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Results for “STREPTODORNASE AND STREPTOKINASE”

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At least 37 records · Page 2Linked to original sources
PubMed1977

Skin reactivity to Candida and streptokinase-streptodornase antigens in normal pediatric subjects: influence of age and acute illness.

Tests for delayed cutaneous hypersensitivity were carried out with Candida and streptokinase-streptodornase antigens in 245 normal pediatric subjects, ranging in age from 17 days to 5 10/12 years. The group comprised patients with a variety of acute illnesses and a series of control subjects. There was a progressive increase in the frequency of cutaneous responses with age. About one-third of infants under one year and four-fifths of one to five-year-old children had positive induration reactions to at least one antigen. Candida was the more reactive antigen in the first year of life; thereafter there was comparable responsiveness to both antigens. Our results showed no difference in percent reactivity between acutely ill and control subjects.

Acute Disease↗
PubMed1977

Induction of rat homocytotropic antibody against streptokinase-streptodornase (SK-SD) and specific neutralization of the antibody by low molecular weight component of SK-SD.

Homocytotrophic antibodies (HCA) were produced in rats by primary injection of streptokinase-streptodornase (SK-SD) after the antigen was absorbed on alminum hydroxide gel. The properties of rat SK-SD-specific HCA were qualitatively similar to SK-SD skin-sensitizing antibodies found in sera of human beings, namely, homocytotropic activity (48 h homologous PCA reaction), heat lability at 56 degrees C, and inactivation by reduction with 2-mercaptoethanol followed by alkylation with iodoacetamide. In neutralization tests, D-SK-SD, a low molecular hapten-like substance contained in SK-SD preparation, absorbed the antibody against ND-SK-SD antigen-specifically. The neutralizing activity mostly resided in fraction 1 of D-SK-SD separated through DEAE-Sephadex A-25 ion-exchange column, opposing the inhibitory activity of fraction 3 on lymphocyte transformation. The possible implication of these findings in the immunological treatment of streptococcal disorders is discussed.

Animals↗
PubMed1979

Inhibition of polymorphonuclear leukocyte chemotaxis by streptokinase-streptodornase.

Leukotaxis of circulating polymorphonuclear leukocytes (PMN's) appears to be a critical step in the generation of local inflammatory reactions. The present studies demonstrate a reversible, dose-dependent inhibition of PMN chemotaxis by streptokinase-streptodornase (SK-SD). This inhibition does not appear to depend upon the presence of lymphocytes or the release of chemokinetic humoral factors and phagocytic and bactericidal capacities of PMN's are unaffected by the doses of SK-SD employed.

Cell Migration Inhibition↗
PubMed1991

Efficacy of oral streptokinase-streptodornase in the treatment of ankle sprains.

To evaluate the analgesic and antiinflammatory properties of oral streptokinase-streptodornase (SS) in cases of minor trauma, 190 patients with ankle sprains were studied. Subjects were randomly given an active drug or a placebo in doses of two tablets three times a day for eight days. A scoring system was used to rate the following symptoms: spontaneous pain, mobilization pain, wearing pain, articular disability, flaccidity, muscular spasm, edema, and hematoma. Each symptom was categorized as none (0), mild (1), moderate (3), or severe (4). Patients were evaluated at the beginning of the study and on the fourth and eighth days of treatment. At the end of the trial, the decrease in each symptom score was significantly greater in patients receiving SS than in patients receiving a placebo. Analgesic intake during the study was also noticeably lower in the SS group. The incidence of drug-induced side effects (mainly abdominal discomfort) was minimal. Oral SS ameliorates the inflammatory symptoms associated with ankle sprains and therefore may be used as an alternative to nonsteroidal antiinflammatory drugs.

Adolescent↗