[Calcifying odontogenic cyst associated with odontoma (a calcifying odontogenic tumor of ghost cells associated with odontoma)].
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Adolescent↗
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Results for “Odontogenic Cyst, Calcifying”
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The nature of ghost cells in calcifying odontogenic cyst: an immunohistochemical study.
Two solid and two cystic forms of calcifying odontogenic cysts were stained immunohistochemically to study keratin, carcinoembryonic antigen, epithelial membrane antigen, and S-100 protein expression in ghost cells. The patterns of immunoreactivity were compared with those of dentigerous cysts, odontogenic keratocysts, ameloblastomas, calcifying epitheliomas of Malherbe, and control samples. Immunostaining patterns of calcifying odontogenic cysts were found to be similar to the odontogenic lesions and different from calcifying epithelioma. It is concluded that ghost cells are "keratinizing" odontogenic cells showing aberrant differentiation. These cells should not be regarded as metaplastic. The similarity of the immunostaining patterns of cystic and solid calcifying odontogenic cysts supports the view that these lesions are two morphologic variants of the same entity.
Ameloblastoma↗
Clear cell change in a calcifying odontogenic cyst.
A case of calcifying odontogenic cyst exhibiting clear cell change is described. Histomorphologic similarities to the clear cell type of calcifying epithelial odontogenic tumor were noted and the importance of differential diagnosis from clear cell types of salivary gland neoplasms and metastatic hypernephroma are emphasized.
Adult↗
THE KERATINIZING AND CALCIFYING ODONTOGENIC CYST.
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Calcification, Physiologic↗
Adenomatoid odontogenic tumor arising in a calcifying odontogenic cyst.
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Adult↗
Recurrent calcifying odontogenic cyst involving the maxillary sinus.
The calcifying odontogenic cyst is an uncommon lesion that occurs in both jaws, however involvement of the maxillary sinus is rare. The accepted mode of treatment is enucleation with curettage since it is generally believed that recurrence following such treatment is extremely rare. Of the reported cases of recurrent calcifying odontogenic cysts, none have involved the maxillary sinus. This report is of a large recurrent calcifying odontogenic cyst involving the maxillary sinus, eroding the orbital floor as well as anterior and medial walls of the maxillary sinus and displacing an impacted upper canine into the nasal cavity, in a 45-year-old male patient, 8 years after the initial enucleation.
Cuspid↗
[Calcifying odontogenic cyst. A clinical case].
The calcifying odontogenic cyst (COC) is a rare lesion that involves the jaws which, at times, may evolve into a solid, benign, tumor-like mass. There is no significant sex predilection, but it is probably more common in later life. The diagnosis is base only on histologic examination that represents, in the best of cases, the only way to differentiate the COC from other pathologies. Such lesions include: odontogenic cyst, residual cyst, globulomaxillary cyst, lateral periodontal cyst, ameloblastoma (multicystic and unicystic), odontogenic mixoma, and still with calcifying odontogenic epithelial tumor (Pindborg tumor) and adenomatoid odontogenic tumor. The authors report a case of COC, starting point for a review of the clinical, radiographic and histomorphologic features of the lesion.
Calcinosis↗
Ameloblastoma ex calcifying odontogenic cyst (dentinogenic ghost cell tumor).
Calcifying odontogenic cyst (COC) has shown to be of extensive diversity in its clinical and histopathological features, as well as in its biological behavior. In this report, a rare case is described of ameloblastoma ex COC (dentinogenic ghost cell tumor) and the relevant literature is briefly reviewed.
Aged↗
Ghost cells in calcifying odontogenic cyst express enamel-related proteins.
The so-called ghost cell is a unique cell type occurring in a variety of odontogenic and non-odontogenic lesions. However, the true nature of ghost cells has not been determined. In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. The cytoplasm of ghost cells in calcifying odontogenic cysts demonstrated distinct immunolocalization of the enamel-related proteins, while similar in the calcifying epitheliomas of the skin showed a negative reaction. The results indicate that the ghost cells in calcifying odontogenic cysts, as opposed to ghost cells in dermal calcifying epitheliomas, contain enamel-related proteins in their cytoplasm accumulated during the process of pathological transformation.
Amelogenin↗
Calcifying odontogenic cysts (keratoameloblatomas).
Two cases of calcifying odontogenic cyst were studied in males over 50. The histopathological diagnosis was based on the presence of ghost cells, partly calcified, in the thickness of the epithelium lining the cyst. These cells contained keratin occurring without keratohyalin granules. We consider that this lesion may be primary or secondary the latter occurring in common odontogenic cysts through the secondary differentiation of epithelial cells.
Humans↗
Calcifying odontogenic cyst presenting as a lateral periodontal cyst--a case report.
We report a case of the calcifying odontogenic cyst occurring on the left anterior mandible of a 41-year-old male with clinical and radiographic features which made it initially to be a lateral periodontal cyst. This unusual presentation of a calcifying odontogenic cyst is discussed and its significance for the clinician is reviewed. A calcifying odontogenic cyst may present some problems for the differential diagnosis both clinically and histopathologically. The differential diagnosis of a lesion occurring in a lateral periodontal location should include the calcifying odontogenic cyst.
Adult↗
Calcifying odontogenic cyst.
The literature pertinent to calcifying odontogenic cysts is reviewed, and an additional case is described. Relevant clinical, radiological and histological features, as well as methods of treatment are considered, and an unusual method of treatment with good results is described in detail.
Aged↗
Radiographic characteristics of the calcifying odontogenic cyst.
4 additional cases of calcifying odontogenic cysts (COC) were reported, together with the radiographic interpretation of 138 cases from the literature. From the review of the literature and of our own cases, the root resorption is one of the most common diagnostic findings as is cystic radiolucency accompanied by radiopacities. Other radiographic characteristics, such as loculation, tooth divergency and bone resorption were emphasized.
Adolescent↗
Ameloblastomatous calcifying odontogenic cyst in the mandible.
Ameloblastoma is one of the well-known odontogenic tumours that can be associated with calcifying odontogenic cysts (COCs), but only a few reports include detailed clinical and radiographic features. In this paper we demonstrate a case of large ameloblastomatous COC in the mandible. The radiographic examination revealed the presence of a multilocular cystic lesion in the right posterior part of the mandible containing the impacted lower second molar with remarkable expansion toward both lingual and buccal side. This feature was different from the general findings of COC and rather resembled that of ameloblastomas.
Adolescent↗
Calcifying odontogenic cyst: report of two cases and review of literature.
The "Histological Typing of Odontogenic Tumours" (W.H.O., 1992) classified the Calcifying Odontogenic Cyst (C.O.C.) into two variants: the non-neoplastic cystic C.O.C. and the odontogenic ghost cell tumour, which is predominantly solid. We reported two cases of C.O.C.: a case with intraosseous development and another with extraosseous localisation, in the soft tissue of the alveolar area. The first case represents a cyst delimited by a squamous, non-keratinized epithelium, thickened in some areas through the accumulation of ghost cells (big pale-staining cells with a non-staining nuclear area). The connective tissue wall contains small ameloblastoma like islands. Dysplastic dentine islands, adjacente to the basal layer of the epithelium or in the connective tissue wall were also observed. The second case was a well-delimitated tumour consisting of ameloblastoma-like islands with numerous ghost cells inside. Islands of dysplastic dentine with psammomathous calcifications also exist. In certain histological sections microcystic aspects surrounded by ghost cells, dentinoid and ameloblastoma-like structures were noticed. The histochemical reaction for keratin and the immunohistochemical reaction for epithelial membrane antigen and for citokeratin were positive for ghost cells, suggesting their epithelial origin. Through this article we try to render pathologists sensitive with a particular and rare maxillary tumour.
Adolescent↗
[Calcifying odontogenic cyst].
Two patients have been described in which a calcifying odontogenic cyst has been removed. One patient concerned a 14-year-old girl with an impacted 24, in which a calcifying odontogenic cyst was removed in connection with a complex odontoma. The other patient concerned a 85-year-old man with a large cyst in the edentulous maxilla, which was marsupialized. This second patient is probably the oldest one reported in the literature concerning calcifying odontogenic cysts. Because of the age of the patient and his general condition, it was felt justified to just marsupialize the lesion instead of a more radical removal. The follow-up findings after one year seem to confirm the justification of the chosen treatment procedure.
Adolescent↗
Characteristics of calcifying odontogenic cyst in Taiwanese.
BACKGROUND AND PURPOSE: Calcifying odontogenic cyst (COC) is a rare type of odontogenic cyst. This retrospective study analyzed the clinical, radiographic, and histopathologic features of COC in Taiwanese. METHODS: Ten cases of COC in 2 male and 8 female patients with a mean age of 29 years (range, 11 to 48 years) treated from January 1985 to December 2002 were included. Microscopic slides, clinical histories, and radiographic features of these 10 COC cases were reviewed and analyzed. RESULTS: COCs occurred in the maxilla in 3 cases and in the mandible in 7 cases. COCs were associated with impacted teeth in 6 cases and with odontomas in 3 cases. All COCs appeared as either unilocular (9 cases) or multilocular (1 case) radiolucencies. In 7 cases, spotty radiopaque materials were scattered throughout the radiolucency. Histologically, all of the lesions were at least partially lined by epithelium with cuboidal to columnar basal cells and stellate reticulum-like suprabasal cells. Variable numbers of ghost cells, some of which were calcified, were observed in the lining epithelium or in the fibrous connective tissue wall of all 10 cases. Juxta-epithelial dentinoid was also found in all cases. However, proliferation of ameloblastoma-like tumor nests was observed in only 1 case. Based on the above histologic findings, 6 COC lesions were classified as simple unicystic type, 3 as unicystic odontoma-producing type, and 1 as unicystic ameloblastomatous proliferating type. CONCLUSIONS: COC occurs frequently in the second and third decades and is commonly associated with an impacted tooth or an odontoma. It usually appears as a mixed radiolucent and radiopaque lesion radiographically. Simple unicystic type is the most common type of COC. No recurrences were found after conservative surgical removal in this series.
Adolescent↗
Aggressive calcifying odontogenic cyst--a possible variant of ameloblastoma.
A case of an aggressive calcifying odontogenic cyst of the maxilla is presented. It recurred twice after surgical excision over the course of a year and was subsequently treated by maxillectomy followed by radiotherapy. The current histological criteria for the diagnosis of calcifying odontogenic cyst were satisfied but it is argued that they are drawn too widely. Since the majority of calcifying odontogenic cysts are benign in behaviour the presence of cytological indicators of local destruction and invasiveness alongside the usual features of calcifying odontogenic cysts (presence of dentinoid, epithelial ghost-cell degeneration) should be the over-riding prognostic considerations and should thus be reflected in the diagnostic title. Such tumours are best regarded as variants of ameloblastoma rather than as unusually aggressive forms of calcifying odontogenic cyst and an appropriate name would be 'dentinogenic ghost-cell ameloblastoma'.
Adult↗