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At least 37 records · Page 2Linked to original sources
PubMed1975

The one-step approach to thyroid function tests. The diagnostic thyroxine ratio (DTR)/serum thyroxine (T4) level combination.

A one-step approach to thyroid function tests is reported, using Tetralute kits (Ames). Two parameters are obtained simultaneously--namely, the serum thyroxine (T4) level and the diagnostic thyroxine ratio (DTR), which correlates well with the free thyroxine index (FTI) as determined by two separate tests-the T4 level and the triiodothyronine resin uptake ((T3U)) estimations. Data presented from patients with a variety of thyroid states prove that the DTR, particularly in combination with the T4 level, is adequate for the assessment of thyroid dysfunction in almost all circumstances.

Adolescent↗
PubMed1991

Effect of education and feedback on thyroid function testing strategies of primary care clinicians.

We examined the effect of an educational memorandum incorporating simple guidelines for thyroid function testing on test utilization in a primary care health maintenance organization practice. We then compared the effectiveness of a reminder alone or combined with individual test ordering feedback at maintaining an effect. The subjects were 17 physicians and 13 physician assistants and nurse practitioners separated into two similar study groups with little clinical interaction. Both groups responded to the education with increased compliance (from 36% to greater than 67%) with the recommended testing strategy. The group subsequently receiving only a reminder showed a further increase in compliance from 68% to 81% at 6 months and 79% at 12 months. The group receiving a reminder and feedback showed no subsequent change in testing pattern (65% compliance before the reminder-feedback and 64% at both subsequent measurements). The effect of the educational intervention was greater on nurse practitioners and physician assistants than physicians (absolute increase in compliance, 63% vs 28%). We conclude that education can be an effective tool for modifying clinician testing patterns to conform to simple clinical guidelines. Further study of the effect of education and other strategies on compliance with more complex guidelines is needed.

Attitude of Health Personnel↗
PubMed1975

A strategy for thyroid function tests.

The concept of decision-aiding ranges were introduced to improve diagnostic efficiency. The clinical uncertainty in distinguishing borderline cases of hyperthyroidism and hypothyroidism among 1559 consecutive requests for thyroid function tests was 47%. This was reduced to 22% by using the free thyroxine index and to under 2% by using specific tests determined by the decision-aiding ranges.

Bayes Theorem↗
PubMed1992

Thyroid function tests are rarely abnormal in patients with severe hyperemesis gravidarum.

OBJECTIVES: There is considerable controversy in the literature as to the cause of hyperemesis gravidarum. The aim of this project was to measure a range of thyroid hormone levels in a group of hyperemetic pregnant women. PATIENTS: The study was carried out in 10 first trimester pregnant women with hyperemesis gravidarum. All had been admitted to hospital due to the severity of their symptoms. Fifty age matched, healthy first trimester pregnant women were used as controls. MEASUREMENTS: Blood samples from the women were analysed for total T3 (TT3), total T4 (TT4), free T4 (FT4), TSH, thyrotrophin receptor antibodies (TRAb), thyroid stimulating antibodies (TSAb) and thyroid microsomal and thyroglobulin antibodies. Human chorionic gonadotrophin (hCG) levels were also measured. RESULTS: While individual patients were found to have some abnormal thyroid function tests the group as a whole showed no consistent pattern of abnormality and did not differ significantly from a group of healthy first trimester pregnant women. hCG levels were also within the normal range in the hyperemetic patients. DISCUSSION: None of the women in this study received any antithyroid medication and their symptoms improved as the pregnancy progressed. These results would suggest that there is no underlying thyroid abnormality in patients with hyperemesis gravidarum. It would appear that neither thyroid hormones, nor hCG contribute to the pathogenesis of the condition.

Antibodies↗
PubMed1975

[Correlation studies of some thyroid function tests (author's transl)].

The results of a thyroid test based on ion exchange and column chromatographic separation and of two radiochemical T4 and three T3 tests were carried out with commercially available reagent packs ready for use, and were compared with the PBI values found in the same serum sample in each case. This also tested the analytical precision of each method. A good correlation was found between the PBI and the T4 values, while the accuracy of the T3 tests was unsatisfactory.

Autoanalysis↗
PubMed1977

Thyroid function tests during the early phase of subacute thyroiditis.

Six patients with subacute thyroditis were followed with serial measurements of T4, FT4, TSH and RAI uptake. Five of the six underwent TRH stimulation early in the course of their illness. All six patients had elevated or high normal values for T4 and FT4 at the time of their clinical presentation (mean = 13.8 microgram per 100 ml and 3.9 ng per 100 ml, respectively). RAI uptakes were 1% or less in all six. TRH testing revealed a suppressed TSH response (mean deltaTSH less than0.1 muU/ml) in all five patients tested, suggesting hyperthyroidism. After initial studies were performed, five patients were treated with L-triiodothyronine (L-T3) and one with aspirin. All patients improved over a two to four week period of time, no relapses being noted.

Adult↗
PubMed1978

[Value of thyroid function tests after long term hormone therapy].

Estrogens are known to change the level of specific circulating proteinthyroid binding globulin (TBG). In view of this, a study was conducted of the effect of some hormonal oral contraceptives on the thyroid function by using routine procedures: thyroid scintigraphy, protein bound iodine (PBI), determination of thyroid hormones thyroxine and triiodothyronine. No statistically significant difference was found between the experimental (N = 84) and the control (N = 34) group.

Adult↗
PubMed1977

Evaluation of thyroid functions in leprosy. I. Thyroid function tests.

Twenty six patients of different types of leprosy were studied for radio active iodine uptake (I131) and serum levels of triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH). None of the patients had clinical evidence of thyroid involvement. No significant difference was found between the values obtained in patients and normals and in different varieties of leprosy.

Female↗