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At least 37 records · Page 2Linked to original sources
PubMed1975

Effect of prophylactic and therapeutic administration of BCG vaccine on growth of experimental sarcoma.

The effect of prophylactic and therapeutic administration of BCG vaccine on growth of transplantable sarcomas induced by MSV-Harvey (MSVT1) and 3-methylcholanthrene (MC 11 and MC 12) in C57BL/10Sn mice was studied. Growth of MSVT1 sarcomas was not inhibited by oral or intratumoral BCG therapy. Nor was prophylactic oral administration of BCG followed by therapeutic oral BCG treatment effective. On the other hand, intradermal administration of an adequate dose of BCG vaccine preceding the tumour transplantation inhibited tumour growth. The low (0.05-0.2 mg.) doses of BCG induced resistance comparable to the effect of subcutaneous immunization with tumour cells, whereas the higher (0.5-1.0 mg) doses had no effect. Growth of MC 11 and MC 12 tumours was not affected by prophylactic intradermal BCG administration.

Administration, Oral↗
PubMedDate not supplied

[Combined effect of hyperglycemia and chemo- and radiation action on the status of metabolic processes in certain experimental sarcomas in rats].

A number of metabolic parametres were studied in subcellular fractions of rat sarcoma 45, M-1 and carcinosarcoma Worker 256. Administration of high doses of glucose amplified some effects of chemotherapeutic drugs and X-ray therapy, which were manifested as follows: a decrease in glycolysis rate, alteration in the rate of redox reactions, shifts in the ratio between glycolysis and biological oxidation in mitochondria. These alterations were determined by the type of sarcoma, by sequence of operations in the procedure and by cytostatic used. The most effective procedure proved to be simultaneous administration of drugs and X-ray therapy followed by hyperglycemia. Distinct inhibition of glycolysis defected under these conditions may contribute to inhibition of energy metabolism during the sarcoma growth and regression.

Amino Acids↗
PubMed1998

Morphometric and kinetic analysis of the growth of experimental sarcoma-45 in the presence of Ukrain.

The effect of the antitumor agent Ukrain on the growth kinetics of the experimental tumor sarcoma-45 was studied by correlation analysis. Sarcoma-45 was implanted into 28 Wistar rats in the subcutaneous layer of a lateral site of the trunk. Fourteen animals received i.v. Ukrain every other day in a dose of 30 mg/kg (0.1 LD50). The other 14 rats served as controls. Macromorphometry of the tumor nodes of sarcoma-45 was carried out every day in both groups. Statistical analysis of morphometric data and plotting of histograms were performed. Regression equations were selected and their parameters determined. A mathematical model was assessed. The effectiveness of Ukrain treatment was analyzed using the equivalent exponent method. Ukrain was proved to be an effective antitumor agent on biological and mathematical models in accordance with standardized instructions for screening.

Alkaloids↗
PubMed1997

Hypoxyradiotherapy: lack of experimental evidence for a preferential radioprotective effect on normal versus tumor tissue as shown by direct oxygenation measurements in experimental sarcomas.

AIM: In order to investigate possible pathophysiological mechanisms underlying the postulated preferential protective effect of hypoxia on normal tissue during radiotherapy, the impact of acute respiratory hypoxia (8.2% O2 + 91.8% N2) on tissue oxygenation was assessed. METHODS: Tumor and normal tissue oxygenation was directly determined using O2-sensitive electrodes in two experimental rat tumors (DS and Yoshida sarcomas) and in the normal subcutis of the hind foot dorsum. RESULTS: During respiratory hypoxia, arterial blood O2 tension (pO2), oxyhemoglobin saturation and mean arterial blood pressure decreased. Changes in the arterial blood gas status were accompanied by a reflex hyperventilation leading to hypocapnia and respiratory alkalosis. In the subcutis, tissue oxygenation worsened during acute hypoxia, with decreases in the mean and median pO2. Significant increases in the hypoxic fractions were, however, not seen. In tumor tissues, oxygenation also worsened upon hypoxic hypoxia with significant decreases in the mean and median pO2 and increases in the size of the hypoxic fractions for both sarcomas. CONCLUSION: These results suggest that during respiratory hypoxia, radiobiologically relevant reductions in the oxygenation (and a subsequent selective radioprotection) of normal tissue may not be achieved. In addition, in the tumor models studied, a worsening of tumor oxygenation was seen which could result in an increased radioresistance.

Animals↗
PubMed1980

Influence of glucocorticoids on the cellular immune response evoked by an experimental sarcoma in rats.

A test system to evaluate the influence of antineoplastic drugs on the cell-mediated immune response evoked by an experimental rat carcinoma is presented. Thoracic Duct cells from W 49 tumor-bearing WF rats were added to monolayers of 51Cr-labelled tumor cells. A clear cytotoxic effect was noted. In vivo glucocorticoid treatment of rats after tumor inoculation prevented the appearance of such cells. In vivo tumor growth rate was not affected.

Animals↗
PubMed2002

Effect of blood transfusion in an experimental sarcoma model.

OBJECTIVE: To study the effect of allogeneic, syngeneic, and autologous blood transfusion on the growth rate of the KHT tumor in a C3H murine model. DESIGN: Prospective, randomized, and controlled animal study. SUBJECTS: Sixty-one C3H female mice. INTERVENTIONS: The C3H female mice were implanted with 2 x 10(5) cells of KHT, a murine sarcoma. Ten days later, 0.3 mL of blood was removed from a retro-orbital site to simulate surgical blood loss. This blood loss was replaced by blood transfusion through a tail vein with the use of allogeneic (major histocompatibility complex incompatible), syngeneic (major histocompatibility complex compatible), or autologous blood. Tumor growth was measured daily for 14 days. The tumor growth curve for each of the animals was constructed and the mean slope of growth calculated for each group. RESULTS: There were statistically significant differences in tumor growth rate (P =.001) when the allogeneic group (mean slope = 0.232, n = 14), the syngeneic group (mean slope = 0.190, n = 17), and the autologous group (mean slope = 0.202, n = 14) were compared. A t test confirmed that there was no significant difference in the tumor growth rate between the groups transfused with syngeneic and autologous blood (P =.26). However, the rate of tumor growth in the allogeneic group was found to be significantly higher when independently compared with the syngeneic group (P<.001) and the autologous group (P =.02). CONCLUSIONS: In this experimental model of a solid murine sarcoma, allogeneic blood transfusion was associated with an increased rate of tumor growth compared with syngeneic and autologous blood transfusion, likely reflecting immunomodulatory effects incurred by the introduction of major histocompatibility complex-incompatible antigens.

Animals↗