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Results for “PLASTER OF PARIS”

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PubMed1983

[Plaster of Paris pellets containing antibiotics in the treatment of bone infection. New combinations of plaster with antibiotics].

The author has tested the action of antibiotic-loaded plaster of Paris loaded pellets in 15 patients with success in 13. Previous studies using plaster of Paris for filling bone defects are noted, plaster being well tolerated and absorbable. Gentamycin, Fucidin and Cefazolin were tested first. In a second series, Netilmicin, Amikacin, Rifamycin and Rifampicin were also used. The preparation of the pellets is fully described. In most instances they can be sterilized by gamma rays except for Fucidin and Cefazolin. Several hundred pellets can be used simultaneously. A study of the elimination of antibiotic in the urine was made. It was concluded that the concentrations obtained by this method in the tissues were highly satisfactory.

Amikacin↗

PubMed1980

New casting material and improved functional design for lower femoral fracture bracing.

A new water setting light plastic plaster material, Crystona, is presented and its plaster room characteristics compared with plaster of Paris. Plaster of Paris is considered better as the "acute fracture splinting material" in the Accident Service setting. Crystona, however, has considerable advantages as the "dynamic bracing material" in the post-acute fracture period and is demonstrated in the functional bracing of femoral shaft fractures. An improved functional cast brace design is presented, the "Knee Hinge Cylinder Brace" with a simple waist belt suspension to a hinged tube cast without the foot in the treatment of distal half femoral fractures. Using Crystona and the cylinder brace design, the cast weight has been reduced by half and the functional limb bracing improved with free mobilization of the knee, ankle and foot. The prescription, application technique and early clinical experiences are presented.

Acrylic Resins↗

PubMed1981

Plaster of paris as an alloplastic implant in the frontal sinus.

The use of calcium sulfate (plaster of Paris) has been advocated to repair bony defects because of its unique capability of stimulating osteoneogenesis. Plaster of Paris can be used as a bony alloplast, and it can be analyzed histologically. Sinus roentgenograms and technetium Tc 99m medronate bone scanning further support the use of plaster of Paris as an alloplast and assess its osteoneogenic capacity when implanted in the frontal sinus of dogs; complete bone regeneration was demonstrated in six dogs within four to six months. The use of plaster of Paris for bone reconstruction in the head and neck can be applied in surgery. The experience with plaster of Paris to date, although limited, shows it to be safe and highly encouraging as an effective bone allograft.

Animals↗

PubMedDate not supplied

Plaster of Paris: the forgotten hand splinting material.

This article examines the concept of tissue adaptation in response to the application of plaster of Paris splints and casts. A review of the history of plaster of Paris and its composition, its working properties, and precautions for its use introduces the reader to this oft-forgotten material. Four designs are described for plaster of Paris application-circumferential padded casts, digital unpadded casts, plaster slabs, and contour molds. The discussion of clinical application of plaster of Paris covers joint tightness, arthritis, contracted joints due to spasticity, muscle-tendon tightness, skin tightness, skin and joint tightness, and edema reduction. In addition, a new application called casting motion to mobilize stiffness (CMMS), developed by the author, is discussed. The use of plaster of Paris to improve postoperative flexor tendon glide is also discussed. This review article intends to stimulate the reader to use plaster of Paris splinting or casting more frequently to solve clinical problems.

Calcium Sulfate↗

PubMed1992

Antibiotic-impregnated plaster of Paris beads. Trials with teicoplanin.

Teicoplanin-impregnated plaster of Paris beads were made and in vitro release properties were studied. Teicoplanin was released in an initial massive dose, with a rapid decline during the first three days, followed by a slowly declining prolonged release up to 30 days. The release tested by diffusion in gelose and high-performance liquid chromatography was found to be 21.4% and 28.2%, respectively, of the amount theoretically present in the beads. Plaster of Paris is a resorbable, nontoxic biomaterial that has already been used to fill dead spaces in bone and deliver antibiotics in the treatment of chronic osteomyelitis. The addition of teicoplanin, a new antistaphylococcal agent with low known bacterial resistance, is a promising alternative. Follow-up tests in vivo, simulating local conditions of the osteomyelitic bone, are necessary to prove efficacy.

Anti-Bacterial Agents↗

PubMedDate not supplied

Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants.

PURPOSE: To evaluate the effect of particulate dentin-plaster of Paris with and without platelet-rich plasma (PRP) on bone healing and new bone formation around titanium dental implants in a canine model. Histologic sections and histomorphometric analysis of the defects were obtained at 6 and 12 weeks after surgery. MATERIALS AND METHODS: Three circular bone defects were surgically prepared in iliac crest sites in each of 10 animals. A total of 30 Avana dental implants were placed in the animals. They were self-tapping, screw-type implants, 10 mm in length and 4 mm in diameter, all made of commercially pure titanium. A titanium implant was placed centrally in each defect. In each dog, the defects were treated with 1 of the following 3 treatment modalities: (1) no treatment (control); (2) grafting with particulate dentin-plaster of Paris; (3) grafting with particulate dentin-plaster of Paris and PRP. RESULTS: Histologic analysis showed that all of the bone defects surrounding the implants that were treated with particulate dentin-plaster of Paris, with and without PRP, were filled with new bone. The defects that were not treated (control) demonstrated new bone formation only in the inferior threaded portion of the implants. DISCUSSION: Histomorphometric results revealed a higher percentage of bone contact with particulate dentin-plaster of Paris and PRP compared to the control and particulate dentin-plaster of Paris. CONCLUSIONS: These results suggested that bone defects around titanium implants can be treated successfully with particulate dentin-plaster of Paris, and that the outcome can be improved if PRP is also used.

Analysis of Variance↗

PubMed1993

[Plaster of Paris: a carrier for antibiotics in the treatment of bone infections].

Local antibiotherapy by diffusion from plaster of Paris is a promising method in orthopedic surgery. Nevertheless, the characteristics of this matrix have not yet been extensively studied with respect to regulation of drug-carrier capacity. From the careful comparative investigation of five commercialized plasters of Paris, it appears that the material must be constituted of fine homogeneous crystals devoid of any additive in order to obtain reproducible implants which are sufficiently hard. This condition determines their use as a biodegradable filler of bone cavities. Because of the antimicrobial spectrum, diffusion velocity and synergistic effect of sodium fusidate, amoxicillin trihydrate and sodium amoxicillin, this association of antibiotics with the plaster of Paris appears to be a useful sterilizing delivery system. The plaster of Paris allows a significant release of sodium amoxicillin during the first 3 days. This is followed by an important sustained liberation of sodium fusidate and amoxicillin trihydrate for one week. Finally, the local release of sodium fusidate for at least 2 weeks at concentrations higher than the minimum inhibition concentrations (MIC) of the most frequently infecting pathogens in osteomyelitis, will allow the sterilization of bone cavities.

Anti-Bacterial Agents↗

PubMed1986

Hexcelite versus plaster of Paris: a controlled trial of the below-knee walking cast.

Hexcelite and plaster of Paris below-knee walking casts were compared in a controlled clinical trial, involving 82 patients. Fewer bandage complications, problems and better comfort was found with Hexcelite compared to plaster of Paris (P less than 0.05). If all costs relating to materials, transportation, complications and extra visits due to these, were taken into account, plaster of Paris was found more expensive than Hexcelite. Based on the above an increased use of Hexcelite is recommended.

Adolescent↗

PubMed1994

An in vitro evaluation of plaster of Paris barriers used under amalgam and glass ionomer to repair furcation perforations.

Furcation perforations were created in the pulpal floor of 60 teeth and were repaired with amalgam alone, plaster of Paris under amalgam, light-cured glass ionomer alone, and plaster of Paris under light-cured glass ionomer. After the access openings were filled with composite resin, the teeth were immersed in 2% erythrocin B dye solution for 2 wk, sectioned longitudinally, and dye penetration was measured. The light-cured glass ionomer group provided the least amount of leakage, followed by the group of plaster of Paris under glass ionomer. The groups using amalgam alone and plaster of Paris under amalgam showed the most leakage. The plaster of Paris barrier prevented the overextension of the repair materials when used under amalgam and glass ionomer.

Analysis of Variance↗

PubMedDate not supplied

The effects of plaster of Paris and autogenous cancellous bone on the healing of cortical defects in the femurs of dogs.

Four one quarter inch evenly spaced circular defects were created bilaterally in the lateral femoral diaphysis of 12 clinically normal adult dogs. The defects were left unfilled (control), or were filled with one of the following: (1) plaster of Paris, (2) an equal-volume mixture of plaster of Paris and autogenous cancellous bone, and (3) autogenous cancellous bone. The degree of bone healing was evaluated radiographically and histologically at 2, 4, 6, 8, 10, and 12 weeks. Radiographically, no objective conclusions could be drawn due to the small size of the defects and limited amount of plaster of Paris implanted. Histologically, there was no inflammatory reaction to the plaster of Paris. No differences were determined in the degree of bone healing between autogenous cancellous bone, plaster of Paris, and a mixture of plaster of Paris and autogenous cancellous bone. All implants were superior to the control defect in degree of bone healing.

Animals↗

PubMed1982

Antibiotic loaded plaster of Paris pellets: an in vitro study of a possible method of local antibiotic therapy in bone infection.

Plaster of Paris is an effective ancillary treatment in the surgery of infected cavities in bone. It is well tolerated and spontaneously absorbed over a period of weeks to months, being replaced by bone of normal architecture. It effectively obliterates much of the dead space, leaving little room for hematoma formation. It would appear logical to treat local infection, especially involving rigid walled cavities, by a locally diffused antibiotic. When incorporated into plaster of Paris pellets, two antibiotics, Fucidin and gentamicin, are capable of prolonged local release in bacteriocidal concentrations. On the basis of in vitro observations on bacterial cultures, it is proposed that antibiotic-plaster of Paris pellets might be a simple adjuvant technique to good surgical debridement in the treatment of bone infection. Plaster of Paris has the practical advantage over acrylic cement beads containing antibiotics in that it is resorbed and would not need a subsequent operation to be moved.

Anti-Bacterial Agents↗

PubMed2000

Plaster of Paris as an osteoconductive material for interbody vertebral fusion in mature sheep.

STUDY DESIGN: In adult female sheep, histologic and biomechanical criteria were used to determine whether the osteoconductive performance of plaster of paris would promote the incorporation of the tubular titanium mesh implants used for interbody vertebral fusions. OBJECTIVES: To compare the osteogenicity of plaster of paris with that of autogenous iliac crest bone and bone marrow 6 months after they were loaded into tubular titanium mesh cages and implanted as L3-L5 bridges after L4 corpectomies. SUMMARY OF BACKGROUND DATA: One of the aims of surgery for vertebral pathology is to stabilize the spine by interbody fusions. The morbidity associated with the use of iliac crest autograft bone for fusion grafts prompted trials using plaster of paris as an osteoconductive substrate. METHODS: The total volume of bone that invested the L3-L5 mesh cages after 6 months was quantitated by computed tomography scans. All specimens subsequently were cut into fusion mass segments for biomechanical testing in flexion, extension, compression, and torsion, and then embedded in plastic for sectioning and histomorphometry to determine the trabecular bone volume within the titanium mesh. RESULTS: In each experimental model, implants of plaster of paris were the osteoconductive equal of autogenous iliac crest bone/marrow preparations. The volumes of bone formed around and within the titanium mesh were identical, and the tissues were biomechanically indistinguishable. A partial mechanism was determined by modifying the system for midshaft femoral defects. CONCLUSIONS: In the sheep, a tubular titanium mesh packed with plaster of paris forms an osteoconductive conduit to achieve a biomechanically stable interbody lumbar vertebral fusion.

Animals↗

PubMed1992

A clinical evaluation of plaster-of-Paris and eight synthetic fracture splinting materials.

A number of new synthetic orthopaedic splinting materials, all claiming substantial advantages over the traditional plaster-of-Paris, have been introduced in recent years. However, although their properties have been extensively measured in the laboratory, little has been documented concerning their performance in clinical use. This study was therefore initiated as a comparative evaluation of the clinical characteristics and ease of use of these relatively expensive materials in the fabrication of below-knee weight-bearing casts. The study encompassed nine materials--seven based on water-activated polyurethanes, one thermoplastic and plaster-of-Paris, and involved a total of 203 patients. It was concluded that plaster-of-Paris should be used for all routine splinting applications, but that in cases in which cast weight, cast bulk, or the time to bearing weight is important, a synthetic material, chosen principally on the basis of cost, is indicated.

Adolescent↗

PubMed1998

Osteogenic response of rabbit tibia to hydroxyapatite particle-Plaster of Paris mixture.

A mixture of hydroxyapatite (HA) particles and plaster of Paris (POP) with saline solution was injected into the bone marrow of 30 unilateral tibiae of 30 rabbits. As a control, POP with saline solution was similarly injected into the bone marrow of 30 unilateral tibiae of 30 additional rabbits. Five rabbits in each group were killed 2, 4, 8, 12, 24 and 40 weeks after injection. Histological examination was performed on three tibiae of five killed animals, and X-ray diffraction analysis of the bone marrow was performed on the remaining two tibiae. In two of three tibiae, bridges of new bone were formed between the hydroxyapatite particles and the cortical bone, 4 weeks after the injection of the HA particle-POP mixture. New bone formation was seen in all three tibiae at 8 weeks and thereafter. No new bone formation was observed in the tibiae of the control group. The affinity index, a parameter of osteogenesis, was 0% at 2 weeks, 52.2+/-14.0% at 4 weeks, 74.8+/-5.3% at 8 weeks, 86.1+/-6.1% at 12 weeks, 90.1+/-8.3% at 24 weeks and 92.8+/-4.1% at 40 weeks after injection. Statistically significant increases were found between the affinity indexes of 2 weeks and 4 weeks and between those of 4 weeks and 8 weeks, p < 0.03 and p < 0.05, respectively. Between 12, 24 and 40 weeks, the indexes showed tendencies toward increases. X-ray diffraction of bone marrow of two tibiae into which HA particle-POP mixture or POP alone was injected showed that POP had disappeared 8 weeks after injection.

Animals↗

PubMed1982

Heat generation in plaster-of-Paris and resulting hand burns.

Four female pupils at a technical school received hand burns while trying to make moulds of their hands using a dental plaster instead of ordinary plaster-of-Paris. In three cases the burns were so severe that several fingers had to be amputated due to irreversible tissue damage. The severity of the burns is explained on the basis of an experimental study where it was demonstrated that the temperature of hardening dental plaster rose to 70 degrees C and had a hardness that was 10-times greater than ordinary plaster-of-Paris. This should serve as a warning against the use of dental plaster in direct casting of living tissue. However, the technique used here is also considered dangerous, as ordinary plaster-of-Paris under certain circumstances could also cause severe burns.

Adolescent↗

PubMed1999

An evaluation of plaster of Paris barriers used under various materials to repair furcation perforations (in vitro study).

The present study was undertaken to evaluate the effect of plaster of Paris barriers on the sealing ability of various materials when used to repair furcation perforations. The study was conducted on 90 human permanent molars with well developed, nonfused roots. Access openings and furcation perforations were prepared in the pulp chamber floor. The teeth were divided into one control and five experimental groups of 15 teeth each. In the experimental group, plaster of Paris barriers were created in the perforations and then sealed with silver amalgam, glass ionomer (GI), self-cured composite resin, IRM, or AH26. Access openings were filled with composite resin. The teeth were submerged in a solution of 2% methylene blue dye for 2 wk. Finally, the samples were sectioned and evaluated for linear dye leakage and analyzed statistically. Maximum dye penetration was observed in amalgam followed in a decreasing order by GI, composite, IRM, and AH26. AH26 showed the best sealing ability in the presence of plaster of Paris barriers followed by IRM, composite resin, and GI. Amalgam showed the poorest sealing ability when used to repair furcation perforations.

Analysis of Variance↗

PubMed1987

Gentamicin-loaded plaster of Paris as a treatment of experimental osteomyelitis in rabbits.

In this study, implantation of gentamicin-loaded plaster of paris after a debridement of the marrow cavity was tested in rabbits with established Staphylococcal osteomyelitis. The animals were observed for clinical and roentgenographic signs of infection after killing. The infections were evaluated by bone cultures and antibiotic levels. The implanted antibiotics alone resulted in only two of ten culture-proven cures. However, clinical and roentgenographic data showed overall improvement in the treated group as compared to controls. A valuable feature of gentamicin-loaded plaster of paris, warranting further investigation, is the elimination of dead space while the antibiotic is locally absorbed by the tissue fluids.

Animals↗

PubMed2002

Hydroxyapatite/calcium carbonate (HA/CC) vs. plaster of Paris: a histomorphometric and radiographic study in a rabbit tibial defect model.

The search for an ideal bone substitute is ongoing. Multiple osteoconductive bone substitutes are available today. Plaster of Paris (POP) (calcium sulfate) has been used for more than 100 years for treatment of skeletal defects. This implant is compared to a new material, hydroxyapatite/calcium carbonate (HA/CC), in a rabbit tibia model. HA/CC is made from partial conversion of coralline calcium carbonate to hydroxyapatite and has an outer hydroxyapatite layer and an inner calcium carbonate core, a combination that leads to faster resorption than that of pure hydroxyapatite. This study compares the histomorphometric and radiographic properties of POP and HA/CC in a rabbit tibial defect. Both implants preferentially restore bone to the cortex relative to the canal. Plaster of Paris was fully resorbed by 6 weeks both radiographically and histometrically and HA/CC was substantially resorbed by 42 weeks. No significant difference was noted in volume fraction of bone between the two implants at 42 weeks postimplantation. Hydroxyapatite/calcium carbonate is a biocompatible bone graft substitute with a rate of resorption significantly slower than plaster of Paris.

Animals↗