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Acute gestational cocaine exposure alone or in combination with low-dose ethanol does not influence prenatal mortality or fetal weight in mice.

The teratogenic effects of cocaine and ethanol were investigated using an acute treatment model of C57BL/6J mice treated on gestation day 15 (GD15) with evaluation on GD17. Females were intubated once with a subteratogenic dose of ethanol (0 or 4 g/kg) and injected subcutaneously twice, 1 h apart, with equal doses of cocaine HCl (0 or 60 mg/kg), for a final daily dose of 120 mg/kg. The first cocaine injection followed ethanol by 10 min. Blood ethanol levels (BEL) and plasma cocaine levels were determined, and pair-feeding was employed. The results revealed no group differences on pregnancy outcome. That is, maternal weight gain, total number of implants, prenatal mortality, and fetal body weight were not statistically different. No significant differences in BEL or plasma cocaine levels were found among the various treatment groups. These results suggest that, under these conditions, relatively high levels of cocaine (120 mg/kg, SC), given alone or in combination with subteratogenic doses of ethanol late in pregnancy, are not teratogenic in mice.

Animals↗
PubMed1992

Prenatal influence of alcohol following a single exposure in two inbred strains of mice.

The effect of a single dose of ethanol on embryonic development was investigated in two inbred strains of mice. Ethanol (25% v/v solution, 0.02 ml/g body weight) was administered intraperitoneally on either gestational day 6, 9 or 12 to C57BL/6J and DBA/2J mice. All fetuses recovered near term were alive and appeared normal. The incidence of fetal death was not affected. Fetal weight was significantly reduced in the C57BL/6J strain of mice. Maternal exposure to a single and moderate dose of ethanol did not have any profound effect on the conceptus. For the development of laboratory models to mimic fetal alcohol effects in humans, the selection of appropriate genotype is important.

Animals↗
PubMed1962

Prenatal influence on behavior of offspring of crowded mice.

Pregnant albino mice were subjected to stress by crowding. When the litters encountered unfamiliar stimuli, they were less active, they were slower to respond, and they defecated less than control mice. These differences persisted at 30 and 100 days of age, whether the mice were raised by a crowded or by an uncrowded mother, and in spite of starvation. One explanation may be that aberrant endocrine activity in the crowded, pregnant female impairs the development of fetal response systems.

Animals↗