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PubMed1960

Biological properties of ribonucleic acid from virulent and attenuated poliovirus.

Concentrates of type I poliovirus were extracted with phenol by Gierer and Schramm's method. The infectivity of these extracts in tissue culture and mice appeared to be associated with viral RNA. Studies on neurovirulence based on the "t" marker and intraspinal pathogenicity in mice demonstrated that the viral progeny of RNA isolated from virulent viruses had the "t(+)" character and were highly neurotropic for mice. Conversely, RNA extracted from attenuated virus gave rise to a progeny of "t" type which were avirulent for mice. The results suggest that the infective RNA from type, I poliovirus carries the genetic information which determines the degree of neurovirulence.

Animals↗
PubMed1962

Biosynthesis of infectious tobacco mosaic virus ribonucleic acid in a cell-free medium.

When cell-free preparations containing large molecules and subcellular bodies extracted from tobacco-leaf cells infected with tobacco mosaic virus were incubated with MgCl(2) and the four ribonucleoside-5'-triphosphates, the level of infectivity increased about threefold in 30 minutes. The mechanism synthesizing the new infectivity was believed to be located within isolated nuclei. Ultrasonic rupture of the nuclear membranes appeared to increase the rate of synthesis.

Cell Nucleus↗