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[Endoscopic and intraoperative ultrasonography in staging of stomach neoplasms].

In Japan a better prognosis of gastric cancer has been achieved by early diagnosis and wide, careful lymphectomy. This is not true in western countries. Thus the Authors believe that rational surgical strategy and the careful use of advanced diagnostic tools would produce a better outcome. The Authors report the new diagnostic methods that they adopt in every case of gastric neoplasm: endoscopic ultrasonography, which also proved useful in submucosal tumors, like lymphomas; parenteral nutrition, immune status assessment for a possible use of immune response modulators, single-dose antimicrobial prophylaxis, antithrombotic prophylaxis, autologous blood storage, in order to reduce transfusion-linked risks. Surgical strategy is also reported, which includes wide resection with adequate margins, R2 lymphectomy and intraoperative assessment of disease extension by ultrasonography.

Gastroscopy↗

[Advanced stomach neoplasms: expression of the fixation index of bromodeoxyuridine in vivo].

We studied fixation of bromodeoxyuridine by immunohistochemistry in 17 patients with advanced gastric cancer. Macroscopically, they corresponded to Borman's types III (n = 10), IV (5) I (1) and unclassified (1). 11 patients had a diffuse lesion, 5 an intestinal type lesion and 1 an epidermoid carcinoma. Positive reactions were observed in 27.7% of cells (95% CL 10-48%). No difference was observed in positivity of superficial (29%) or deep areas of the tumor (27%). Greater fixation rates were observed in patients under 50 years, of age compared to older patients. The percentage of positive reactive cells was not related to macroscopic or histologic tumor type. Greater fixation rates were observed in this series compared to those previously reported, suggesting greater proliferation rates in these patients.

Adenocarcinoma↗

[Results of curative, distal resection of stomach neoplasms].

Between 1962 and 1971 there were operated 99 patients suffering from gastric cancer. From these, 83% could be controlled as long-term follow-up. The overall survival rate after one year was 68%, after three years 40% and after five years 36%. The patients with tumor-free lymph nodes showed a 5-year survival rate of 49% while of those with tumor-involved lymph nodes only 17% lived longer than five years. The survival rate, especially of older patients (above 60 years), showed with a distal gastric resection compared to a total gastric resection a significant lower postoperative mortality, a better quality of life and a better survival rate. A total gastric resection should only be indicated in cases in which a radical tumor resection could not be realized with a distal gastric resection.

Adenocarcinoma↗