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At least 37 records · Page 2Linked to original sources
PubMed1979

Isolation and identification of mycobacteria from cattle slaughtered in Pakistan.

Specimens of lung, liver and mesenteric lymph node from cows and buffaloes slaughtered in the Lahore area were cultured to investigate the type of mycobacteria involved in bovine tuberculosis. Employing the concentration method, 56 out of 530 cattle were found to be culture positive for acid-fast bacteria, 48 being Mycobacterium bovis and eight atypical mycobacteria. No M tuberculosis or M avium was isolated. Most of the isolated M bovis strains were found to be highly virulent for rabbits.

Animals↗
PubMed2025

BRCA1 Exon 11 Mutations in Breast Cancer: A Study From Pakistan.

Breast cancer ranks among the top causes of cancer-related deaths in women around the globe, with genetic mutations in the BRCA1 gene being a frequent cause of breast or ovarian cancer. This study investigates hotspot mutations in exon 11 of the BRCA1 gene among Pakistani women diagnosed with breast cancer. Thirty clinically diagnosed breast cancer patients, all women, were enrolled in the current study, and high-quality DNA was extracted from peripheral blood samples. Two of the twenty-five successfully sequenced samples had a homozygous missense variant (c.2312T > C: p.Leu771Ser) detected by Sanger sequencing after PCR amplification. Upon investigation in the ClinVar database, the identified variant showed conflicting interpretations of pathogenicity. Demographic data highlighted an early disease onset, showing that 56% of patients were under 50 years of age. The need for genetic screening was further supported by the fact that 24% of the patients had a positive family history of cancer. Our study emphasizes the necessity of screening BRCA1 gene mutations to better understand the pathogenic potential of the identified variants in the Pakistani population.

Humans↗
PubMedDate not supplied

Opium use in two communities of Pakistan ---a preliminary comparison of rural and urban patterns.

Interviews were conducted to clarify drug use patterns and characteristics of opium users in two communities. Because of the small number of subjects selected from only two communities, the results are not representative of the country as a whole. Nevertheless, in the city of Rawalpindi 90 users were studied and found to have a mean daily opium consumption of 0.9 grams at a cost of Rs. 1.00 ($US 0.10). Opium was taken by mouth once or twice daily. They were solitary users who first used opium as adults, most often for self-treatment of health disorders. The majority were employed males with no history of criminality. In the rural opium-producing village, 28 users were interviewed. They smoked opium three or four times a day in a social setting and reported a mean daily consumption of 11 grams. They were more likely to use the drug for its social and pleasure effects and to have addicts as close friends. The high dose was associated with adverse effects on work performance and with more severe withdrawal symptoms. The findings suggest different intervention strategies for the two populations.

Adult↗
PubMed1978

A quantitative mosquito survey of 7 villages in Punjab Province, Pakistan with notes on bionomics, sampling methodology and the effects of insecticides.

A total of 451,337 female and male mosquitoes comprising 43 species in 9 genera were collected during a quantitative survey of 7 suburban and rural villages in the Lahore area during 1976 and 1977 using larval, indoor resting, outdoor resting, biting and light trap collections at weekly intervals. Culex tritaeniorhynchus was the most abundant species collected comprising 51.8% of the total specimens, followed by Cx. quinquefasciatus (16.4%), Cx. pseudovishnui (6.8%), An. subpictus (4.8%) and An. culicifacies (4.7%). Bovid bait collections provided the greatest diversity and highest numbers of mosquitoes per unit of collection effort, while light traps provided the poorest diversity and lowest numbers of specimens. Most species exhibited a bimodal seasonal abundance pattern, with peaks occurring in late spring and after the cessation of the heavy monsoon rains. The spraying of houses and cattle sheds with organophosphorous insecticides was effective in controlling the endophilic resting vectors of human Plasmodia, An. culicifacies and An. stephensi, but had little effect on the partially or completely exophilic resting species.

Culicidae↗