PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Recovery of Function”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed1978

A new method of measuring functional recovery after crushing the peripheral nerves in unanesthetized and unrestrained rats.

The distances between the first and fifth digits and between the second and fourth digits of the rat's hind paw were measured after crushing the sciatic nerve. The distances between the digits recovered significantly faster in weak nerve crushing than in strong crushing, and faster in distal nerve crushing than in proximal crushing. These results suggest that this method is available for evaluating the functional recovery after nerve crushing.

Animals↗
PubMed1975

Functional recovery from spinal cord trauma following normothermic irrigation in dogs.

The spinal cords of 16 normal dogs were exposed via dorsal laminectomies and damaged with a known impact force. In eight dogs the injured portions of the spinal cords were irrigated, without durotomy, for 2 h with normothermic saline. The remaining eight dogs were used as controls and were not irrigated. The results showed that normothemic irrigation of damaged spinal cords, immediately after impact trauma, had a significant beneficial effect on the functional recovery of the spinal cords.

Animals↗
PubMed1992

[Evaluation of renal function and prediction of renal functional recovery in children with unilateral hydronephrosis using renal pelvic urine].

In 29 children with unilateral hydronephrosis who underwent surgery at the age from 2 months to 15 years (27 patients with ureteropelvic junction stenosis and 2 with obstructive megaureter), beta 2-microglobulin (beta 2-MG), alpha 1-microglobulin (alpha 1-MG), N-acetyl-beta-D-glucosaminidase (NAG) and albumin were determined in renal pelvic urine from the hydronephrotic kidney to evaluate renal dysfunction accompanying urinary tract obstruction. Moreover, it was also examined whether it is possible to predict functional recovery of the hydronephrotic kidney on the basis of relation between these indices and pre- and postoperative changes in renal dimercaptosuccinic acid (DMSA) uptake rate. The values of beta 2-MG, alpha 1-MG, NAG and albumin in urine from the renal pelvis were high in 48%, 50%, 75% and 83% of the patients, respectively. Among the patients of one year and up, those with low preoperative DMSA uptake rate tended to have high values of beta 2-MG, alpha 1-MG and NAG. On the contrary, albumin level was high in 78% of patients who had good preoperative DMSA uptake rate. With respect to the relation between pre- and postoperative changes in DMSA uptake rate and each index, beta 2-MG and alpha 1-MG were high in 73% and 62% of patients who exhibited a marked increase in postoperative DMSA uptake rate. In patients without a remarkable change in DMSA uptake rate before and after surgery, on the other hand, the values of these were high only in 25% and 36%.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetylglucosaminidase↗
PubMed1979

Lack of functional recovery from spinal cord trauma following dimethylsulphoxide and epsilon amino caproic acid therapy in dogs.

The spinal cords of 20 normal dogs were exposed via dorsal laminectomies at L1 and damaged with a direct impact force of 440 g cm. One hour later treatment with dimethylsulphoxide (DMSO) was started on 10 dogs and with epsilon amino caproic acid (EACA) on the other 10 dogs. Administration of the DMSO ceased at 41 h after trauma and EACA at 49 h. The results showed that neither drug had a significant beneficial effect on the functional recovery of the spinal cords, when compared to a control group of similarly traumatised dogs.

Aminocaproates↗
PubMed2026

Effects of different resistance exercise programs on upper limb functional recovery in postoperative breast cancer patients.

PURPOSE: To investigate the effects of grip strength exercise combined with upper limb resistance exercise on upper limb functional rehabilitation in patients after breast cancer surgery. METHODS: A total of 111 patients who underwent either modified radical mastectomy with ALND or breast-conserving surgery with ALND were randomly assigned to a control group, an upper limb resistance exercise group, and a combined grip and upper limb resistance exercise group. Grip strength was measured at baseline, 16 weeks after intervention, and at 3- and 6-month follow-ups, while shoulder function was assessed using the Constant-Murley Scale (CMS). RESULTS: There were no statistically significant differences in grip strength or CMS scores among the groups before intervention (P&#x202f;>&#x202f;0.05). At the post-intervention, 3-month, and 6-month follow-ups, compared with the control group, both resistance training protocols significantly improved patients' joint range of motion, pain, muscle strength, total CMS score, and grip strength (P&#x202f;<&#x202f;0.05). Compared with the upper limb resistance exercise group, the combined grip and upper limb resistance exercise group demonstrated superior grip strength at the 6-month follow-up (P&#x202f;<&#x202f;0.05), as well as more significant improvements in joint range of motion, pain, muscle strength, and total CMS scores (P&#x202f;<&#x202f;0.05). CONCLUSION: A 16-week resistance exercise program effectively improves upper limb function in post-surgical breast cancer patients, with the combined grip and upper limb resistance exercise program yielding superior outcomes.

Humans↗
PubMed1992

Freezing preservation of the mammalian cardiac explant. VI. Effect of thawing rate on functional recovery.

This study investigated the effect of thawing rate on the preservation of frozen isolated rat hearts. The hearts were flushed with a hyperosmotic cardioplegic solution, CP-14/EtOH (1.15 Osm/kg), frozen at a rate of 0.18 degree C/hr for 6 h to -3.2 degrees C. Thereafter, the hearts were thawed at rates ranging from 0.08 to 1.1 degrees C/min for 1 to 14 min until the heart temperature reached -2.1 degrees C, the melting point (MP) of the flush solution; then they were held at -1 degree C for 11 to 24 min so that the total thaw time was 25 min. Post-thaw function was assessed by working reperfusion and expressed as percentage of unstored control function. Cardiac output (CO) and other hemodynamic performance showed biphasic responses to the thaw rate. At 0.08 degree C/min rate, CO recovered to 29.1 +/- 4.1 ml/min (40.8 +/- 5.8% of control). Thawing at 0.13 degree C/min enhanced the recovery of CO to 60.5 +/- 4.9%. Between 0.13 and 0.34 degree C/min, recovery was statistically insignificant. Faster thawing at 0.59 and 1.1 degrees C/min caused progressively less recovery. Overall, 0.13 degree C/min offered the highest recovery. In conclusion, function in slowly frozen heart is intimately affected by the thawing rate; there was an optimal intermediate thawing rate and both too slow and too fast thawing were detrimental.

Animals↗
PubMed1976

Functional recovery with and without training following brain damage in experimental animals: a review.

Review of observations on experimental animals following brain damage shows that some functions may recover spontaneously and functional accomplishment can be increased by training even with unchanged reflex status. Training consists of a combination of two basic techniques: forced use of the impaired body part, and instrumental conditional relfexes. The possible mechanisms of recovery include restoration by an alternative pathway, compensation through complicated interactions among brain structures and, with training, activation of a parallel system essential to conditioned responses. Factors, such as motivation and emotion, may complicate the course of recovery. Results of recovery with training in experimental animals strongly indicate that such training can play an active and specific role in functional improvement following brain damage in man. Future development of rehabilitation medicine in this direction is suggested.

Animals↗
PubMed1979

Motoneuronal excitability during wakefulness and non-REM sleep: H-reflex recovery function in man.

Comparisons were made in 13 normal young adults of alpha motoneuronal excitability during non-rapid-eye-movement (NREM) sleep (stages 2--4) and wakefulness based on a study of the recovery cycle of the H-reflex after a conditioning stimulus. During sleep, excitability was generally decreased and a peak of secondary facilitation, which characteristically occurs 100--300 msec after the conditioning stimulus during wakefulness, was reduced or absent. A variety of mechanisms, including long-loop reflexes and afferent discharges from reflex muscle contraction and cutaneous fibers, has been proposed to account for this phase of facilitation in the waking recovery curve. However, since studies to date indicate the absence of tonic presynaptic or postsynpatic inhibitory influences acting on the monosynatpic reflex pathway during NREM sleep, but report tonic reduction in fusimotor activity at this time, it is suggested that a primary factor underlying the absence of facilitation during sleep is a reduction in central excitability deriving from depressed fusimotor activity.

Adolescent↗
PubMed1992

Long-term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration.

Hepatocyte cryopreservation is essential to ensure a ready supply of cells for use in transplantation or as part of an extracorporeal liver assist device to provide on-demand liver support. To date, most of the work on hepatocyte cryopreservation has been performed on isolated hepatocytes, and has generally yielded cells which display low viability and greatly reduced short-term function. This report presents the development of a freezing procedure for hepatocytes cultured in a sandwich configuration. A specially designed freezing unit was used to provide controlled temperatures throughout the freeze-thaw cycle. Cooling rate, warming rate, and final freezing temperature were evaluated as to their effect on hepatocyte function as judged by albumin secretion. Under optimized conditions (cooling at 5 degrees C/min and warm at > or = 400 degrees C/min), freezing to -40 degrees C resulted in full recovery of albumin secretion within 2-3 days post-freezing, whereafter albumin secretion levels remained normal for the duration of the experiments (2 wks). Freezing to -80 degrees C lead to an approximate 70% recovery of long-term protein secretion when compared to control cultures. In addition, the overall hepatocyte morphology as judged by light microscopy, closely followed the functional results. The sandwich culture configuration, thus, enables hepatocytes to maintain a satisfactory level of long-term protein secretion after a freeze-thaw cycle under optimized conditions, and offers an attractive tool for further studies into the mechanisms of freezing injury and subsequent hepatocellular recovery. These results are a promising step in the development of satisfactory storage procedures for hepatocytes.

Animals↗
PubMedDate not supplied

[Functional recovery in subtotal laryngectomies].

Subtotal laryngectomy, a valid treatment for carefully selected patients, is a safe oncologic procedure which preserves the cricoid-arytenoid unit creating a successful "neo-larynx" with valid phonatory and deglutition functions. At the E.N.T. Clinic of "La Sapienza" University of Rome from Jan. 1984 to Feb. 1992, 85 subjects underwent subtotal laryngectomy, 50 of which then underwent phoniatric examination. The remaining patients were not suitable candidates because of the trachealis cannula (14), or because they were lost at follow up (16). A total of 50 male subjects were examined. Twenty-eight underwent crico-hyoid-pexia, while 22 patients underwent crico-hyoid-epiglotto-pexia. Attention is drawn to the results which appear to be extremely variable with regard to each study group. We obtained better results with crico-hyoid-epiglotto-pexia than with crico-hyoid-pexia and we guaranteed a good social re-insertion in all cases.

Aged↗
PubMed1976

Head injury in children and teenagers; functional recovery correlated with the duration of coma.

Residual impairments and mortality were assessed in 48 patients under 20 years of age at least two years after a traumatic head injury had caused coma lasting more than seven days. In this study the duration of coma was defined as the period of time when it is impossible to establish intellectual contact with the patient. A classification of functional levels 1 to 8 was used to identify the residual impairment and relate this impairment to the duration of coma for each patient. Of 30 patients who remained in coma less than three month, only one did not have independent ambulation with or without equipment at the time of his last follow-up evaluation. This was one parameter among others to show that the prognosis for recovery in this age group is much better than expected following severe head injury. These follow-up data, correlated with the duration of coma, can assist rehabilitation personnel in the prognostic planning for younger people with severe head injuries. Rehabilitation medicine needs to be involved in patient care during the period of coma to prevent contractures and other complications which often interfere with and delay later rehabilitation programs, making them more costly and less successful.

Adolescent↗
PubMed1975

Functional recovery from spinal cord trauma following delayed incision of spinal meninges in dogs.

The spinal cords of 16 normal dogs were exposed via dorsal laminectomies and damaged with a known force. In eight dogs the spinal cord meninges were incised longitudinally after a delay of 2 h. The other eight dogs were kept as controls and their meninges were not incised. The spinal cord function of all dogs was monitored for up to 32 days. The results show that delayed incision of the spinal meninges is of little benefit to dogs following experimental trauma to the spinal cord.

Animals↗
PubMed1975

Topography and topology in functional recovery of regenreated sensory and motor systems.

Motor and sensory nerves can re-establish coordinated movement and accurate sensation when they regrow into denervated tissues of some lower vertebrates. Motor nerves achieve their end by a competitive process in which each motoneuron innervates many muscle fibres but, in the presence of many applicants, only those synapses from motoneurons most appropriate to a muscle cell, with respect to the original pattern of development, are retained in a functional state. The discharge pattern of a motoneuron, determined by its connections with the network of central interneurons, is not sensitive to the location of the muscles in which the axon terminates, but the efficacy of transmission from the terminals is. Sensory nerves re-establish their functional specificity as to receptor type by an inductive process occurring at the terminals along with the cessation of growth. However, in the case of cutaneous nerves they can terminate anywhere over the skin surface. The return of correctly localized reflex behaviour therefore demands a restructuring of the central nervous system in response to local position-specific signals, presumably of developmental origin, that are supplied to the sensory nerves by the skin. The re-arrangement of the central nervous connections made by the central processes of the sensory neurons probably uses the same competitive mechanism of enabling and disabling formed synaptic connections as is used in sorting out the correct site of functional termination of the peripheral processes of motoneurons.

Animals↗
PubMed1978

Block design performance following callosal sectioning. Observations on functional recovery.

A patient with complete surgical section of the corpus callosum was tested on a constructional task 17 months post-operatively. The left and right hands were separately tested under conditions of free visual exposure and lateralized visual field exposure. The results suggest that the typically observed improved performance of the right hand with increasing postoperative time is attributable to the acquisition of homolateral control over the right hand by the right hemisphere. The implications for left-right brain organization and the syndrome of constructional apraxia are considered.

Adolescent↗
PubMed1992

Effects of BIM-22015, an analog of ACTH4-10, on functional recovery after frontal cortex injury.

Male rats, 90-100 days old, with frontal cortex lesions were given either subcutaneous sterile water (SW) as a vehicle control or 1, 10, or 100 micrograms of BIM-22015 every other day for 20 days. Brain-injured subjects tested in the Morris water maze with either 10 micrograms BIM-22015 or SW took significantly more trials than sham-operated rats to locate a submerged platform eight consecutive times within 60 s. The animals given 1 or 100 micrograms BIM-22015 took significantly fewer trials to reach criterion than brain-injured animals in the other drug treatment groups. On a percentage of savings, measured 8 days after reaching criterion, the brain-injured subjects given 1, 10, or 100 micrograms BIM-22015 did not differ from sham-operated rats. In contrast, the brain-injured animals given SW took longer to find the submerged platform than they did during the initial training. To assess long-term effects of the ACTH analog treatment, rats were trained on a delayed spatial alternation task 30 days after receiving the last injection. On this task, brain-injured rats treated with the 10-micrograms dose performed significantly better than those given sterile water. Acetylcholinesterase (AChE)-labeled neurons counted in the nucleus basalis magnocellularis indicated that rats with frontal cortex damage given the 10-micrograms treatment did not differ from the sham controls and had significantly more AChE-positive neurons than injured counterparts treated with SW or 100 micrograms.

Acetylcholinesterase↗
PubMed1976

Comparison of histologic and functional recovery after peripheral nerve repair.

After repair, nerve stains of skin and subcutaneous tissue biopsies of 23 fingertips contained identifiable axons in all patients. The level of recovery was more advanced in some patients than in others, as manifested by identifiable nerve in various plexuses and receptors. Meissner's corpuscles were observed to be reinnervated in 12 of 17 patients and in 16 of 23 fingertips. The degree and level of reinnervation did not correlate with clinical testing or subjective impression of the result. The authors conclude that sensibility is the result of several factors active in the peripheral and central nervous system. Axonal regrowth is but one of these.

Adolescent↗