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Urodynamic assessment of incontinence after prostatectomy.

There were 15 men with incontinence after prostatectomy who were assessed with a urethral pressure profile and a multichannel filling and voiding study with sphincter electromyography. Of these 15 patients 7 had sphincter weakness alone, 7 had sphincter weakness and detrusor hyperreflexia, and 1 had detrusor hyperreflexia alone. Full urodynamic assessment is essential before treatment can be recommended for incontinence after prostatectomy.

Aged

Anterior bladder tube flap reconstruction of the urethrovesical neck after radical retropubic prostatectomy.

Difficulty with urethrovesical neck anastomosis after radical retropubic prostatectomy led us to form an anterior bladder tube flap for anastomosis to the transected urethra in 5 selected cases. We found that combining the anterior bladder tube flap technique with radical retropubic prostatectomy facilitates the urethrovesical neck anastomosis and improves the transient postoperative incontinence sometimes encountered. Results of the 5 patients in whom this technique was used form the basis for a brief discussion of the technique.

Aged

Prevention of bacteriuria after transurethral prostatectomy with nitrofurantoin macrocrystals.

Of 40 patients who underwent transurethral prostatectomy without receiving antimicrobial chemoprophylaxis 13 had significant bacteriuria at some time in the postoperative course. Of 47 patients given nitrofurantoin none of the 42 for whom culture results were available had bacteriuria. This difference between the 2 groups is statistically significant (p less than 0.01). Nitrofurantoin prevents post-prostatectomy bacteriuria and has a theoretical advantage over agents such as the cephalosporins in that its action is limited to the urinary tract.

Bacteriuria

Vesical neck closure versus balloon catheter in suprapubic prostatectomy: a controlled clinical trial.

In a randomized trial comprising 102 cases of suprapubic prostatectomy a modified Hryntschak technique of vesical neck closure was compared to the balloon compression method. There were no statistically significant differences between the 2 groups in operative and postoperative blood loss, duration of operation or postoperative hospital stay. In the vesical neck closure group compared to the balloon catheter group more patients experienced catheters falling out prematurely, as well as more postoperative strictures and more cases of incontinence at followup 1 year later. Our data do not justify the adoption of the vesical neck closure technique in suprapubic prostatectomy.

Aged

The prophylactic use--or misuse--of antibiotics in transurethral prostatectomy.

One hundred non-infected patients undergoing transurethral prostatectomy were randomized prospectively into a controlled study to determine the influence of a prophylactic aminoglycoside (kanamycin) on the clinical course. In the non-risk patient prophylactic kanamycin had no beneficial influence on the incidence of bacteriuria, fever or length of hospitalization. Its use was associated with the development of a resistant Pseudomonas super infection in 1 patient. Prophylactic kanamycin did not protect the patient with carcinoma of the prostate from bacteriuria. There was no identifiable advantage in the use of routine prophylactic kanamycin in the uninfected, non-risk patient who was undergoing elective transurethral prostatectomy.

Aged

A comparison of the morbidity associated with radical retropubic prostatectomy with and without pubectomy.

Radical retropubic prostatectomy with bilateral pelvic lymphadenectomy for prostatic carcinoma was done with pubectomy in 8 patients and without pubectomy in 8 other patients. A comparison of the postoperative courses reveals an excess morbidity in patients who had pubectomy, with severe protracted pelvic girdle pain in 75 per cent, lower extremity thrombophlebitis in 37 per cent (one of which resulted in a non-fatal pulmonary embolus) and varying degrees of urinary incontinence persisting for 6 months or more in 75 per cent. In contrast, in patients who did not have a pubectomy mild transient pelvic girdle pain was noted in only 25 per cent of the cases, late lower extremity thrombophlebitis in 12 per cent and no late urinary incontinence. Pubectomy should not be used routinely with radical retropubic prostatectomy.

Aged

Total prostatectomy for stage B carcinoma of the prostate.

We reviewed 67 cases of total prostatectomy for localized stage B carcinoma of the prostate. There were no operative deaths. Significant morbidity was limited to the well known complications of impotence and incontinence. The over-all survival rates were 92 per cent for 5 years (42 of 46 cases), 79 per cent for 10 years (19 of 24) and 62 per cent for 15 years (8 of 13). Total prostatectomy continues to be the preferred method of therapy for this stage of prostatic cancer.

Adult

Radical retropubic prostatectomy for cancer: a 20-year experience.

A review of 159 patients treated by radical retropubic prostatovesiculectomy from 1951 through 1970 has reinforced our belief that this is a satisfactory method of treatment for prostatic cancer confined to the prostate. A 10-year survival of 55 per cent and a 15-year survival of 45 per cent compare well to the results reported for perineal prostatectomy. The postoperative mortality rate was 2.5 per cent and total incontinence was 12.5 per cent after radical retropubic prostatectomy. Completely normal voiding occurred in 108 of the 159 patients. Stress incontinence but no need for an incontinence device occurred in 31 patients. Improved methods for preoperative staging of the disease give promise for even higher cure rates in the future.

Humans

Factors influencing sexual activity after prostatectomy: a prospective study.

Between 16 and 30 per cent of all prostatectomy patients become impotent after an operation for benign prostatic hyperplasia. Since the surgical technique does not seem to be the factor responsible for such a serious problem, more accentuated by the fact that this operation is becoming increasingly frequent with the increase in life expectancy, an assessment of 15 patients before and after prostatectomy is presented. With a statistical analysis of a structured interview (including a mini-Minnesota Multiphasic Personality Inventory test before and after the operation) 3 main differentiating factors emerged between the potent and the impotent group: 1) the level of anxiety exhibited by the patient, 2) whether the patients received an explanation about the surgery and its outcome prior to the operation and 3) the patient's general satisfaction with life.

Aged

The use of furosemide in the postoperative management of prostatectomy: a prospective investigation.

We estimated the effect of forced diuresis in the postoperative management of prostatectomy in a prospective, controlled clinical investigation. The need for bladder irrigation in a group of patients treated with furosemide is compared to that in a group not treated with this drug. The chi-square test showed no significant difference between the 2 groups. Therefore, there is no indication for furosemide in the postoperative management of patients subjected to prostatectomy.

Adult

George Washington University technique for surgical correction of post-prostatectomy incontinence.

We have described a procedure with long-term followup and modification for the correction of post-prostatectomy incontinence. The procedure involves the combined principle of rigidly placed support under the urethra to which is attached an inflatable, adjustable pillow, allowing for fine control of the urethral resistance. Of the 22 patients treated 16 are completely dry, 4 have occasional dampness and 2 are failures. More significant is the fact that since the silicone gel pillow has been enclosed in the marlex strap we have had 6 successes., 1 partial successs and no failures. The complication rate is almost non-existent. No infections were encountered and no prostheses were removed for other than reoperation. We believe that the combination of bony fixation plus the adjustable pillow gives the best control of the troublsome problem of post-prostatectomy incontinence.

Aged

Simultaneous open prostatectomy and inguinal herniorrhaphy.

We report our results in 18 patients who had simultaneous open prostatectomy and inguinal herniorrhaphy between 1969 and 1976, and present our criteria for patient selection, operative technic, and postoperative results. The incidence of postoperative wound infection and recurrent hernia was 5.6% and 0 respectively, which compares favorably to results of herniorrhaphy and prostatectomy performed separately. The historic development of this procedure and the results of previously reported series are reviewed.

Hernia, Inguinal

Prostatectomy with a no-catheter technique.

A method of no-catheter prostatectomy is described and the results of 350 operations are presented. It has been demonstrated that this method of prostatectomy can be done aseptically.

Humans

Complications of antifibrinolysis therapy after prostatectomy.

As part of a trial to compare the effectiveness of various agents which have been claimed to reduce blood loss after prostatectomy, tranexamic acid (AMCA) was given pre-operatively and post-operatively to 6 patients having routine transurethral resections. Three of these developed indissoluble intravesical blood clots which persisted until they were evacuated surgically 5 to 17 days after cessation of AMCA therapy. AMCA cannot be recommended for routine use after prostatectomy.

Cyclohexanecarboxylic Acids

The influence of prostatic anatomy on the differing results of prostatectomy according to the surgical approach.

An anatomical study of cadaver prostates has demonstrated that, in all cases, adenomatous tissue lies inferior to the verumontanum. The proportion of tissue distal to the verumontanum varies from less than 10 to 50%. In a series of 100 patients the post-operative urodynamic studies showed that in the tansurethral resection group the mean urethral length was longer, the flow rate lower and the residual urine higher than in the retropubic prostatectomy group. It is suggested that prostatectomy by the transurethral route is less complete due to residual sub-verumontanal prostatic tissue. However, it is likely that by restricting resection to supra-verumontanal tissue many patients are spared post-operative stress incontinence.

Aged

The effect of prostatectomy on urodynamic parameters.

Sixty per cent of men subjected to prostatectomy had unstable bladders. It was found that this was related to the presence of either an indwelling catheter or obstruction, but had little influence on the result of prostatectomy. The functional urethral pressure profile length did not correlate with the size of the prostate gland. Shortening of the prostatic plateau was always found, but the extent to which the plateau was reduced did not correlate with urine flow rates.

Adult

Androgens in patients with benign prostatic hyperplasia before and after prostatectomy.

Plasma androgens [testosterone (T), 17beta-hydroxy-5alpha-androstan-3-one (DHT), androst-4-en-3,17 dione(A), and dehydroepiandrosterone (DHEA)] as well as 17 hydroxyprogesterone were measured in a group of patients (age 60-80 yrs.) with benign prostatic hyperplasia (BPH) just before prostatectomy and compared to values obtained in subjects of similar age without signs of BPH. The most important difference was observed in the mean DHT level which was significantly (P less than 0.025) higher than in the control group; mean T and free testosterone levels in BPH patients were slightly higher (P less than 0.05) in the age group 70-80 yrs; whereas in age group 60-70 mean values were similar to those observed in normal controls. Mean A, DHEA and 17 OHP and E2 levels were not significantly different in BPH patients when compared to age matched controls. 2-5 months after prostatectomy, T and DHT levels were significantly higher than immediately preoperatively. The preoperative stress may have influenced the preprostatectomy values.

Aged

A simple hemostatic method in suprapubic prostatectomy: extracapsular pulling sutures.

To block the vessels of the prostate, extracapsular pulling sutures were placed from the 4 and 8 o'clock positions on the bladder neck to the perineum prior to enucleation in 25 cases of prostatectomy. The removable pulling sutures successfully reduced blood loss during and after prostatectomy. Besides, the average operating time was markedly shortened. Postoperative courses of the patients were uneventful on the whole and there was no remarkable complication.

Hemostasis, Surgical