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PubMed1977

Pathogenesis of pemphigus erythematosus.

Immunofluorescence studies were made by the indirect method in 54 cases of pemphigus erythematosus, in 50 of which skin specimens from light-exposed and unexposed regions were investigated also by the direct IF method. IF Band was shown to be demonstrable in skin specimens from exposed regions in 81% of cases and from unexposed regions in 23%. ANA were found in some 31% of patients, though usually in titers below those of IC antibodies. There were 2 cases each of coexistence with myastenia gravis and thymoma and with SLE. Virus-like particles, however, were found by electron microscopy only in 1 case with coexisting SLE. Detection of IF Band in skin specimens from a significant majority of patients with pemphigus erythematosus, presence of ANA in some, and occasional coexistence of SLE suggest some relation of the disease with lupus erythematosus.

Adult↗
PubMed1980

Pemphigus erythematosus and thymoma.

A sixty year old woman was found to have a benign thymoma and pemphigus erythematosus. Her skin disease was controlled with oral and topical corticosteroids. The association between thymoma and pemphigus erythematosus is discussed, and the literature reviewed. Most previous cases have also had myasthenia gravis and skeletal muscle antibodies. This is the first case in which neither of these was present.

Adrenal Cortex Hormones↗
PubMed2003

Pemphigus erythematosus associated with anti-DNA antibodies and multiple anti-ENA antibodies: a case report.

Pemphigus erythematosus (PE) is an autoimmune blistering disease combining features of pemphigus foliaceus (PF) and systemic lupus erythematosus (SLE). We report a case of PE associated with anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro (anti-SSA), and antiribonucleoprotein (anti-RNP) antibodies. This case required extensive immunosuppressive therapy. We treated our patient with a combination of systemic steroids, intramuscular gold injections, azathioprine, and hydroxychloroquine. The patient's response was complete remission--evaluated clinically, serologically, and immunohistochemically.

Adult↗
PubMed1991

The role of cyclosporine A in the treatment of pemphigus erythematosus.

Steroids are effective in the autoimmune bullous disease pemphigus; however, treatment may be difficult to sustain because of severe side effects. Cyclosporine A acts mainly on helper/inducer T lymphocytes and has few side effects at low doses. We report three patients with pemphigus erythematosus who had a relapse while receiving the maintenance dose of steroid therapy. All patients who were treated with both cyclosporine A (5 mg/kg/d) and prednisone (1 mg/kg/d) responded remarkably well to combined therapy. After clearing, prednisone was discontinued and cyclosporine A was reduced to 2 to 3 mg/kg/d. With this treatment, all patients have been virtually free of symptoms, have remained well, and have had normal laboratory values.

Adult↗
PubMed1987

[Pemphigus erythematosus--detection of anti-DNA antibodies].

In an 80-year-old woman with pemphigus erythematosus, we demonstrated ANA as well as anti-DNA antibodies in the serum. This finding supports the argument that this skin disorder represents a combination of a disease of the pemphigus group with systemic lupus erythematosus.

Aged↗
PubMed1986

[Cyclosporin A in the treatment of pemphigus foliaceus and pemphigus erythematosus].

We present the cases of two female patients with pemphigus foliaceus and pemphigus erythematosus, respectively, who did not respond to long-term azathioprine and prednisone treatment in high dosages. In both patients the skin condition improved nearly completely after therapy with cyclosporine A (3.5-6.5 mg/kg per day) in combination with prednisone (7.5-10 mg every 2 days). We did not observe any side-effects during 1 year of this therapy.

Complement C3↗
PubMed1984

Pemphigus erythematosus: clinical and histo-immunological studies in two unusual cases.

In two unusual cases of pemphigus, classified as pemphigus erythematosus (PE), the clinical and laboratory data are summarized and discussed. In case I, with characteristic immunologic features of PE, acantholysis was detectable only by the EM-technique. Case II with transitory pemphigus and features of SLE was diagnosed as "probable PE". In this case (case II) concomitant incidence was found of benign thymoma. In addition in both cases the patterns of T-cells and T-cell-subsets in blood and lesional skin are briefly discussed.

Aged↗
PubMed1999

Pemphigus erythematosus associated with thymoma: a case report.

A 52-year-old Chinese man was found to have a benign thymoma and pemphigus erythematosus (PE). Initially, most of his skin lesions appeared on the scars of the surgical incisions and suture sites three months after he underwent thymectomy. To our knowledge, this is the first report documenting the skin lesions of PE on the scars after thymectomy. Most of the previous cases had myasthenia gravis and skeletal muscle antibodies. However, in this patient, neither condition was present.

Cicatrix↗
PubMed2005

Pemphigus erythematosus in a chow chow.

A 3.5-year-old, spayed female, chow chow presented with a pruritic, ulcerative, butterfly lesion on the nasal planum, typical of the pemphigus complex. Pemphigus erythematosus was diagnosed by histopathologic examination. Treatment consisted of enrofloxacin and immunosuppressive therapy with prednisone and azathioprine. Within 5 wk of treatment, the lesions had resolved almost completely.

Animals↗
PubMed1979

Two cases of penicillamine-induced pemphigus erythematosus.

2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1 1/2 years, respectively, with penicillamine. Both developed a bullous eruption which according to clinical and histological picture, immunofluorescence studies and to light provocation, as well as in 1 case to antinuclear antibody findings corresponded to pemphigus erythematosus. In spite of treatment with prednisone and azathioprine, they still keep developing bullae.

Aged↗