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PubMed1981

[Association of disseminated intravascular coagulation and cutaneous crystal cholesterol emboli (author's transl)].

The case of a 72-year-old man with cutaneous cholesterol emboli in association with disseminated intravascular coagulation (D.I.C.) is described. Favouring the crystal cholesterol emboli hypothesis are the livedo reticularis and purpura in the lower extremities, palpable pulses, arterioles containing cholesterol clefts. Favouring the hypothesis of D.I.C. are the purpuric lesions on the ears and nose, acral cyanosis and haemorrhagic bullae on the hands, intravascular fibrinous thrombi, hemostatic abnormalities and the efficacy of heparin. Two pathogenic hypotheses are discussed: 1) "spontaneous" crystal cholesterol emboli have started a D.I.C. following the release of thromboplastic substances; 2) a D.I.C. with its secondary fibrinolysis has provoked a dissolution of the thrombosis which covered the atheromatous plaques and started cholesterol crystal emboli.

Aged↗
PubMed1975

[Role of arterial wall in the process of local thrombus formation after endarterectomy].

The authors have studies the capacity of the endarterectomized arterial wall to release tissue factors of hemocoagulation in blood circulation. According to the investigations performed in 11 patients the endarterectomized artery releases into the circulation at least 3 substances showing a procoagulative action: thromboplastic factor, antiheparin substance and fibrinolysis inhibitors. The dynamics of these substances release into the circulation was studied by the authors experimentally on 74 dogs. The greatest disorders in the hemocoagulation potential at the site of endarterectomy were observed on the day of operation. The operated arterial wall would release the thromboplastic factor during 9 days, antiheparin substance during 5 days and fibrinolysis inhibitors up to 4 days following the operation. Arterial fragmentation is accompanied with reduction of the profibrinolysin content of tissue activator in the operated heart region. There was found a relationship between the process of regeneration of the endarterectomized arterial wall and dynamics of the release of tissue factors of hemocoagulation from it.

Animals↗