique, we have identified a constitutional point mutation in the retinoblastoma susceptibility gene (RB1) which segregates with the expression of retinoblastoma in five affected family members. One member developed a second primary tumor, a small-cell lung carcinoma (SCLC), which metastasized to the liver. Analysis of liver tumour DNA revealed homozygosity for the constitutional mutation, a G----A transition at the fifth base of intron 21, resulting in the excision of exon 21 from the mRNA. This is the first demonstration of homozygotization of a constitutional RB mutation in a metastatic second primary tumour and underlines the usefulness of the HOT technique for identification of mutations of the RB1 gene.

Adult↗
PubMed1995

[Incidence of second primary malignant neoplasms in patients treated for laryngeal cancer].

Although the survival rates reported for patients with laryngeal cancer are quite good, there is a risk of developing second malignant tumors in this population. From a total analyzed of 1268 patients with laryngeal cancer, the second malignant tumors in 30 persons group were identified. The prognosis for second malignant tumors is poor, especially with tumors of the lung and oesophagus. Vitamin A and carotenoids are promising for second malignancies prevention.

Adult↗
PubMed2006

Secondary free-tissue reconstruction for metachronous tumors of the head and neck: techniques, results, and outcomes.

Malignancies of the head and neck are not uncommon in the Far East due to the habit of betel-nut chewing. The development of a second primary neoplasm is a constant fear for those who have had successful treatment of a primary cancer. A total of 82 patients, treated with microvascular reconstruction after surgical resection of head and neck cancer, were studied retrospectively. Twenty-one patients who had repeated reconstructive microsurgery for a second primary head and neck malignancy were enrolled as the study group. Sixty-one patients treated for the first-diagnosed malignancy were considered as the control group. There were no statistical differences between the two groups, either in terms of operation time, hospital stay, successful rate, or complication rate. The results show that, if required, one should not hesitate to repeat the free-tissue transfer after ablating a second primary neoplasm.

Aged↗
PubMed2004

Multiple primary malignant neoplasms in urologic patients.

METHODS: Second primary cancers constitute approximately 9-10% of malignancies diagnosed in the United States. We aimed to show the risk and incidance of second primary tumor occuring associated to urologic tumors and show the distrubution of tumors in Tracia region. We retrospectively examined the patients' files with the diagnosis of malignant disease between the years 1985-2000. Hazard function analysis was performed to estimate the relative risk of secondary malignancy occuring. Age, sex and tumor number were examined to find out if they affect on mortality rate. RESULTS: A total number of 25 MPMNs were diagnosed. In 52 percent of the cases the second primary neoplasm developed within six months. The relative risk of development of a second neoplasm is found as increasing 1.111 times per month. The incidence of secondary malignancy occuring in the patients with one tumor was found as 6.31%. Age (p < 0.001) and tumor number (p < 0.001) are found as statistically effective predictor on mortality rate where the sex is not. CONCLUSIONS: In the patients with a primary tumor not only the metastasis must be investigated but also second primary tumors should be taken into consideration.

Adult↗