PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “SYMPATHINS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

35 records · Page 2Linked to original sources
PubMed1950

[Sympathin].

Explore the source record for details and available documents.

Catecholamines↗
PubMed1959

The antagonism of cocaine to the action of choline 2,6-xylyl ether bromide at sympathetic nerve endings.

Choline 2,6-xylyl ether bromide (TM10) prevents contraction of the nictitating membrane and of the spleen in response to sympathetic nerve stimulation. It was confirmed that this effect was due to prevention of the release of noradrenaline ("sympathin") at the nerve endings. The intravenous injection of cocaine before choline xylyl ether blocked the action of the latter drug. However, when atropine was injected before the cocaine the effects of large doses of choline xylyl ether were not completely blocked. After block had been produced by choline xylyl ether the injection of cocaine partially restored both the secretion at the sympathetic nerve endings and the responses of the organs supplied by the nerves. Phenoxybenzamine did not restore the secretion at the nerve endings after it had been inhibited by choline xylyl ether, indicating that the latter did not cause an increased uptake of sympathin by the receptors.

Animals↗
PubMed1958

The pressor effect of peptone in the rat.

Peptone normally causes a rise of blood pressure in rats. Since the pressor response was not abolished or even diminished by adrenalectomy, it could not have been caused by a release of pressor substances from the adrenal glands. The group of drugs (dibenamine, dihydroergotamine, ergotamine, tolazoline, nicotine and hexamethonium) which antagonize or block the peptone-induced pressor action suggests that the pressor effect may be secondary to a release of sympathin by the stimulation of sympathetic ganglia. Since it was not possible to duplicate the pressor response to peptone by either 48/80 or histamine, the hypothesis that peptone acts by liberating histamine can be ruled out.

Adrenal Glands↗
PubMed1960

A ganglion-stimulating principle present in peptone.

One of us (W. T. B.) has previously described a pressor effect of peptone in the rat. This effect was considered secondary to a release of sympathin by the stimulation of sympathetic ganglia. The present experiments show that peptone causes contraction of guinea-pig ileum and inferior eyelid of the rat which is antagonized by hexamethonium. Atropine inhibits equiactive doses of peptone and acetylcholine on the guinea-pig ileum and eserine potentiates them. Boiling peptone in concentrated hydrochloric acid or N sodium hydroxide destroys its activity; incubation with proteolytic enzymes (trypsin, pepsin, and chymotrypsin) has no effect on its activity. It is concluded that peptone acts upon the intramural ganglia of the guinea-pig ileum and on sympathetic ganglia which supply the inferior eyelid of the rat.

Acetylcholine↗
PubMed1976

Ahlquist and the development of beta-adrenoceptor antagonists.

The power and fecundity of Ahlquist's original concept of alpha- and beta-receptors can now be seen in dramatic contrast to the obfuscation and sterility of the then contemporary theory of two "sympathins". But when his famous paper appeared in 1948, pharmacologists apparently were not ready for the new idea. Receptor theory was perhaps too esoteric (Dale, one of the great pharmacologists of his time, studiously ignored it) and pharamacological taxonomy was virtually non-existent. The relationship of the new idea to Ehrlich's older ones, with consequent utilitarian implications, was overlooked.

Adrenergic beta-Antagonists↗