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PubMed1977

A seriological investigation of Q fever in clinical patients.

Results of a serological survey of 507 patients, 301 males and 206 females at the Ahmadu Bello University Teaching Hospital indicated a total 20.5 per cent, or 21.3 per cent in males and 19.4 per cent females, had been exposed to Q fever agent and had circulating antibody against Coxiella burnetii. Most of the positive sera were from patients whose clinical diagnoses were typhoid and pyrexia of unknown origin though these generally are the commonest clinical diagnoses in the hospital. Titres varied from 1:4 to 1:1028 indicating old infections in some patients and acute in others. The results of normal blood donors also showed a 22 per cent positive. It is suggested that the presumptive evidence of the serological tests results be substantiated by isolation of the agent so that a correlation between clinical signs and evidence of Q fever infection be established.

Agglutination Tests↗

PubMed1978

Prevalence of Coxiella burnetii (Q fever) and Toxoplasma gondii among dairy goats in California.

The prevalence of antibodies against Coxiella burnetii and Toxoplasma gondii, the causative agents of Q fever and toxoplasmosis, was examined in goats to determine the extent of the potential of goats to tansfer these infections to persons. Of 1,054 goats from 234 premises in California, 248 goats (24%) were seropositive for C burnetii and 246 (23%) were seropositive for T gondii. Of 29 dairy goats tested, 2 (7%) were found to be shedding the Q fever rickettsia in their milk; T gondii was not detected. Factors of sex, age, location, and herd size are discussed.

Age Factors↗

PubMed1979

Cynomolgus monkey model for experimental Q fever infection.

A subhuman primate model was developed for study of the pathogenesis of infection with Coxiella burnetii. Cynomolgus monkeys (Macaca fascicularis) that were exposed to 10(5) mouse median infectious intraperitoneal doses of C. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of Q fever infection in humans. All monkeys had radiologic evidence of pneumonia by day 9. Antibodies to C. burnetii were detectable by the indirect fluorescent antibody test by day 7. These data indicate that the cynomolgus monkey is a suitable model for study of the pathogenesis of Q fever infection and may prove valuable in the evaluation of C. burnetii vaccines.

Aerosols↗

PubMed1978

[Mononucleosis syndrome and thrombocytopenic purpura in Q fever (Rickettsia burneti)].

Case of a patient with a mononucleosis syndrome and thrombocytopenic purpura during Q Fever. This etiology could lead to a systematic search for a rickettsial cause for such a symptomatology with a negative Paul-Bunnell-Davidson reaction.

Adolescent↗

PubMed1979

[Q fever in the Mordvinian ASSR].

In the serological (CFT) examination of patients with elevated temperature for Q fever positive results were obtained in 8.2--14% of cases. The number of positive results of the CFT in rural districts was higher (16%) than in urban districts (10.2%). A considerable percentage of positive results was observed among the workers of a meat-packing plant (25%) and among persons who regularly received milk at their work as a special diet (25--39.2%). In the Mordovian ASSR the infection seemed to be transmitted mainly by the alimentary and contact ways.

Adolescent↗

PubMed1979

[Endocarditis by Coxiella burnetti. A chronic form of Q fever. Report of one case (author's transl)].

The authors describe a case of chronic endocarditis by Q fever, in a patient who had been operated for coarctation of the aorta twelve years previously and at the same time was carrier of a congenital bivalve aorta. The clinical picture was suggestive of subacute endocarditis, but the blood culture was negative repeatedly. There was also a prolonged and relapsing febrile syndrome over a period of one-year-and-a-half. The following data are also worthy of note: the coexistence of a liver disorder and a focal and segmentary glomerulonephritis. Based on some recent publications (one by the same group) the authors feel that Coxiellosis burnetti must be more frequent in their environment than is suspected.

Adult↗

PubMed1977

[Pathologo-anatomic and experimental study of the morphology of Q-fever].

The article presents a survey of the literature containing reports on lesions of some human organs in Q-fever and on a possible role of the pathogene--Rickettsia burnetii in the development of these lesions. Pathoanatomical findings were compared with those of the experimental investigations of the Q-rickettsial infectious process. The literature data and the author's own investigations confirm the capability of Rickettsia burnetii of parasitizing in cells of the reticulo-endothelial system. This is an important factor in the pathogenicity of this causative agent and lies at the root of the pathogenesis of Q-rickettsial infection.

Animals↗

PubMed1978

[Cattle vaccination against Q fever in the rural district of Bratislava].

Cattle attendants on two farms in the Outer Bratislava district showed symptoms of Q-fever. The blood of the cows in these farms was found to contain antibodies to Coxiella burnetti and the causative agent of the disease was detected in milk samples of aborting cows by biological assays on hamsters (Mesocricetus auratus). The naturally invaded dairy cows with antibodies in the blood and heifers without antibodies were vaccinated with different doses of inactivated suspension of C. burnetii in stage I. A different antibody reaction to vaccination was obtained after the application of a four-fold amount of vaccine. It was proved that the animals did not excrete the causative agent of the infection even after administration of lower doses of the vaccine on the 120th day after vaccination.

Animals↗

PubMed1979

Poikilotherms as reservoirs of Q-fever (Coxiella burnetii) in Uttar Pradesh.

Water snakes (Natrix natrix), rat snakes (Ptyas korros), cobras (Naja naja), pythons (Python molurus), tortoises (Kachuga sp.), plankton fish (Cirrhina mrigala), frogs (Rana tigrina), toads (Bufo sp.) and monitors (Varanus indicus) were screened for evidence of Q-fever infection by the capillary agglutination test on sera to detect antibodies and/or by attempts to demonstrate Coxiella burnetii in spleen and liver samples. Sero-reactors were observed among water and rat snakes, pythons and tortoises. The organism was isolated from the spleen and liver of the monitor, tortoise and python.

Amphibians↗

PubMed1978

Serum Q fever antibodies in Swedish UN soldiers in Cyprus--reflecting a domestic or foreign disease?

Swedish soldiers from 2 battalions serving in Cyprus 1975 and 1976 were tested serologically for Coxiella burnetii phase 2 complement-fixing antibodies. 2.7% were positive. Although none of the seropositive soldiers had been seriously ill abroad, the titers are considered to emanate from an infection in Cyprus as there is no evidence of domestic Q fever from a survey of 1390 Swedes.

Antibodies, Bacterial↗

PubMed1979

Chronic cryptic Q-fever infection of the heart.

Evidence of chronic Coxiella burneti infection of the heart, a disease previously considered peculiar to patients with valvular heart-disease, was found in a patient during routine serological tests before resection of a ventricular aneurysm and also by isolation of the rickettsia from the resected tissue. The patient had no symptoms or signs of Q-fever endocarditis and none of the laboratory evidence usually associated with it.

Antibodies, Bacterial↗

PubMed1976

Q fever in cattle and sheep in Southern Africa. A preliminary report.

In the course of a study initiated to elucidate the role of known abortifacient in ruminants in Southern Africa, Coxiella burnetti was identified in smears prepared from bovine and ovine placental tissues obtained from 12 farms. The organism was also isolated in embryonated eggs, and specific antibodies were demonstrated in sera of animals originating from these farms. In 7 of the 12 herds in which Q fever was diagnosed, other pathogens were identified concomitantly.

Animals↗

PubMedDate not supplied

Observation on chemotherapy in cows chronically infected with Coxiella burnetii (Q fever).

Pregnant dairy cows chronically infected with Coxiella burnetii were treated orally with 8 mg of chlortetracycline per kilo of body weight each day for 30 days during their dry period. With the exception of a sample of mammary fluid collected at 28 days, rickettsiae were not recovered from the mammary fluids after the second week of treatment. In addition, the organism was not recovered by mouse inoculation from placental tissues, colostrum or calf tissues that were examined after parturition. Results of oral chemotherapy studies in cows and guinea-pigs suggest that in some cases chlortetracycline may suppress rather than eradicate the Q fever agent.

Animals↗

PubMed1992

[Occurrence of infections with C burnetii (Q fever) in persons from increased risk groups in Poland--serological survey and evaluation of studied methods].

During years 1988-1991 at Regional Sanitary and Epidemiological Stations in Białystok, Kielce, Lublin, Leszno, Piotrków Trybunalski, Lódź, Poznań, Plock, Opole, Sanok, Skierniewice and Zielona Góra--serological studies in persons amenable to compulsory check-up against brucellosis were performed for detection of infections with C. burnetii. In whole, 20651 persons were investigated on the Polish territory and it was found that in 22.8% antibodies against antigens of C. burnetii are present. Percentage of persons with detected antibodies varied in different regions from 0 to 41.7%. No antibodies were found in persons inhabiting regions of Kielce, Piotrków Trybunalski and Skierniewice. Most persons with antibodies indicating contact with C. burnetii were found in West Poland, namely in the Leszno and Poznań region. As in diagnosis of Q fever two methods (OWD and OMA) or OWD only were applied, it is difficult to compare results obtained in regions using two or only one method of determination.

Antibodies, Bacterial↗

PubMed1975