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Results for “Post-Concussion Syndrome”

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PubMed1975

[Trial of a new therapeutic agent, Pervincamine, in the post-concussion syndrome of patients with head injuries. Application of a double-blind control system and sequential analysis].

The authors have studied the influence of Pervincamine on the postconcussional syndrome in a group of 30 patients with cranial trauma examined for at least six months after their accident. The double blind testing was utilised and the patients were followed at regular intervals spanning three weeks. Each patient was evaluated by semi-directed interviews and tests of "double barrage" of Zazzo and the 15 words test of Rey. In addition, an EEG was performed at the beginning and the end of the study. Statistical analysis of the evolution of symptoms and the results obtained by psychological testing has revealed the positive action of Pervincamine on the postconcussional syndrome and on mental as well as motor functioning in general. Furthermore, the secondary effects of this product are negligible.

Adolescent↗
PubMed1978

[Therapeutic trial of tiapride in ENT].

Tiapride was studied in 60 patients with ENT affections. The dosage was 1 to 2 ampoules IM a day for 7 to 10 days, followed by a half a tablet 3 to 4 times a day for 2 weeks to 2 months. Results were excellent or good for 16 out of 20 cases of essential headache, 6 out of 6 cases of Barré Liéou's syndrome, 7 out 8 cases of sinus pain, 6 out of 8 cases of Méniè's disease, and 6 out of 6 cases of facial paralysis "a frigore". In 7 cases of post-concussion syndrome, excellent results were observed in all the patients, on headache. Vertigo was reduced in intensity. The effects was moderate or nil on tinnitus and deafness due to Ménières syndrome, as well as in 2 casls of facial neuralgia. Tolorance was excellent as, in these 60 patients, only 2 cases of dry mouth and 1 case of vomiting in a diabetic were reported.

Adolescent↗
PubMed1987

Neurologic aspects of boxing.

The assessment and prevention of potentially adverse neurologic consequences of boxing requires two important considerations. Acute neurologic injuries should be distinguished from chronic brain injuries and the level of competitive boxing (ie, amateur vs professional) must also be taken into account. Acute neurologic injuries such as concussion, post-concussion syndrome, intracranial hemorrhage, and brain contusion are more readily identified than chronic neurologic injuries because of their immediate devastation of the nervous system. In contrast, chronic neurologic injuries differ in their pathophysiologic mechanisms that are exemplified by an insidious onset and progression after the cessation of boxing. Accordingly, the chronic traumatic encephalopathy of boxing poses the most serious neurologic threat of boxing. Amateur boxing differs from professional boxing in the duration of fights, rules and regulatory policies, medical evaluation, and protective devices. These factors could produce a differential effect on the risk of injury to the brain. The prevention of neurologic injuries in boxing requires the integration of proper neurologic evaluation by qualified ring-side physicians, the design and utilization of effective protective devices, and the establishment of national regulatory agencies.

Athletic Injuries↗
PubMed2026

Investigating genetic susceptibility to concussion through rare variants in ion channel and neurotransmission genes.

Some individuals appear more susceptible to concussion or mild traumatic brain injury (mTBI) and the severity, range, and the persistence of post-concussion symptoms vary considerably between affected individuals. Genetic factors are likely to contribute to this variability. Symptomatic overlap of post-concussion syndrome with neurological conditions such as familial hemiplegic migraine (FHM) caused by rare pathogenic variants in ion channel and synapse protein genes, with high sensitivity to head trauma for some patients, suggests that variation in similar pathways may influence concussion susceptibility and recovery. To investigate this hypothesis, we performed whole exome sequencing in 93 unrelated individuals who had sustained a single or multiple concussions and examined rare protein-altering variants in FHM genes, other neuronal ion channel and transporter genes, and genes involved in neurotransmission. We identified 62 different rare missense variants across 24 genes in 59 participants (63%), with 26 individuals carrying 2 or more variants. The prevalence of specific likely damaging rare variants in the 16 ion channel-related genes that were identified was approximately fivefold higher than that observed from gnomAD population controls (Odds Ratio = 5.44, 95% CI [4.13,7.18], P < 0.0001). Notably, voltage-gated calcium and sodium channel genes, including SCN9A, together with neurotransmission-related genes such as SNCAIP, harboured multiple potentially deleterious variants. These findings suggest that rare deleterious variants in genes involved in ion homeostasis and neurotransmission may contribute to an individual's susceptibility to concussion or more severe post-concussion symptoms. This study provides a foundation for future genetic and functional investigations aimed at improving our understanding of concussion susceptibility and outcomes. Further validation in larger cohorts and mechanistic studies is warranted to determine their utility as biomarkers of concussion risk and prognosis.

Humans↗
PubMed1982

Epidural hematoma: report of seven cases with delayed evolution of symptoms.

Epidural hematomas occasionally have a prolonged clinical course with gradual evolution of the neurologic symptoms. Seven such cases are reviewed in this report. Although the clinical course is insidious, there are certain features which should signal the presence of a slowly expanding hematoma. After an apparently minor head injury, the patient who is usually in the younger age group, develops headache. This persists and is accompanied by other non-specific neurologic symptoms which may lead to a mistaken diagnosis of "post-concussion syndrome". Papilledema and focal neurologic deficits eventually appear. Definitive diagnosis is made by the CT scan, although contrast enhancement may be necessary to confirm the nature of the lesion. The treatment is craniotomy and evacuation of the hematoma before serious neurologic deterioration occurs.

Adolescent↗
PubMedDate not supplied

Hyperexcitable state of the brainstem in children with post-traumatic vomiting as evidenced by brainstem auditory-evoked potentials.

Brainstem auditory-evoked potentials were studied within 6 hours after mild head injury in 17 children with post-traumatic vomiting. Compared with 8 control subjects, the children with frequent vomiting showed a significant shortening of peak latency for wave III. This mechanism appears to be essentially the reverse of that found in the post-concussion syndrome in which significant delay of wave III has been reported. These findings indicate transient facilitatory effects of trauma on brainstem auditory transmission in post-traumatic vomiting.

Auditory Pathways↗
PubMed1984

Sensitivity to light and sound following minor head injury.

9 consecutively referred closed head injury (CHI) patients were assessed for sensitivity to light and sound stimuli, within 7-19 days of injury, on both objective and subjective measures. Patients were matched with controls on age, sex, race, socio-economic status and order of test administration. The mean luminance (1366 lux) tolerated by CHI patients was significantly lower (0.01 level by Student's t-test for related samples) than that tolerated by controls (1783 lux). The mean sound intensity tolerated by CHI patients was also lower (82 db) than for controls (94 db), though this difference was not statistically significant. Subjective ratings of sensitivity made by CHI patients after exposure to intense sound and light stimuli, showed no relationship to objective ratings of tolerance. The results demonstrate an objective basis for complaints of increased sensitivity, at least to light, following CHI. These findings do not support earlier "psychogenic" explanations of post-concussion syndrome (PCS) etiology.

Adolescent↗
PubMedDate not supplied

Comparison of minor and severe head injury emotional sequelae using the MMPI.

The Minnesota Multiphasic Personality Inventory (MMPI) was administered to 73 patients with traumatic brain injury to objectively evaluate emotional status. Profile analysis indicated that many patients were suffering from emotional disturbance. Higher distress levels were evident among those with minor head injury relative to severe head injury. Observed MMPI profiles for these two head injury groups were consistent with previous research and expectations related to the typical consequences of the post-concussion syndrome. The potential value of the MMPI with the head injury population as well as the need for cautious interpretation and integration of impressions derived from other sources is discussed.

Adult↗
PubMed1988

Head injury. Integrated rehabilitation approach, optimal adaptation to disability.

Comprehensive rehabilitation of head injury means that all somatic, psychological and social consequences of the accident must be taken into account in order to plan the most appropriate individual therapeutic program. A review is given of the epidemiology, the different types of head injuries and the management in the acute stage and the rehabilitation stage with special reference to severe and moderate head injuries as well as minor head injuries and post-concussion syndrome.

Communication Devices for People with Disabilities↗