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At least 37 records · Page 2Linked to original sources
PubMed1982

Electrochemical properties of polycyclic compounds studied by the polarographic method in anhydrous systems. VIII. The influence of proton-donor on reduction of carcinogenic nitrogen compounds in dimethylformamide.

The authors have studied the electrochemical behavior of a series of carcinogenic and inactive heterocyclic compounds in anhydrous medium in the presence of a proton-donor. As anhydrous medium the authors used anhydrous dimethylformamide as proton-donor phenol. In the presence of proton-donor there had occurred on polarographic reduction of the employed carcinogenic heterocyclic compounds changes in the number of polarographic waves. Between the two original waves in these compounds there arose in the presence of phenol a new wave. In non-carcinogenic heterocyclic compounds such an effect of phenol was not noted. In the present paper the authors discuss the possible mechanism of electroreduction of carcinogenic and inactive heterocyclic compounds in anhydrous medium in the presence of a proton-donor.

Aza Compounds↗
PubMed2005

[DNA adducts as biological markers for human exposure to polycyclic aromatic compounds].

Polycyclic Aromatic Hydrocarbons (PAH) in human carcinogenesis is undisputed. Measurements of PAH-DNA adduct levels in easily accessible white blood cells therefore represent useful early endpoints in exposure intervention or preventive study. The successful applicability of DNA adducts as early endpoints depends on several criteria: (1) Adduct levels in easily accessible surrogate tissues should reflect adduct levels in target tissues (2) Toxic-kinetics and the temporal relevance should be properly defined (3) Sources of inter and intra individual variability must be know and controllable (4) Adduct analysis must have advantages as compared to other markers of PAH exposure. Higher proportions of subjects with detectable DNA adduct levels were found in exposed individuals as compared with non-exposed subjects, but saturation may occur at high exposure. Furthermore, DNA adducts levels varied according to changes in exposure. Intra-individual variation during continuous exposure was low over a short period of time (weeks), but varied significantly when longer time periods (months) were investigated. Intra-individual variation is currently only partly explained by genetic polymorphisms in genes involved in PAH metabolism. DNA adducts measurements have three advantages over traditional exposure assessment: (1) they can smooth the extreme variability in exposure which is typical for environmental toxicants and may integrate exposure over longer periods of time (2) Biological monitoring of DNA adducts accounts for all exposure routes (3) DNA adduct may account for inter-individual differences in uptake, elimination, distribution, metabolism and repair amongst exposed individuals. There is a sufficiently large scientific basis to justify the application of DNA adduct measurements as biomarkers in exposure assessment. However, their use in risk assessment requires further investigation.

Biological Transport↗
PubMed2004

Reactions of Diels-Alder adducts of a sugar-derived dihydropyranone leading to fused polycyclic compounds.

Manipulation of the ketone and alkene functions of cycloadducts 2, 3, and 4, derived from optically active (ee >86%) (S)-2-benzyl-2H-pyran-3(6H)-one (1), led to polycyclic systems having three or four fused rings. Reduction of the carbonyl group of the butadiene adduct (2) took place with low facial selectivity affording the alcohols 5 and 6 in 1:1.4 ratio. In contrast, a higher diastereoselection was observed for the reduction of the carbonyl of the cyclopentadiene adducts 3 and 4 to give the endo alcohols 10 and 13, respectively. The epoxidation of 6 showed low facial selectivity in the formation 7 and 8, whereas epoxidation of 10 and 13 took place from the exo face of the norbornene system to give spontaneously the polycyclic alcohols 11 and 14 by opening of the epoxide by intramolecular attack of the hydroxyl group of the pyranoid ring. Similarly, addition of iodine to 10 led to the polycyclic iodide 12.

Alcohols↗
PubMed2001

Volatile organic compounds, polycyclic aromatic hydrocarbons and elements in the air of ten urban homes.

Ten homes were monitored at regular intervals from June 1994 through April 1995 as part of a Public Health Assessment in Southeast Chicago for exposure to volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), and elements. Simultaneous 24-h indoor and outdoor samples were collected. VOCs were and analyzed using USEPA Method TO-14 with Selected Ion Monitoring Mass Spectrometry (GC/MS). PAHs were analyzed using USEPA Method TO-13 with GC/MS. Elements were collected on quartz fiber filters and analyzed by Inductively Coupled Argon Plasma (ICP) spectroscopy or Graphite Furnace Atomic Absorption (GFAA). Continuous measurements of CO2 and temperature were recorded for each indoor sample. Twenty-four h total CO2 emissions were determined from occupancy and estimated gas stove usage and were moderately correlated (R2 = 0.19) with 24 h average indoor CO2 concentrations. Modeled 24-h air exchange rates ranged from 0.04 to 3.76 air changes h-1 (ACH), with mean of 0.52 ACH. Median particle penetration was 0.89. Emission rates were calculated for each pollutant sampled. Using a detailed housing survey and field sampling questionnaires, it was possible to evaluate associations between housing characteristics and source activities, and pollutant source rates. The data indicate that several predictor variables, including mothball storage, air freshner use, and cooking activities, are reasonable predictors for emission rates for specific pollutants in the homes studied.

Air Movements↗